Effect of continuous vs pulsed iontophoresis of treprostinil on skin blood flow

European Journal of Pharmaceutical Sciences

Volumn 72, Issue , 2015, Pages 21-26

  Kotzki, Sylvain ^a,c   Roustit, Matthieu ^a,b,c   Arnaud, Claire ^b,c   Godin Ribuot, Diane ^b,c   Cracowski, Jean Luc ^a,b,c  

^a GRENOBLE UNIVERSITY HOSPITAL   (France)

^b INSERM   (France)

^c UNIV GRENOBLE ALPES   (France)

Author keywords

Continuous current; Iontophoresis; Microcirculation; Periodic current; Prostacyclin

Indexed keywords

SODIUM CHLORIDE; TREPROSTINIL; ANTIHYPERTENSIVE AGENT; PROSTACYCLIN;

ANIMAL EXPERIMENT; ARTICLE; CONTINUOUS IONTOPHORESIS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; INTERMETHOD COMPARISON; IONTOPHORESIS; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; PRIORITY JOURNAL; PULSED IONTOPHORESIS; RAT; SKIN BLOOD FLOW; SKIN CONDUCTANCE; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD FLOW; DRUG EFFECTS; PROCEDURES; SKIN; VASCULARIZATION; WISTAR RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; EPOPROSTENOL; IONTOPHORESIS; MALE; RATS, WISTAR; REGIONAL BLOOD FLOW; SKIN;

EID: 84924559960     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.02.012     Document Type: Article

References (28)

1. S. Blaise, M. Roustit, C. Millet, C. Ribuot, J. Boutonnat, and J.-L.L. Cracowski Cathodal iontophoresis of treprostinil and iloprost induces a sustained increase in cutaneous flux in rats Br. J. Pharmacol. 162 2011 557 565
2. S. Blaise, M. Roustit, M. Hellmann, C. Millet, and J.-L.L. Cracowski Cathodal iontophoresis of treprostinil induces a sustained increase in cutaneous blood flux in healthy volunteers J. Clin. Pharmacol. 53 2013 58 66
3. L.-L.H. Chen, and Y.W. Chien Transdermal iontophoretic permeation of luteinizing hormone releasing hormone: characterization of electric parameters J. Control. Release 40 1996 187 198
4. Y.A. Chizmadzhev, A.V. Indenbom, P.I. Kuzmin, S.V. Galichenko, J.C. Weaver, and R.O. Potts Electrical properties of skin at moderate voltages: contribution of appendageal macropores Biophys. J. 74 1998 843 856
5. N. Dixit, V. Bali, S. Baboota, A. Ahuja, and J. Ali Iontophoresis - an approach for controlled drug delivery: a review Curr. Drug Deliv. 4 2007 1 10
6. S. Durand, B. Fromy, P. Bouyé, J.L. Saumet, P. Abraham, and P. Bouye Current-induced vasodilation during water iontophoresis (5 min, 0.10 mA) is delayed from current onset and involves aspirin sensitive mechanisms J. Vasc. Res. 39 2002 59 71
7. R.W. Glaser, S.L. Leikin, L.V. Chernomordik, V.F. Pastushenko, and A.I. Sokirko Reversible electrical breakdown of lipid bilayers: formation and evolution of pores Biochim. Biophys. Acta 940 1988 275 287
8. A.L. Herrick Vascular function in systemic sclerosis Curr. Opin. Rheumatol. 12 2000 527 533
9. H. Inada, A.H. Ghanem, and W.I. Higuchi Studies on the effects of applied voltage and duration on human epidermal membrane alteration/recovery and the resultant effects upon iontophoresis Pharm. Res. 11 1994 687 697
10. Y.N. Kalia, A. Naik, J. Garrison, and R.H. Guy Iontophoretic drug delivery Adv. Drug Deliv. Rev. 56 2004 619 658
11. M. Kanebako, T. Inagi, and K. Takayama Evaluation of skin barrier function using direct current I: effects of conductivity, voltage, distance between electrodes and electrode area Biol. Pharm. Bull. 25 2002 1456 1460
12. M. Kanebako, T. Inagi, and K. Takayama Evaluation of skin barrier function using direct current II: effects of duty cycle, waveform, frequency and mode Biol. Pharm. Bull. 25 2002 1623 1628
13. M. Kanebako, T. Inagi, and K. Takayama Evaluation of skin barrier function using direct current III: effects of electrode distance, boundary length and shape Biol. Pharm. Bull. 26 2003 518 522
14. P. Knoblauch, and F. Moll In vitro pulsatile and continuous transdermal delivery of buserelin by iontophoresis J. Control. Release 26 1993 203 212
15. S. Kotzki, M. Roustit, C. Arnaud, J. Boutonnat, S. Blaise, and D. Godin-Ribuot Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats J. Pharmacol. Exp. Ther. 346 2013 424 431
16. K. Laliberte, C. Arneson, R. Jeffs, T. Hunt, and M. Wade Pharmacokinetics and steady-state bioequivalence of treprostinil sodium (Remodulin) administered by the intravenous and subcutaneous route to normal volunteers J. Cardiovasc. Pharmacol. 44 2004 209 214
17. M. Manetti, I. Rosa, A.F. Milia, S. Guiducci, P. Carmeliet, and L. Ibba-Manneschi Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma? Ann. Rheum. Dis. 73 2014 1700 1709
18. M.A. Mathier, S. McDevitt, and R. Saggar Subcutaneous treprostinil in pulmonary arterial hypertension: practical considerations J. Heart Lung Transplant. 29 2010 1210 1217
19. A.K. Murray, A.L. Herrick, R.E. Gorodkin, T.L. Moore, and T.A. King Possible therapeutic use of vasodilator iontophoresis Microvasc. Res. 69 2005 89 94
20. A.K. Murray, T.L. Moore, T.A. King, and A.L. Herrick Vasodilator iontophoresis a possible new therapy for digital ischaemia in systemic sclerosis? Rheumatology (Oxford) 47 2008 76 79
21. V.B. Nair, and R. Panchagnula Influence of electrical parameters in the iontophoretic delivery of a small peptide: in vitro studies using arginine-vasopressin as a model peptide Farm (Società Chim Ital 1989) 59 2004 583 593
22. K. Okabe, H. Yamaguchi, and Y. Kawai New iontophoretic transdermal administration of the beta-blocker metoprolol J. Control. Release 4 1986 79 85
23. M. Roustit, S. Blaise, C. Arnaud, M. Hellmann, C. Millet, and D. Godin-Ribuot Iontophoresis of endothelin receptor antagonists in rats and men PLoS One 7 2012 e40792
24. M. Roustit, S. Blaise, and J.-L. Cracowski Trials and tribulations of skin iontophoresis in therapeutics Br. J. Clin. Pharmacol. 77 2014 63 71
25. M. Roustit, F. Gaillard-Bigot, S. Blaise, F. Stanke-Labesque, C. Cracowski, and C. Seinturier Cutaneous iontophoresis of treprostinil in systemic sclerosis: a proof-of-concept study Clin. Pharmacol. Ther. 95 2014 439 445
26. S. Sims, W. Higuchi, and V. Srinivasan Skin alteration and convective solvent flow effects during iontophoresis. 2. Monovalent anion and cation-transport across human skin Pharm. Res. 9 1992 1402 1409
27. F.M. Wigley, J.R. Seibold, R.A. Wise, D.A. McCloskey, and W.P. Dole Intravenous iloprost treatment of Raynaud's phenomenon and ischemic ulcers secondary to systemic sclerosis J. Rheumatol. 19 1992 1407 1414
28. C.A. Zakzewski, D.W. Amory, D.K. Jasaitis, and J.K. Li Iontophoretically enhanced transdermal delivery of an ACE inhibitor in induced hypertensive rabbits: preliminary report Cardiovasc. Drugs Ther. 6 1992 589 595