Human Serum Potentiates the Expression of Genes Associated with Antifungal Drug Resistance in C. albicans Biofilms on Central Venous Catheters

Mycopathologia

Volumn 179, Issue 3-4, 2015, Pages 195-204

  Samaranayake, L P ^a,b   Anil, S ^c   Hashem, M ^b   Vellappally, S ^b   Cheung, B P K ^d  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

C. albicans biofilms; Central venous catheters; Drug resistance genes; Serum

Indexed keywords

CANDIDA; CANDIDA ALBICANS;

ANTIFUNGAL AGENT; FUNGAL PROTEIN;

ADVERSE EFFECTS; ANTIFUNGAL RESISTANCE; BIOFILM; CANDIDA ALBICANS; CENTRAL VENOUS CATHETER; CHEMISTRY; DRUG EFFECTS; FUNGUS HYPHAE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MALE; MEDICAL DEVICE CONTAMINATION; METABOLISM; MICROBIOLOGY; SERUM; UPREGULATION;

ANTIFUNGAL AGENTS; BIOFILMS; CANDIDA ALBICANS; CENTRAL VENOUS CATHETERS; DRUG RESISTANCE, FUNGAL; EQUIPMENT CONTAMINATION; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; HYPHAE; MALE; SERUM; UP-REGULATION;

EID: 84924806491     PISSN: 0301486X     EISSN: 15730832     Source Type: Journal    
DOI: 10.1007/s11046-014-9848-z     Document Type: Article

References (35)

1. Perlroth J, Choi B, Spellberg B. Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol. 2007;45(4):321–46. doi:10.1080/13693780701218689.
2. Kojic EM, Darouiche RO. Candida infections of medical devices. Clin Microbiol Rev. 2004;17(2):255–67.
3. Cauda R. Candidaemia in patients with an inserted medical device. Drugs. 2009;69(Suppl 1):33–8. doi:10.2165/11315520-000000000-00000.
4. Mukherjee PK, Chandra J. Candida biofilm resistance. Drug Res Updates. 2004;7(4–5):301–9. doi:10.1016/j.drup.2004.09.002.
5. Nailis H, Kucharikova S, Ricicova M, Van Dijck P, Deforce D, Nelis H, et al. Real-time PCR expression profiling of genes encoding potential virulence factors in Candida albicans biofilms: identification of model-dependent and -independent gene expression. BMC Microbiol. 2010;10:114. doi:10.1186/1471-2180-10-114.
6. Samaranayake LP, McCourtie J, MacFarlane TW. Factors affecting the in vitro adherence of Candida albicans to acrylic surfaces. Arch Oral Biol. 1980;25(8–9):611–5.
7. Nikawa H, Nishimura H, Makihira S, Hamada T, Sadamori S, Samaranayake LP. Effect of serum concentration on Candida biofilm formation on acrylic surfaces. Mycoses. 2000;43(3–4):139–43.
8. Samaranayake YH, Cheung BP, Yau JY, Yeung SK, Samaranayake LP. Human serum promotes Candida albicans biofilm growth and virulence gene expression on silicone biomaterial. PLoS One. 2013;8(5):e62902. doi:10.1371/journal.pone.0062902.
9. Ramage G. Vande Walle K, Wickes BL, Lopez-Ribot JL. Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms. Antimicrob Agents Chemother. 2001;45(9):2475–9.
10. Baillie GS, Douglas LJ. Matrix polymers of Candida biofilms and their possible role in biofilm resistance to antifungal agents. J antimicrob Chemother. 2000;46(3):397–403.
11. Bachmann SP, Ramage G, VandeWalle K, Patterson TF, Wickes BL, Lopez-Ribot JL. Antifungal combinations against Candida albicans biofilms in vitro. Antimicrob Agents Chemother. 2003;47(11):3657–9.
12. Vediyappan G, Rossignol T, d’Enfert C. Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans. Antimicrob Agents Chemother. 2010;54(5):2096–111. doi:10.1128/AAC.01638-09.
13. Al-Fattani MA, Douglas LJ. Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance. J Med Microbiol. 2006;55(Pt 8):999–1008. doi:10.1099/jmm.0.46569-0.
14. Kuhn DM, Chandra J, Mukherjee PK, Ghannoum MA. Comparison of biofilms formed by Candida albicans and Candida parapsilosis on bioprosthetic surfaces. Infect Immun. 2002;70(2):878–88.
15. Garcia-Sanchez S, Aubert S, Iraqui I, Janbon G, Ghigo JM, d’Enfert C. Candida albicans biofilms: a developmental state associated with specific and stable gene expression patterns. Eukaryot Cell. 2004;3(2):536–45.
16. Marchais V, Kempf M, Licznar P, Lefrancois C, Bouchara JP, Robert R, et al. DNA array analysis of Candida albicans gene expression in response to adherence to polystyrene. FEMS Microbiol Lett. 2005;245(1):25–32. doi:10.1016/j.femsle.2005.02.014.
17. Murillo LA, Newport G, Lan CY, Habelitz S, Dungan J, Agabian NM. Genome-wide transcription profiling of the early phase of biofilm formation by Candida albicans. Eukaryot Cell. 2005;4(9):1562–73. doi:10.1128/EC.4.9.1562-1573.2005.
18. Rogers PD, Barker KS. Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates. Antimicrob Agents Chemother. 2003;47(4):1220–7.
19. Mateus C, Crow SA Jr, Ahearn DG. Adherence of Candida albicans to silicone induces immediate enhanced tolerance to fluconazole. Antimicrob Agents Chemother. 2004;48(9):3358–66. doi:10.1128/AAC.48.9.3358-3366.2004.
20. Lopez-Ribot JL, McAtee RK, Lee LN, Kirkpatrick WR, White TC, Sanglard D, et al. Distinct patterns of gene expression associated with development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. Antimicrob Agents Chemother. 1998;42(11):2932–7.
21. Henry KW, Nickels JT, Edlind TD. Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother. 2000;44(10):2693–700.
22. Thein ZM, Samaranayake YH, Samaranayake LP. Characteristics of dual species Candida biofilms on denture acrylic surfaces. Arch Oral Biol. 2007;52(12):1200–8. doi:10.1016/j.archoralbio.2007.06.007.
23. Jin Y, Yip HK, Samaranayake YH, Yau JY, Samaranayake LP. Biofilm-forming ability of Candida albicans is unlikely to contribute to high levels of oral yeast carriage in cases of human immunodeficiency virus infection. J Clin Microbiol. 2003;41(7):2961–7.
24. Samaranayake YH, Dassanayake RS, Jayatilake JA, Cheung BP, Yau JY, Yeung KW, et al. Phospholipase B enzyme expression is not associated with other virulence attributes in Candida albicans isolates from patients with human immunodeficiency virus infection. J Med Microbiol. 2005;54(Pt 6):583–93. doi:10.1099/jmm.0.45762-0.
25. Samaranayake YH, Dassanayake RS, Cheung BP, Jayatilake JA, Yeung KW, Yau JY, et al. Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium. APMIS. 2006;114(12):857–66. doi:10.1111/j.1600-0463.2006.apm_479.x.
26. Finkel JS, Mitchell AP. Genetic control of Candida albicans biofilm development. Nat Rev Microbiol. 2011;9(2):109–18. doi:10.1038/nrmicro2475.
27. Raad I, Costerton W, Sabharwal U, Sacilowski M, Anaissie E, Bodey GP. Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement. J Infect Dis. 1993;168(2):400–7.
28. Francois P, Vaudaux P, Lew PD. Role of plasma and extracellular matrix proteins in the physiopathology of foreign body infections. Ann Vasc Surg. 1998;12(1):34–40. doi:10.1007/s100169900112.
29. Ding X, Liu Z, Su J, Yan D. Human serum inhibits adhesion and biofilm formation in Candida albicans. BMC Microbiol. 2014;14:80. doi:10.1186/1471-2180-14-80.
30. Jayatilake JA, Samaranayake YH, Cheung LK, Samaranayake LP. Quantitative evaluation of tissue invasion by wild type, hyphal and SAP mutants of Candida albicans, and non-albicans Candida species in reconstituted human oral epithelium. J Oral Pathol Med. 2006;35(8):484–91. doi:10.1111/j.1600-0714.2006.00435.x.
31. Seneviratne CJ, Jin LJ, Samaranayake YH, Samaranayake LP. Cell density and cell aging as factors modulating antifungal resistance of Candida albicans biofilms. Antimicrob Agents Chemother. 2008;52(9):3259–66. doi:10.1128/AAC.00541-08.
32. Khot PD, Suci PA, Miller RL, Nelson RD, Tyler BJ. A small subpopulation of blastospores in candida albicans biofilms exhibit resistance to amphotericin B associated with differential regulation of ergosterol and beta-1,6-glucan pathway genes. Antimicrob Agents Chemother. 2006;50(11):3708–16. doi:10.1128/AAC.00997-06.
33. Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA. Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infect Immun. 2003;71(8):4333–40.
34. Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Chemother. 1995;39(11):2378–86.
35. White TC. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother. 1997;41(7):1482–7.