Increased oxidative stress and mitochondrial dysfunction in zucker diabetic rat liver and brain

Cellular Physiology and Biochemistry

Volumn 35, Issue 3, 2015, Pages 1241-1251

  Raza, Haider ^a   John, Annie ^a   Howarth, Frank Christopher ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Brain; Liver; Mitochondrial dysfunction; Oxidative stress; Zucker diabetic rats

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME P450 2E1; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; I KAPPA B; NF-KAPPAB INHIBITOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GLUTATHIONE METABOLISM; HUMAN; INSULIN RESISTANCE; LIPID PEROXIDATION; METABOLIC STRESS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PEROXIDATION; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN SYNTHESIS; RAT; RESPIRATORY FUNCTION; TISSUE PREPARATION; ZUCKER DIABETIC FATTY RAT; ANIMAL; BIOSYNTHESIS; BRAIN; EXPERIMENTAL DIABETES MELLITUS; GENETICS; LIVER; METABOLISM; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXIDATION REDUCTION REACTION; PATHOLOGY; ZUCKER RAT;

RATTUS;

ANIMALS; BRAIN; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; I-KAPPA B PROTEINS; INSULIN RESISTANCE; LIVER; MITOCHONDRIA; NITRIC OXIDE; OBESITY; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, ZUCKER; REACTIVE OXYGEN SPECIES;

EID: 84924692059     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373947     Document Type: Article

References (36)

1. Clark JB, Palmer CJ, Shaw WN: The diabetic Zucker fatty rat. Proc Soc Exp Biol Med 1983;173 68-75.
2. Gustavsson C, Soga T, Wahlstrom E, Vesterlund M, Azimi A, Norstedt G, Tollet-Egnell P: Sex-dependent hepatic transcript and metabolites in the development of glucose intolerance and insulin resistance in Zucker diabetic fatty rats. J Mol Endocrinol 2011;47:129-143.
3. Chander PN, Gealeman O, Brodsky SV, Elitok S, Tojo A, Crabtree M, Gross SS, Goligorsky MS: Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen. J Am Soc Nephrol 2004;15:2391-2403.
4. Boudina S, Abel ED: Diabetic cardiomyopathy revisited. Circulation 2007;115:3213-3223.
5. Giacco F, Brownlee M: Oxidative stress and diabetic complications. Circ Res 2010;107:1058-1070.
6. Sánchez D, Quiñones M, Moulay L, Muguerza B, Miguel M, Aleixandre A: Soluble fiber-enriched diets improve inflammation and oxidative stress biomarkers in Zucker fatty rats. Pharmacol Res 2011;64:31-35.
7. Chentouf M, Dubois G, Jahannaut C, Castex F, Lajoix AD, Gross R, Peraldi-Roux S: Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets. PLoS ONE 2011;6:e22954.
8. Howarth FC, Qureshi MA, Hassan Z, Al Kury LT, Isaev D, Parekh K, Yammahi SR, Oz M, Adrian TE, Adeghate E: Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca+2 signalling in young type 2 Zucker diabetic fatty rat heart. Exp Physiol 2011;96:325-337.
9. Howarth FC, Qureshi MA, Hassan Z, Isaev D, Parekh K, John A, Oz M, Raza H, Adeghate E, Adrian TE: Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in elderly type 2 Zucker diabetic fatty rat heart. Mol Cell Biochem 2012;361:267-280.
10. Daniels A, Linz D, van Bilsen M, Rutten H, Sadowski T, Ruf S, Juretschke HP, Neumann-Haefelin C, Munts C, van der Vusse GJ, van Nieuwenhoven FA: Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats. Eur J Heart Fail 2012;14:193-201.
11. Wang CH, Wang CC, Huang HC, Wei YH: Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes. FEBS J 2013;280:1039-1050.
12. Liu H-Y, Yehuda-shnaidman E, Hong T, Han J, Pi J, Liu Z: Prolonged exposure to insulin suppresses mitochondrial production in primary hepatocytes. J Biol Chem 2009;284:14087-14095.
13. Raza H, John A, Howarth FC: Alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly Zucker diabetic fatty rat heart. Int J Mol Sci 2012;13:16241-16254.
14. Raza H, John A, Howarth FC: Increased metabolic stress in Zucker diabetic fatty rat kidney and pancreas. Cell Physiol Biochem 2013;32:1610-1620.
15. Raza H, Prabu SK, John A, Avadhani NG: Impaired mitochondrial respiratory functions and oxidative stress in streptozotocin-induced diabetic rats. Int J Mol Sci 2011;12:3133-3147.
16. Beers RF, Sizer IW: A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1952;195:133-140.
17. Raza H, Prabu SK, Robin M-A, Avadhani NG: Elevated mitochondrial cytochrome P4502E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue specific variations and roles in oxidative stress. Diabetes 2004;53:185-194.
18. Raza H, John A, Nemmar A: Short-term effects of nose-only cigarette smoke exposure on glutathione redox homeostasis, cytochrome P450 1A1/2 and respiratory enzyme activities in mice tissues. Cell Physiol Biochem 2013;31:683-692.
19. Birch-Machin MA, Turnbull DM: Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues. Methods Cell Biol 2001;65:97-117.
20. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685.
21. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4354.
22. Shimabukuro M, Zhou YT, Levi M, Unger RH: Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 1998;95:2498-2502.
23. Giacco F, Brownlee M: Oxidative stress and diabetic complications. Circ Res 2010;107:1058-1070.
24. Tianzheng Y, James LR, Yisang Y: Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci USA 2006;103:2653-2658.
25. Tokuyama Y, Sturis J, DePaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI: Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 1995;44:1447-1457.
26. Shen GX: Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidase. Can J Physiol Pharmacol 2010;88:241-248.
27. Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE: Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci USA 2009;106:17787-17792.
28. McClung JP, Roneker CA, Mu W, Lisk DJ, Langlais P, Liu F, Lei XG: Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc Natl Acad Sci USA 2004;101:8852-8857.
29. Tsai KH, Wang WJ, Lin CW, Pai P, Lai TY, Tsai CY, Kuo WW: NADPH oxidase-derived superoxide anion-induced apoptosis is mediated via the JNK-dependent activation of NF-κB in cardiomyocytes exposed to high glucose. J Cell Physiol 2012;227:1347-1357.
30. Mattson MP: Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders. Exp Gerontol 2009;44:625-633.
31. Singh SP, Niemczyk M, Saini D, Awasthi YC, Zimniak L, Zimniak P: Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice. Biochemistry 2008;47:3900-3911.
32. Lakshmanan AP, Harima M, Sukumaran V, Soetikno V, Thandavarayan RA, Suzuki K, Kodama M, Nagata M, Takagi R, Watanabe K: Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Biochem Pharmacol 2012;83:653-660.
33. Syed I, Kyathanahalli CN, Jayaram B, Govind S, Rhodes CJ, Kowluru RA, Kowluru A: Increased phagocytelike NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes 2011;60:2843-2852.
34. Muller FL, Liu Y, Remmen HV: Complex III releases superoxide to both side of the inner mitochondrial membrane. J Biol Chem 2004;279:49064-49073.
35. Hoffman DL, Brookes PS: Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. J Biol Chem 2009;284:16236-16245.
36. Al-Otaiba A, John A, Al-Belooshi T, Raza H: Redox homeostasis and respiratory metabolism in camels (Camelus dromedaries): comparisons with domestic goats and laboratory rats and mice. J Comp Phsiol B 2010;180:1121-1132.