Loss of N-cadherin is associated with loss of E-cadherin expression and poor outcomes of liver resection in hepatocellular carcinoma

Journal of Surgical Research

Volumn 194, Issue 1, 2015, Pages 167-176

  Liu, Yang An ^a,b   Liang, Bin Yong ^a   Guan, Yan ^a   You, Jian ^a   Zhu, Ling ^b   Chen, Xiao Ping ^a   Huang, Zhi Yong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Wuhan Hospital 12   (China)

Author keywords

E cadherin; Expression; Hepatocellular carcinoma; N cadherin; Survival

Indexed keywords

ALPHA FETOPROTEIN; NERVE CELL ADHESION MOLECULE; UVOMORULIN; CADHERIN; CDH2 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN;

ADULT; AGED; ALPHA FETOPROTEIN BLOOD LEVEL; ARTICLE; CANCER PROGNOSIS; CANCER SIZE; CANCER SURGERY; CELL DIFFERENTIATION; CHILD PUGH SCORE; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DOWN REGULATION; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; METASTASIS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SURVIVAL RATE; TUMOR DIFFERENTIATION; TUMOR INVASION; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; LIVER NEOPLASMS; MIDDLE AGED; MORTALITY;

ADULT; AGED; ANTIGENS, CD; CADHERINS; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATECTOMY; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS;

EID: 84924750547     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2014.09.031     Document Type: Article

References (37)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA Cancer J Clin 61 2011 69
2. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, and D.M. Parkin Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int J Cancer 127 2010 2893
3. R. Adam, P. Bhangui, and E. Vibert Resection or transplantation for early hepatocellular carcinoma in a cirrhotic liver: does size define the best oncological strategy? Ann Surg 256 2012 883
4. N.N. Rahbari, A. Mehrabi, and N.M. Mollberg Hepatocellular carcinoma: current management and perspectives for the future Ann Surg 253 2011 453
5. C.H. Cha, L. Ruo, and Y. Fong Resection of hepatocellular carcinoma in patients otherwise eligible for transplantation Ann Surg 238 2003 315 discussion 321-313
6. Z.Y. Huang, B.Y. Liang, and M. Xiong Long-term outcomes of repeat hepatic resection in patients with recurrent hepatocellular carcinoma and analysis of recurrent types and their prognosis: a single-center experience in China Ann Surg Oncol 19 2012 2515
7. S. Coulon, F. Heindryckx, A. Geerts, C. Van Steenkiste, I. Colle, and H. Van Vlierberghe Angiogenesis in chronic liver disease and its complications Liver Int 31 2011 146
8. I.J. Fidler The pathogenesis of cancer metastasis: the "seed and soil" hypothesis revisited Nat Rev Cancer 3 2003 453
9. B.A. Truong Quang, M. Mani, O. Markova, T. Lecuit, and P.F. Lenne Principles of E-cadherin supramolecular organization in vivo Curr Biol 23 2013 2197
10. J.M. Gooding, K.L. Yap, and M. Ikura The cadherin-catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures Bioessays 26 2004 497
11. E.W. Howard, K.D. Camm, Y.C. Wong, and X.H. Wang E-cadherin upregulation as a therapeutic goal in cancer treatment Mini Rev Med Chem 8 2008 496
12. E. Colas, N. Pedrola, and L. Devis The EMT signaling pathways in endometrial carcinoma Clin Transl Oncol 14 2012 715
13. D. Gao, L.T. Vahdat, S. Wong, J.C. Chang, and V. Mittal Microenvironmental regulation of epithelial-mesenchymal transitions in cancer Cancer Res 72 2012 4883
14. T. Osada, M. Sakamoto, and Y. Ino E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma Hepatology 24 1996 1460
15. G. Li, K. Satyamoorthy, and M. Herlyn N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells Cancer Res 61 2001 3819
16. D. Ciolczyk-Wierzbicka, D. Gil, and P. Laidler The inhibition of cell proliferation using silencing of N-cadherin gene by siRNA process in human melanoma cell lines Curr Med Chem 19 2012 145
17. C. Nagi, M. Guttman, and S. Jaffer N-cadherin expression in breast cancer: correlation with an aggressive histologic variant - invasive micropapillary carcinoma Breast Cancer Res Treat 94 2005 225
18. H. Tanaka, E. Kono, and C.P. Tran Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance Nat Med 16 2010 1414
19. T. Kashima, J. Kawaguchi, and S. Takeshita Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis Am J Pathol 155 1999 1549
20. L.D. Derycke, and M.E. Bracke N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling Int J Dev Biol 48 2004 463
21. E. Darai, J.Y. Scoazec, and F. Walker-Combrouze Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases Hum Pathol 28 1997 922
22. S. Utsuki, Y. Sato, H. Oka, B. Tsuchiya, S. Suzuki, and K. Fujii Relationship between the expression of E-, N-cadherins and beta-catenin and tumor grade in astrocytomas J Neurooncol 57 2002 187
23. S.B. Cho, K.H. Lee, and J.H. Lee Expression of E- and N-cadherin and clinicopathology in hepatocellular carcinoma Pathol Int 58 2008 635
24. D.D. Seo, H.C. Lee, and H.J. Kim Neural cadherin overexpression is a predictive marker for early postoperative recurrence in hepatocellular carcinoma patients J Gastroenterol Hepatol 23 2008 1112
25. D.Q. Zhan, S. Wei, and C. Liu Reduced N-cadherin expression is associated with metastatic potential and poor surgical outcomes of hepatocellular carcinoma J Gastroenterol Hepatol 27 2012 173
26. M. Garziera, V. Canzonieri, and R. Cannizzaro Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer PLoS One 8 2013 e77035
27. S.P. Ivy, J.Y. Wick, and B.M. Kaufman An overview of small-molecule inhibitors of VEGFR signaling Nat Rev Clin Oncol 6 2009 569
28. M. Moghbeli, O. Moaven, and B. Memar Role of hMLH1 and E-cadherin promoter methylation in gastric cancer progression J Gastrointest Cancer 45 2013 40
29. C. Guillot, and T. Lecuit Mechanics of epithelial tissue homeostasis and morphogenesis Science 340 2013 1185
30. S. Yamashita, Y. Tsujino, K. Moriguchi, M. Tatematsu, and T. Ushijima Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray Cancer Sci 97 2006 64
31. P. Kober, M. Bujko, J. Oledzki, A. Tysarowski, and J.A. Siedlecki Methyl-CpG binding column-based identification of nine genes hypermethylated in colorectal cancer Mol Carcinog 50 2011 846
32. M.M. de Yzaguirre, J.S. Hernandez, and P.F. Navarro Epigenetic silencing of E- and N-cadherins in the stroma of mouse thymic lymphomas Carcinogenesis 27 2006 1081
33. K. Araki, T. Shimura, and H. Suzuki E/N-cadherin switch mediates cancer progression via TGF-beta-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma Br J Cancer 105 2011 1885
34. V. Sigurdsson, B. Hilmarsdottir, and H. Sigmundsdottir Endothelial induced EMT in breast epithelial cells with stem cell properties PLoS One 6 2011 e23833
35. N.P. Gunasinghe, A. Wells, E.W. Thompson, and H.J. Hugo Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer Cancer Metastasis Rev 31 2012 469
36. B. Tsuchiya, Y. Sato, T. Kameya, I. Okayasu, and K. Mukai Differential expression of N-cadherin and E-cadherin in normal human tissues Arch Histol Cytol 69 2006 135
37. B.K. Straub, S. Rickelt, and R. Zimbelmann E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells J Cell Biol 195 2011 873