Chronic hypertension in pregnancy and the risk of congenital malformations: A cohort study

American Journal of Obstetrics and Gynecology

Volumn 212, Issue 3, 2015, Pages 337.e1-337.e14

  Bateman, Brian T ^a,b   Huybrechts, Krista F ^a   Fischer, Michael A ^a   Seely, Ellen W ^a   Ecker, Jeffrey L ^b   Oberg, Anna S ^c   Franklin, Jessica M ^a   Mogun, Helen ^a   Hernandez Diaz, Sonia ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

birth defect; drug; epidemiology; hypertension; pregnancy

Indexed keywords

ANTIHYPERTENSIVE AGENT; INSULIN; ORAL ANTIDIABETIC AGENT;

ADULT; AFRICAN AMERICAN; AGE; ANTIHYPERTENSIVE THERAPY; ARTICLE; CLEFT LIP; CLEFT PALATE; COHORT ANALYSIS; CONGENITAL MALFORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GASTROINTESTINAL MALFORMATION; HEALTH CARE UTILIZATION; HEART ATRIUM SEPTUM DEFECT; HEART LEFT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART RIGHT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART SINGLE VENTRICLE; HEART VENTRICLE SEPTUM DEFECT; HUMAN; KIDNEY DISEASE; LUNG MALFORMATION; MAJOR CLINICAL STUDY; MATERNAL HYPERTENSION; MEDICAL RECORD REVIEW; PREECLAMPSIA; PREGNANCY DIABETES MELLITUS; PREMATURE LABOR; PRIORITY JOURNAL; PROGENY; PROPENSITY SCORE; RISK FACTOR; UROGENITAL TRACT MALFORMATION; YOUNG ADULT; ADOLESCENT; CHRONIC DISEASE; CONGENITAL ABNORMALITIES; HEART DEFECTS, CONGENITAL; HYPERTENSION; NEWBORN; ODDS RATIO; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; STATISTICAL MODEL;

ADOLESCENT; ADULT; ANTIHYPERTENSIVE AGENTS; CHRONIC DISEASE; COHORT STUDIES; CONGENITAL ABNORMALITIES; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; HYPERTENSION; INFANT, NEWBORN; LOGISTIC MODELS; ODDS RATIO; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PROPENSITY SCORE; RISK FACTORS; YOUNG ADULT;

EID: 84924678248     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2014.09.031     Document Type: Article

References (29)

1. E.V. Kuklina, C. Ayala, and W.M. Callaghan Hypertensive disorders and severe obstetric morbidity in the United States Obstet Gynecol 113 2009 1299 1306
2. B.T. Bateman, P. Bansil, S. Hernandez-Diaz, J.M. Mhyre, W.M. Callaghan, and E.V. Kuklina Prevalence, trends, and outcomes of chronic hypertension: a nationwide sample of delivery admissions Am J Obstet Gynecol 206 2012 134.e1 134.e8
3. S.E. Andrade, M.A. Raebel, and J. Brown Outpatient use of cardiovascular drugs during pregnancy Pharmacoepidemiol Drug Saf 17 2008 240 247
4. B.T. Bateman, S. Hernandez-Diaz, K.F. Huybrechts, K. Palmsten, H. Mogun, J.L. Ecker, and M.A. Fischer Patterns of outpatient antihypertensive medication use during pregnancy in a medicaid population Hypertension 60 2012 913 920
5. R.H. Xie, Y. Guo, and D. Krewski Trends in using beta-blockers and methyldopa for hypertensive disorders during pregnancy in a canadian population Eur J Obstet Gynecol Reprod Biol 171 2013 281 285
6. A.R. Caton, E.M. Bell, and C.M. Druschel Antihypertensive medication use during pregnancy and the risk of cardiovascular malformations Hypertension 54 2009 63 70
7. M.Y. Yakoob, B.T. Bateman, and E. Ho The risk of congenital malformations associated with exposure to beta-blockers early in pregnancy: a meta-analysis Hypertension 62 2013 375 381
8. R. Lennestal, P. Otterblad Olausson, and B. Kallen Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants Eur J Clin Pharmacol 65 2009 615 625
9. E.H. Puho, M. Szunyogh, J. Metneki, and A.E. Czeizel Drug treatment during pregnancy and isolated orofacial clefts in hungary Cleft Palate Craniofac J 44 2007 194 202
10. B.A. Kallen, and P. Otterblad Olausson Maternal drug use in early pregnancy and infant cardiovascular defect Reprod Toxicol 17 2003 255 261
11. W. Cooper, S. Hernandez-Diaz, and P. Arbogast Major congenital malformations after first-trimester exposure to ace inhibitors N Engl J Med 354 2006 2443 2451
12. D.K. Li, C. Yang, S. Andrade, V. Tavares, and J.R. Ferber Maternal exposure to angiotensin converting enzyme inhibitors in the first trimester and risk of malformations in offspring: a retrospective cohort study BMJ 343 2011 d5931
13. A.A. Mitchell Fetal risk from ace inhibitors in the first trimester BMJ 343 2011 d6667
14. K. Palmsten, K.F. Huybrechts, and H. Mogun Harnessing the medicaid analytic extract (max) to evaluate medications in pregnancy: design considerations PLoS One 8 2013 e67405
15. A.V. Margulis, S. Setoguchi, M.A. Mittleman, R.J. Glynn, C.R. Dormuth, and S. Hernandez-Diaz Algorithms to estimate the beginning of pregnancy in administrative databases Pharmacoepidemiol Drug Saf 22 2013 16 24
16. K. Palmsten, K.F. Huybrechts, M.K. Kowal, H. Mogun, and S. Hernández-Díaz Validity of maternal and infant outcomes within nationwide medicaid data Pharmacoepidemiol Drug Saf 23 2014 646 655
17. I.F. Casson, C.A. Clarke, and C.V. Howard Outcomes of pregnancy in insulin dependent diabetic women: results of a five year population cohort study BMJ 315 1997 275 278
18. V.M. Allen, B.A. Armson, and R.D. Wilson Teratogenicity associated with pre-existing and gestational diabetes J Obstet Gynaecol Can 29 2007 927 944
19. S. Hernandez-Diaz, E.F. Schisterman, and M.A. Hernan The birth weight "paradox" uncovered? Am J Epidemiol 164 2006 1115 1120
20. S. Schneeweiss Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics Pharmacoepidemiol Drug Saf 15 2006 291 303
21. E. Rey, and A. Couturier The prognosis of pregnancy in women with chronic hypertension Am J Obstet Gynecol 171 1994 410 416
22. B.M. Sibai, M. Lindheimer, and J. Hauth Risk factors for preeclampsia, abruptio placentae, and adverse neonatal outcomes among women with chronic hypertension. National institute of child health and human development network of maternal-fetal medicine units N Engl J Med 339 1998 667 671
23. V.M. Allen, K. Joseph, K.E. Murphy, L.A. Magee, and A. Ohlsson The effect of hypertensive disorders in pregnancy on small for gestational age and stillbirth: a population based study BMC Pregnancy Childbirth 4 2004 17
24. B.M. Sibai Chronic hypertension in pregnancy Obstet Gynecol 100 2002 369 377
25. B.T. Bateman, and L.L. Simpson Higher rate of stillbirth at the extremes of reproductive age: a large nationwide sample of deliveries in the united states Am J Obstet Gynecol 194 2006 840 845
26. E.B. Clark Pathogenetic mechanisms of congenital cardiovascular malformations revisited Semin Perinatol 20 1996 465 472
27. J. Rychik, N. Ayres, and B. Cuneo American Society of Echocardiography guidelines and standards for performance of the fetal echocardiogram J Am Soc Echocardiogr 17 2004 803 810
28. S. Schneeweiss, and J. Avorn A review of uses of health care utilization databases for epidemiologic research on therapeutics J Clin Epidemiol 58 2005 323 337
29. E. Abalos, L. Duley, D.W. Steyn, and D.J. Henderson-Smart Antihypertensive drug therapy for mild to moderate hypertension during pregnancy Cochrane Database Syst Rev 2007 CD002252