Induction of haemeoxygenase-1 improves FFA-induced endothelial dysfunction in rat aorta

Cellular Physiology and Biochemistry

Volumn 35, Issue 3, 2015, Pages 1230-1240

  Han, Fang ^a   Hui, Zongguang ^a   Zhang, Shuxian ^a   Hou, Ningning ^a   Wang, Yali ^a   Sun, Xiaodong ^a  

^a WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Endothelial dysfunction; Free fatty acids; Haemeoxygenase 1

Indexed keywords

ADENOSINE PHOSPHATE; ADIPONECTIN; C REACTIVE PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTOPORPHYRIN; PROTOPORPHYRIN COBALT; SUPEROXIDE; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METALLOPORPHYRIN; NOS3 PROTEIN, RAT; PROTOPORPHYRIN TIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLORIMETRY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INDUCTION; FATTY ACID BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; THORACIC AORTA; VASODILATATION; WESTERN BLOTTING; ANIMAL; AORTA; BIOSYNTHESIS; BLOOD; DRUG EFFECTS; ENDOTHELIUM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY;

RATTUS;

ADIPONECTIN; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AORTA; C-REACTIVE PROTEIN; ENDOTHELIUM; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HUMANS; METALLOPORPHYRINS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OBESITY; OXIDATIVE STRESS; PROTOPORPHYRINS; RATS; SUPEROXIDES; VASODILATION;

EID: 84924662555     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373946     Document Type: Article

References (37)

1. Hurt RT, Frazier TH, McClave SA, Kaplan LM: Obesity epidemic: overview, pathophysiology, and the intensive care unit conundrum. JPEN J Parenter Enteral Nutr 2011;35:4S-13S.
2. Rokholm B, Baker JL, Sorensen TI: The levelling off of the obesity epidemic since the year 1999-a review of evidence and perspectives. Obes Rev 2010;11:835-846.
3. Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH: Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006;113:898-918.
4. Chinen I, Shimabukuro M, Yamakawa K, Higa N, Matsuzaki T, Noguchi K, Ueda S, Sakanashi M, Takasu N: Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats. Endocrinology 2007;148:160-165.
5. Hosick PA, Stec DE: Heme oxygenase, a novel target for the treatment of hypertension and obesity. Am J Physiol Regul Integr Comp Physiol 2012;302:R207-214.
6. Duann P: GEC-targeted HO-1 expression reduces proteinuria in glomerular immune injury. Am J Physiol-Renal Physiol 2009;297:F629.
7. Li M, Kim DH, Tsenovoy PL, Peterson SJ, Rezzani R, Rodella LF, Aronow WS, Ikehara S, Abraham NG: Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes 2008;57:1526-1535.
8. Kim DH, Burgess AP, Li M, Tsenovoy PL, Addabbo F, McClung JA, Puri N, Abraham NG: Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells. J Pharmacol Exp Ther 2008;325:833-840.
9. Li M: Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes 2008;57:15261535.
10. Kim DH: Epoxyeicosatrienoic Acid Agonist Regulates Human Mesenchymal Stem Cell-Derived Adipocytes Through Activation of HO-1-pAKT Signaling and a Decrease in PPARγ. Stem Cells Dev 2010;19:18631873.
11. Cao J: High fat diet enhances cardiac abnormalities in SHR rats: Protective role of heme oxygenase-adiponectin axis. Diabetol Metab Syndr 2011;3:3737.
12. Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K, Fu Y, Motone M, Yamamoto K, Matsuo A, Ohashi K, Kihara S, Funahashi T, Rakugi H, Matsuzawa Y, Ogihara T: Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 2004;43:1318-1323.
13. Wang B, Yu Y, Han L: Adiponectin improves endothelial dysfunction caused by elevated FFAs levels, partially through cAMP-dependent pathway. Diabetes Res Clin Pract 2012;97:119-124.
14. Cao J, Inoue K, Sodhi K, Puri N, Peterson SJ, Rezzani R, Abraham NG: High-fat diet exacerbates renal dysfunction in SHR: reversal by induction of HO-1-adiponectin axis. Obesity (Silver Spring) 2012;20:945-953.
15. Cheng CF, Lian WS, Chen SH, Lai PF, Li HF, Lan YF, Cheng WT, Lin H: Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPARalpha-heme oxygenase-1 signaling pathway. J Cell Physiol 2012;227:239-249.
16. Nuutila P: Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo. J Clin Invest 1992;89:1767.
17. Yu YR, Li HL, Zhang XX: [Effects of free fatty acids on nitric oxide synthase activity and mRNA expression in endothelial cell of SD rat aorta]. Sichuan Da Xue Xue Bao Yi Xue Ban 2008;39:193-196.
18. Arregui B, Lopez B, Garcia SM, Valero F, Navarro C, Fenoy FJ: Acute renal hemodynamic effects of dimanganese decacarbonyl and cobalt protoporphyrin. Kidney Int 2004;65:564-574.
19. Hou N, Han F, Wang M, Huang N, Zhao J, Liu X, Sun X: Perirenal fat associated with microalbuminuria in obese rats. Int Urol Nephrol 2014;46:839-845.
20. Lee RM, Lu C, Su LY, Werstuck G, Gao YJ: Effects of hyperglycemia on the modulation of vascular function by perivascular adipose tissue. J Hypertens 2009;27:118-131.
21. Sun X, Yu Y, Han L: High FFA levels related to microalbuminuria and uncoupling of VEGF-NO axis in obese rats. Int Urol Nephrol 2013;45:1197-1207.
22. Li R, Wang WQ, Zhang H, Yang X, Fan Q, Christopher TA, Lopez BL, Tao L, Goldstein BJ, Gao F, Ma XL: Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity. Am J Physiol Endocrinol Metab 2007;293:E1703-1708.
23. Kono T, Saito M, Kinoshita Y, Satoh I, Shinbori C, Satoh K: Real-time monitoring of nitric oxide and blood flow during ischemia-reperfusion in the rat testis. Mol Cell Biochem 2006;286:139-145.
24. Abraham NG, Kushida T, McClung J, Weiss M, Quan S, Lafaro R, Darzynkiewicz Z, Wolin M: Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells. Circ Res 2003;93:507-514.
25. Ohara Y, Peterson TE, Harrison DG: Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993;91:2546-2551.
26. El MA, de Champlain J: Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid. Hypertension 2002;39:303-307.
27. Cooper-DeHoff RM, Pepine CJ: Metabolic syndrome and cardiovascular disease: challenges and opportunities. Clin Cardiol 2007;30:593-597.
28. Abraham NG, Kappas A: Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 2008;60:79-127.
29. Abraham NG, Rezzani R, Rodella L, Kruger A, Taller D, Li VG, Goodman AI, Kappas A: Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes. Am J Physiol Heart Circ Physiol 2004;287:H2468-2477.
30. L'Abbate A, Neglia D, Vecoli C, Novelli M, Ottaviano V, Baldi S, Barsacchi R, Paolicchi A, Masiello P, Drummond GS, McClung JA, Abraham NG: Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats. Am J Physiol Heart Circ Physiol 2007;293:H3532-3541.
31. Ouchi N: Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 2003;42:231234.
32. Ouedraogo R, Gong Y, Berzins B, Wu X, Mahadev K, Hough K, Chan L, Goldstein BJ, Scalia R: Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest 2007;117:1718-1726.
33. Pansuria M, Xi H, Li L, Yang XF, Wang H: Insulin resistance, metabolic stress, and atherosclerosis. Front Biosci (Schol Ed) 2012;4:916-931.
34. Yamauchi T, Kadowaki T: Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. Int J Obes (Lond) 2008;32:S13-18.
35. Berg AH, Combs TP, Scherer PE: ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002;13:84-89.
36. Stec DE, Vera T, McLemore GR Jr, Kelsen S, Rimoldi JM, Gadepalli RS, Ryan MJ: Heme oxygenase-1 induction does not improve vascular relaxation in angiotensin II hypertensive mice. Am J Hypertens 2008;21:189-193.
37. Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S: Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice. Circ Res 2001;89:55-62.