Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse

Physiological Genomics

Volumn 11, Issue , 2003, Pages 253-262

  Cvetkovic, Branimir ^a   Keen, Henry L ^a   Zhang, Xiaoji ^a   Davis, Deborah ^a   Yang, Baoli ^a   Sigmund, Curt D ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Genetics; Hypertension; Renin angiotensin system

Indexed keywords

AMINO ACID; ANGIOTENSINOGEN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; RENIN; MESSENGER RNA;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; EMBRYO; EXPERIMENTAL MOUSE; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENETICS; HAPLOTYPE; HUMAN; HYPERTENSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSGENE; ANIMAL; BIOSYNTHESIS; BLOOD; CELL LINE; COMPARATIVE STUDY; FEMALE; HEART; HEART MUSCLE; HISTOLOGY; KIDNEY; MALE; METABOLISM; ORGAN SIZE; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

ANGIOTENSINOGEN; ANIMALS; BLOOD PRESSURE; CELL LINE; FEMALE; GENE TARGETING; HAPLOTYPES; HEART; HUMANS; KIDNEY; MALE; MICE; MICE, TRANSGENIC; MYOCARDIUM; ORGAN SIZE; RENIN; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 0141816961     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00076.2002     Document Type: Article

References (46)

1. Azizi M, Hallouin MC, Jeunemaitre X, Guyene TT, and Menard J. Influence of the M235T polymorphism of human angiotensinogen (AGT) on plasma AGT and renin concentrations after ethinylestradiol administration. J Clin Endocrinol Metab 85: 4331-4337, 2000.
2. 235→Thr variant of angiotensinogen gene in severe, familial hypertension. Biochem Biophys Res Commun 197: 833-839, 1993.
3. Bloem LJ, Manatunga AK, Tewksbury DA, and Pratt JH. The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children. J Clin Invest 95: 948-953, 1995.
4. Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, Grobbee D, Schmidt S, Schunkert H, Schuster H, Sharma AM, and Soubrier F. Evaluation of the angiotensinogen locus in human essential hypertension: a European study. Hypertension 31: 725-729, 1998.
5. Bronson SK, Plaehn EG, Kluckman KD, Hagaman JR, Maeda N, and Smithies O. Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci USA 93: 9067-9072, 1996.
6. Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P, and Clark AJL. Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med 330: 1629-1633, 1994.
7. Caulfield M, Lavender P, Newell-Price J, Farrall M, Kamdar S, Daniel H, Lawson M, De Freitas P, Fogarty P, and Clark AJ. Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. J Clin Invest 96: 687-692, 1995.
8. Chiang FT, Hsu KL, Tseng CD, Hsiao WH, Lo HM, Chern TH, and Tseng YZ. Molecular variant M235T of the angiotensinogen gene is associated with essential hypertension in Taiwanese. J Hypertens 15: 607-611, 1997.
9. Cohen P, Badouaille G, Gimenez-Roqueplo AP, Mani JC, Guyene TT, Jeunemaitre X, Menard J, Corvol P, Pau B, and Simon D. Selective recognition of M235T angiotensinogen variants and their determination in human plasma by monoclonal antibody-based immunoanalysis. J Clin Endocrinol Metab 81: 3505-3512, 1996.
10. Cvetkovic B, Yang B, Williamson RA, and Sigmund CD. Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. J Biol Chem 275: 1073-1078, 2000.
11. Davisson RL, Yang G, Beltz TG, Cassell MD, Johnson AK, and Sigmund CD. The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circ Res 83: 1047-58, 1998.
12. Fernandez-Arcas N, Dieguez-Lucena JL, Munoz-Moran E, Ruiz-Galdon M, Espinosa-Caliani S, Aranda-Lara P, Rius-Diaz F, Gaitan-Arroyo MJ, Teresa-Galvan E, and Reyes-Engel A. Both alleles of the M235T polymorphism of the angiotensinogen gene can be a risk factor for myocardial infarction. Clin Genet 60: 52-57, 2001.
13. Fornage M, Turner ST, Sing CF, and Boerwinkle E. Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota. Hum Genet 96: 295-300, 1995.
14. Forrester T, McFarlane-Anderson N, Bennet F, Wilks R, Puras A, Cooper R, Rotimi C, Durazo R, Tewksbury D, and Morrison L. Angiotensinogen and blood pressure among blacks: findings from a community survey in Jamaica. J Hypertens 14: 315-321, 1996.
15. Gimenez-Roqueplo AP, Celerier J, Schmid G, Corvol P, and Jeunemaitre X. Role of cysteine residues in human angiotensinogen. Cys232 is required for angiotensinogen-pro major basic protein complex formation. J Biol Chem 273: 34480-34487, 1998.
16. Gimenez-Roqueplo AP, Leconte I, Cohen P, Simon D, Guyene TT, Celerier J, Pau B, Corvol P, Clauser E, and Jeunemaitre X. The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein. J Biol Chem 271: 9838-9844, 1996.
17. Hata A, Namikawa C, Sasaki M, Sato K, Nakamura T, Tamura K, and Lalouel JM. Angiotensinogen as a risk factor for essential hypertension in Japan. J Clin Invest 93: 1285-1287, 1994.
18. Hatae T, Takimoto E, Murakami K, and Fukamizu A. Comparative studies on species-specific reactivity between renin and angiotensinogen. Mol Cell Biochem 131: 43-47, 1994.
19. Hegele RA, Brunt JH, and Connelly PW. A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate. Circulation 90: 2207-2212, 1994.
20. Hegele RA, Harris SB, Hanley AJ, Sun F, Connelly PW, and Zinman B. Angiotensinogen gene variation associated with variation in blood pressure in aboriginal Canadians. Hypertension 29: 1073-1077, 1997.
21. Hingorani AD, Sharma P, Jia H, Hopper R, and Brown MJ. Blood pressure and the M235T polymorphism of the angiotensinogen gene. Hypertension 28: 907-911, 1996.
22. Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M, Cheng T, Ludwig EH, Sharma AM, Hata A, Jeunemaitre X, and Lalouel JM. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 99: 1786-1797, 1997.
23. Iwai N, Shimoike H, Ohmichi N, and Kinoshita M. Angiotensinogen gene and blood pressure in the Japanese population. Hypertension 25: 688-693, 1995.
24. Jeunemaitre X, Inoue I, Williams C, Charru A, Tichet J, Powers M, Sharma AM, Gimenez-Roqueplo AP, Hata A, Corvol P, and Lalouel JM. Haplotypes of angiotensinogen in essential hypertension. Am J Hum Genet 60: 1448-1460, 1997.
25. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, and Corvol P. Molecular basis of human hypertension: role of angiotensinogen. Cell 71: 169-180, 1992.
26. Johnson AG, Simons LA, Friedlander Y, Simons J, Davis DR, and MaCallum J. M235→T polymorphism of the angiotensinogen gene predicts hypertension in the elderly. J Hypertens 14: 1061-1065, 1996.
27. Kamitani A, Rakugi H, Higaki J, Yi Z, Mikami H, Miki T, and Ogihara T. Association analysis of a polymorphism of the angiotensinogen gene with essential hypertension in Japanese. J Hum Hypertens 8: 521-524, 1994.
28. Kiema TR, Kauma H, Rantala AO, Lilja M, Reunanen A, Kesaniemi YA, and Savolainen MJ. Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure. Hypertension 28: 1070-1075, 1996.
29. Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, and Smithies O. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 92: 2735-2739, 1995.
30. Liu Y, Qin W, Hou S, Shan G, Zhuo M, Chen Y, Cui C, Caidan L, and Qiu C. A-6G variant of the angiotensinogen gene and essential hypertension in Han, Tibetan, and Yi populations. Hypertens Res 24: 159-163, 2001.
31. Merrill DC, Thompson MW, Carney C, Schlager G, Robillard JE, and Sigmund CD. Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest 97: 1047-1055, 1996.
32. Morgan T, Craven C, Nelson L, Lalouel JM, and Ward K. Angiotensinogen T235 expression is elevated in decidual spiral arteries. J Clin Invest 100: 1406-1415, 1997.
33. Morise T, Takeuchi Y, and Takeda R. Rapid detection and prevalence of the variants of the angiotensinogen gene in patients with essential hypertension. J Intern Med 237: 175-180, 1995.
34. Nishiuma S, Kario K, Kayaba K, Nagio N, Shimada K, Matsuo T, and Matsuo. Effect of the angiotensinogen gene Met235→Thr variant on blood pressure and other cardiovascular risk factors in two Japanese populations. J Hypertens 13: 717-722, 1995.
35. Paillard F, Chansel D, Brand E, Benetos A, Thomas F, Czekalski S, Ardaillou R, and Soubrier F. Genotype-phenotype relationships for the renin-angiotensin-aldosterone system in a normal population. Hypertension 34: 423-429, 1999.
36. Rotimi C, Cooper R, Ogunbiyi O, Morrison L, Ladipo M, Tewksbury D, and Ward R. Hypertension, serum angiotensinogen, and molecular variants of the angiotensinogen gene among Nigerians. Circulation 95: 2348-2350, 1997.
37. Rotimi C, Morrison L, Cooper R, Oyejide C, Effiong E, Ladipo M, Osotemihen B, and Ward R. Angiotensinogen gene in human hypertension: lack of an association of the 235T allele among African Americans. Hypertension 24: 591-594, 1994.
38. Sato N, Katsuya T, Nakagawa T, Ishikawa K, Fu Y, Asai T, Fukuda M, Suzuki F, Nakamura Y, Higaki J, and Ogihara T. Nine polymorphisms of angiotensinogen gene in the susceptibility to essential hypertension. Life Sci 68: 259-272, 2000.
39. Schmidt S, Sharma AM, Zilch O, Beige J, Walla-Friedel M, Ganten D, Distler A, and Ritz E. Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset. Nephrol Dial Transplant 10: 1145-1148, 1995.
40. Schunkert H, Hense HW, Gimenez-Roqueplo AP, Stieber J, Keil U, Riegger GAJ, and Jeunemaitre X. The angiotensinogen T235 variant and the use of antihypertensive drugs in a population-based cohort. Hypertension 29: 628-633, 1997.
41. Sigmund CD. Manipulating genes to understand cardiovascular diseases: major approaches for introducing genes into cells. Hypertension 22: 599-607, 1993.
42. Sinn PL, Davis DR, and Sigmund CD. Highly regulated cell-type restricted expression of human renin in mice containing 140 kb or 160 kb P1 phage artificial chromosome transgenes. J Biol Chem 274: 35785-35793, 1999.
43. Wang JG and Staessen JA. Genetic polymorphisms in the renin-angiotensin system: relevance for susceptibility to cardiovascular disease. Eur J Pharmacol 410: 289-302, 2000.
44. Ward K, Hata A, Jeunemaitre X, Helin C, Nelson L, Namikawa C, Farrington PF, Ogasawara M, Suzumori K, Tomoda S, Berrebi S, Sasaki M, Corvol P, Lifton RP, and Lalouel JM. A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet 4: 59-61, 1993.
45. Yang G, Merrill DC, Thompson MW, Robillard JE, and Sigmund CD. Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem 269: 32497-32502, 1994.
46. Yang G and Sigmund CD. Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. Hypertension 31: 734-740, 1998.