Representative input load of antibiotics to WWTPs: Predictive accuracy and determination of a required sampling quantity

Water Research

Volumn 76, Issue , 2015, Pages 19-32

  Marx, Conrad ^a   Mühlbauer, Viktoria ^b   Schubert, Sara ^b   Oertel, Reinhard ^b   Ahnert, Markus ^a   Krebs, Peter ^a   Kuehn, Volker ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Antibiotics; Prescription data; Recovery rate; Sample quantity; Wastewater treatment plant

Indexed keywords

RECLAMATION; SEWAGE PUMPING PLANTS; WASTEWATER TREATMENT; WATER TREATMENT PLANTS;

ANALYTICAL DATA; HIGH RESOLUTION; INPUT DATAS; PREDICTIVE ACCURACY; PRESCRIPTION DATA; RECOVERY RATE; SAMPLE QUANTITY; SAMPLING CAMPAIGNS; UNCERTAINTY; WASTE WATER TREATMENT PLANTS;

ANTIBIOTICS;

ANTIBIOTIC AGENT; BETA LACTAM; CEFUROXIME; CIPROFLOXACIN; COTRIMOXAZOLE; LEVOFLOXACIN; MACROLIDE; ANTIINFECTIVE AGENT; DRUG; WASTE WATER; WATER POLLUTANT;

ACCURACY ASSESSMENT; ANTIBIOTICS; DATA SET; POLLUTANT; SAMPLING; UNCERTAINTY ANALYSIS; WASTEWATER; WATER TREATMENT;

ACCURACY; ANALYTIC METHOD; ARTICLE; ENVIRONMENT; MONITOR; PRIORITY JOURNAL; PROGNOSIS; SEASONAL VARIATION; SEWER; WASTE WATER MANAGEMENT; WATER POLLUTANT; WATER SAMPLING; ANALYSIS; ENVIRONMENTAL MONITORING; PROCEDURES; SAMPLE SIZE; SEASON; SEWAGE; WASTE WATER; WATER MANAGEMENT;

ANTI-BACTERIAL AGENTS; ENVIRONMENTAL MONITORING; PHARMACEUTICAL PREPARATIONS; SAMPLE SIZE; SEASONS; WASTE DISPOSAL, FLUID; WASTE WATER; WATER POLLUTANTS, CHEMICAL; WATER PURIFICATION;

EID: 84924664046     PISSN: 00431354     EISSN: 18792448     Source Type: Journal    
DOI: 10.1016/j.watres.2015.02.049     Document Type: Article

References (40)

1. Abbott KLACID 250mg-Filmtabletten, Rote Liste Service GmbH - Fachinfo Service 2006, (Summary of medicinal product characteristics).
2. Aktories K., Förstermann U., Hofmann F.B., Starke K. Allgemeine und Spezielle Pharmakologie und Toxikologie 2009, Urban & Fischer Verlag/Elsevier GmbH.
3. Bendz D., Paxeus N.A., Ginn T.R., Loge F.J. Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Hoje River in Sweden. J. Hazard. Mater. 2005, 122(3):195-204.
4. Castiglioni S., Bagnati R., Fanelli R., Pomati F., Calamari D., Zuccato E. Removal of pharmaceuticals in sewage treatment plants in Italy. Environ. Sci. Technol. 2006, 40(1):357-363.
5. Choi K., Kim Y., Park J., Park C.K., Kim M., Kim H.S., Kim P. Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea. Sci. Total Environ. 2008, 405(1-3):120-128.
6. Coutu S., Wyrsch V., Wynn H.K., Rossi L., Barry D.A. Temporal dynamics of antibiotics in wastewater treatment plant influent. Sci. Total Environ. 2013, 458:20-26.
7. Filippini M., Masiero G., Moschetti K. Socioeconomic determinants of regional differences in outpatient antibiotic consumption: evidence from Switzerland. Health Policy 2006, 78(1):77-92.
8. Fresenius Cefotaxim Fresenius 0.5g, Rote Liste Service GmbH - Fachinfo Service 2012, (Summary of medicinal product characteristics).
9. Fresenius Piperacillin Fresenius 1g/2g/4g Rote Liste Service GmbH - Fachinfo Service 2012, (Summary of medicinal product characteristics).
10. Gao P., Ding Y., Li H., Xagoraraki I. Occurrence of pharmaceuticals in a municipal wastewater treatment plant: mass balance and removal processes. Chemosphere 2012, 88(1):17-24.
11. Ghosh G.C., Okuda T., Yamashita N., Tanaka H. Occurrence and elimination of antibiotics at four sewage treatment plants in Japan and their effects on bacterial ammonia oxidation. Water Sci. Technol. 2009, 59(4):779-786.
12. Gobel A., Thomsen A., McArdell C.S., Joss A., Giger W. Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment. Environ. Sci. Technol. 2005, 39(11):3981-3989.
13. Grosso G., Marventano S., Ferranti R., Mistretta A. Pattern of antibiotic use in the community: non-adherence and self-prescription rates in an Italian urban population. Mol. Med. Reports 2012, 5(5):1305-1310.
14. Hirsch R., Ternes T., Haberer K., Kratz K.L. Occurrence of antibiotics in the aquatic environment. Science of the Total Environment 1999, 225(1-2):109-118.
15. HSDB Hazardous Substances Data Bank (HSDB) - Comprehensive, peer-reviewed toxicology data for about 5,000 chemicals 2014.
16. Karthikeyan K.G., Meyer M.T. Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA. Sci. Total Environ. 2006, 361(1-3):196-207.
17. Kümmerer K., Al-Ahmad A., Mersch-Sundermann V. Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test. Chemosphere 2000, 40(7):701-710.
18. Li B., Zhang T. Mass flows and removal of antibiotics in two municipal wastewater treatment plants. Chemosphere 2011, 83(9):1284-1289.
19. Li W., Shi Y., Gao L., Liu J., Cai Y. Occurrence and removal of antibiotics in a municipal wastewater reclamation plant in Beijing, China. Chemosphere 2013, 92(4):435-444.
20. Lindberg R.H., Wennberg P., Johansson M.I., Tysklind M., Andersson B.A.V. Screening of human antibiotic substances and determination of weekly mass flows in five sewage treatment plants in Sweden. Environ. Sci. Technol. 2005, 39(10):3421-3429.
21. Loganathan B., Phillips M., Mowery H., Jones-Lepp T.L. Contamination profiles and mass loadings of macrolide antibiotics and illicit drugs from a small urban wastewater treatment plant. Chemosphere 2009, 75(1):70-77.
22. Martindale W. The Extra Pharmacopoeia 1993, The Pharmaceutical Press, London.
23. McArdell C.S., Molnar E., Suter M.J.F., Giger W. Occurrence and fate of macrolide antibiotics in wastewater treatment plants and in the Glatt Valley Watershed, Switzerland. Environ. Sci. Technol. 2003, 37(24):5479-5486.
24. ODDB Pharmacology of cefuroxime, p. pharmacology of cefuroxime, ywesee, Switzerland 2014.
25. Pharma Doxycyclin AbZ 100 mg/200 mg Tabletten, Rote Liste Service GmbH - Fachinfo Service 2008, (Summary of medicinal product characteristics).
26. Pharma Ciprofloxacin AbZ 100/250/500 mg Filmtabletten, Rote Liste Service GmbH - Fachinfo Service 2012, (Summary of medicinal product characteristics).
27. ® 450mg Filmtabletten, Rote Liste Service GmbH - Fachinfo Service 2012, (Summary of medicinal product characteristics), Berlin.
28. Pharma Penicillin V AbZ 1 Mega Filmtabletten, Rote Liste Service GmbH - Fachinfo Service 2012, (Summary of medicinal product characteristics).
29. Pamreddy A., Hidalgo M., Havel J., Salvado V. Determination of antibiotics (tetracyclines and sulfonamides) in biosolids by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2013, 1298:68-75.
30. Plosz B.G., Leknes H., Liltved H., Thomas K.V. Diurnal variations in the occurrence and the fate of hormones and antibiotics in activated sludge wastewater treatment in Oslo, Norway. Sci. Total Environ. 2010, 408(8):1915-1924.
31. Rossmann J., Schubert S., Gurke R., Oertel R., Kirch W. Simultaneous determination of most prescribed antibiotics in multiple wastewater by SPE-LC-MS/MS. J. Chromatogr. B 2014, 969:162-170. accepted.
32. ® 250mg/500mg Filmtabletten Rote Liste Service GmbH - Fachinfo Service 2009, (Summary of medicinal product characteristics), Berlin.
33. ® 300mg, Rote Liste Service GmbH - Fachinfo Service 2009, (Summary of medicinal product characteristics).
34. Still W., Brodt H.-R., Groll A.H., Just-Nüblin G. Antibiotika-Therapie: Klinik und Praxis der antiinfektiösen Behandlung 2006, Schattauer GmbH, Stuttgart.
35. Straub J.O. An environmental risk assessment for human-use trimethoprim in European surface waters. Antibiotics 2013, 2(1):115-162.
36. Tambosi J.L., de Sena R.F., Favier M., Gebhardt W., Jose H.J., Schroeder H.F., Peralta Muniz Moreira R.d.F. Removal of pharmaceutical compounds in membrane bioreactors (MBR) applying submerged membranes. Desalination 2010, 261(1-2):148-156.
37. Wagenlehner F.M.E., Kinzig-Schippers M., Tischmeyer U., Wagenlehner C., Sorgel F., Dalhoff A., Naber K.G. Pharmacokinetics of ciprofloxacin XR (1000mg) versus levofloxacin (500mg) in plasma and urine of male and female healthy volunteers receiving a single oral dose. International Journal of Antimicrobial Agents 2006, 27(1):7-14.
38. Watkinson A.J., Murby E.J., Costanzo S.D. Removal of antibiotics in conventional and advanced wastewater treatment: Implications for environmental discharge and wastewater recycling. Water Res. 2007, 41(18):4164-4176.
39. Watkinson A.J., Murby E.J., Kolpin D.W., Costanzo S.D. The occurrence of antibiotics in an urban watershed: from wastewater to drinking water. Sci. Total Environ. 2009, 407(8):2711-2723.
40. Zhou L.-J., Ying G.-G., Liu S., Zhao J.-L., Yang B., Chen Z.-F., Lai H.-J. Occurrence and fate of eleven classes of antibiotics in two typical wastewater treatment plants in South China. Sci. Total Environ. 2013, 452:365-376.