Rapid elevation of transferrin saturation and serum hepcidin concentration in hemodialysis patients after intravenous iron infusion

Haematologica

Volumn 100, Issue 3, 2015, Pages 80-83

  Kitsati, Natalia ^a   Liakos, Dimitrios ^b   Ermeidi, Eleni ^a   Mantzaris, Michalis D ^a   Vasakos, Spyros ^b   Kyratzopoulou, Eleni ^c   Eliadis, Petros ^c   Andrikos, Emilios ^b   Kokkolou, Elisavet ^b   Sferopoulos, Georgios ^b   Mamalaki, Avgi ^c   Siamopoulos, Konstantinos ^a   Galaris, Dimitrios ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b Hatzikosta Hospital   (Greece)

^c HELLENIC PASTEUR INSTITUTE   (Greece)

Author keywords

Hepcidin; Intravenous iron infusion; Iron administration

Indexed keywords

CD71 ANTIGEN; ERYTHROPOIETIN; HEPCIDIN; IRON SACCHARATE; PEPTIDE HORMONE; TRANSFERRIN; TRANSFERRIN RECEPTOR 2; UREA; HAP PROTEIN, HUMAN; IRON; IRON DEXTRAN; ISOPROTEIN; PLASMA PROTEIN;

CARDIOVASCULAR DISEASE; DEATH; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROBLAST; HEMODIALYSIS; HUMAN; INFLAMMATION; IRON BINDING CAPACITY; LETTER; LIVER CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; QUALITY OF LIFE; RETICULOENDOTHELIAL SYSTEM; WESTERN BLOTTING; ADVERSE EFFECTS; ANEMIA; BLOOD; GENE EXPRESSION; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FAILURE, CHRONIC; MALE; METABOLISM; PATHOLOGY; PROCEDURES;

ANEMIA; BLOOD PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION; HUMANS; INJECTIONS, INTRAVENOUS; IRON; IRON-DEXTRAN COMPLEX; KIDNEY FAILURE, CHRONIC; MALE; PROTEIN ISOFORMS; RENAL DIALYSIS; TRANSFERRIN;

EID: 84924658118     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2014.116806     Document Type: Letter

References (15)

1. Horl WH. Anaemia management and mortality risk in chronic kidney disease. Nat Rev Nephrol. 2013;9(5):291-301.
2. Sebastiani G, Pantopoulos K. Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice. Metallomics. 2011;3(10):971-986.
3. Ganz T. Systemic iron homeostasis. Physiol Rev. 2013;93(4):1721-1741.
4. Camaschella C. Iron and hepcidin: a story of recycling and balance. Hematology Am Soc Hematol Educ Program. 2013;2013:1-8.
5. Daba A, Gkouvatsos K, Sebastiani G, Pantopoulos K. Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing. J Mol Med (Berl). 2013;91(1):95-102.
6. Seligman PA, Schleicher RB. Comparison of methods used to measure serum iron in the presence of iron gluconate or iron dextran. Clin Chem. 1999;45(6 Pt 1):898-901.
7. Sunder-Plassmann G, Horl WH. Safety of intravenous injection of iron saccharate in haemodialysis patients. Nephrol Dial Transplant. 1996;11(9):1797-802.
8. Makey DG, Seal US. The detection of four molecular forms of human transferrin during the iron binding process. Biochim Biophys Acta. 1976;453(1):250-256.
9. Koliaraki V, Marinou M, Vassilakopoulos TP, et al. A novel immunological assay for hepcidin quantification in human serum. PLoS One. 2009;4(2):e4581.
10. Bartnikas TB, Andrews NC, Fleming MD. Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood. 2011;117(2):630-637.
11. Ganz T. Is TfR2 the iron sensor? Blood. 2004;104(13):3839-3840.
12. Scheiber-Mojdehkar B, Lutzky B, Schaufler R, Sturm B, Goldenberg H. Nontransferrin-bound iron in the serum of hemodialysis patients who receive ferric saccharate: no correlation to peroxide generation. J Am Soc Nephrol. 2004;15(6):1648-1655.
13. Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007;110(6):2182-2189.
14. Ramos E, Kautz L, Rodriguez R, et al. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology. 2011;53(4):1333-1341.
15. Singh A. Hemoglobin control, ESA resistance, and regular low-dose IV iron therapy: a review of the evidence. Semin Dial. 2009;22(1):64-69.