Dementia: Type 2 diabetes has a slow and insidious effect on cognition

Nature Reviews Neurology

Volumn 11, Issue 3, 2015, Pages 127-128

  Umegaki, Hiroyuki ^a  

^a Department of Community Healthcare and Geriatrics ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ALZHEIMER DISEASE; COGNITIVE DEFECT; COMORBIDITY; DENERVATION; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; EXECUTIVE FUNCTION; GLYCEMIC CONTROL; HUMAN; INSULIN RESISTANCE; MENTAL DETERIORATION; MULTIINFARCT DEMENTIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PARKINSON DISEASE; PRIORITY JOURNAL; QUALITY OF LIFE; SHORT SURVEY; COMPLICATION; FEMALE; MALE;

COGNITION DISORDERS; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE;

EID: 84924693994     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol201517     Document Type: Short Survey

References (10)

1. Bohnen, N. I., et al. Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease. Parkinsonism Relat. Disord. 20, 1394-1398 (2014
2. Rawlings, A. M., et al. Diabetes in midlife and cognitive change over 20 years: a cohort study. Ann. Intern. Med. 161, 785-793 (2014
3. Cukierman, T., Gerstein, H. C. & Williamson, J. D. Cognitive decline and dementia in diabetes-systematic overview of prospective observational studies. Diabetologia 48, 2460-2469 (2005
4. Schrijvers, E. M., et al. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study. Neurology 75, 1982-1987 (2010
5. Schubert, M., et al. Insulin receptor substrate 2 deficiency impairs brain growth and promotes tau phosphorylation. J. Neurosci. 23, 7084-7092 (2013
6. Matsuzaki, T., et al. Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study. Neurology 75, 764-770 (2010
7. Thambisetty, M., et al. Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging. JAMA Neurol. 70, 1167-1172 (2013
8. Umegaki, H. Impaired glycemia and Alzheimer's disease. Neurobiol. Aging 35, e21 (2014
9. Launer, L. J., et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol. 10, 969-977 (2011
10. Luchsinger, J. A., et al. Improved diabetes control in the elderly delays global cognitive decline. Nutr. Health Aging 15, 445-449 (2011