Effect of Momordica charantia fruits on streptozotocin-induced diabetes mellitus and its associated complications

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 7, Issue 3, 2015, Pages 356-363

  Mishra, Arvind ^a   Gautam, Sudeep ^a   Pal, Savita ^a   Mishra, Akansha ^a   Rawat, Arun Kumar ^a   Maurya, Rakesh ^a   Srivastava, Arvind Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Diabetes; High fructose diet; Hyperglycemia; Momordica charantia; Streptozotocin

Indexed keywords

GLUCOSE TRANSPORTER 4; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN RECEPTOR SUBSTRATE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; MOMORDICA CHARANTIA EXTRACT; PROTEIN KINASE B; STREPTOZOCIN; WATER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHEMOLUMINESCENCE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; FRUIT; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; INSULIN BLOOD LEVEL; MALE; MOMORDICA CHARANTIA; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL; WESTERN BLOTTING;

EID: 84924411194     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Stanko P, Holla LI. Bidirectional association between diabetes mellitus and inflammatory periodontal disease. A review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2014;158(1):35-8.
2. Alhazmi A, Stojanovski E, McEvoy M, Garg ML. The association between dietary patterns and type 2 diabetes: a systematic review and meta-analysis of cohort studies. J Hum Nutr Diet 2014;27:251-60.
3. Konate K, Yomalan K, Sytar O, Zerbo P, Brestic M, Patrick VD, et al. Free radicals scavenging capacity, antidiabetic and antihypersensitive activities of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea in an animal model of type 2 diabetes mellitus. J Evid Based Complimentary Altern Med 2014; http://dx.doi.org/10.1155/2014/867075.
4. Shrivastava SR, Shrivastava PS, Ramasamy J. Role of self-care in management of diabetes mellitus. J Diabetes Metab Disord 2013;12(14):1-5.
5. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TA, Reddy M, Lingaiah HKM, et al. Mean platelet volume in type 2 diabetes mellitus. J Lab Physicians 2012;4(1):5-9.
6. Cade WT. Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. J Am Phys Ther Assoc 2008;88(11):1322-35.
7. Zhang M, Zhang L, Wu B, Song H, An Z, Li S. Dapagliflozin treatment for type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Res Rev 2014;30:204-21.
8. Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Diabetes Care 2012;35:1364-79.
9. Pandey A, Tripathi P, Pandey R, Srivastava R, Goswami S. Alternative therapies useful in the management of diabetes: A systematic review. J Pharm Bioallied Sci 2011;3(4):504-12.
10. Rahman MMD, Sayeed MA, Biplab KP, Siddique SA. Antidiabetic and cytotoxic activities of methanolic extract of Tabernaemontana divaricata (L.) leaves in alloxan induced mice. Asian J Pharm Clin Res 2012;5(1):49-52.
11. Hamissou M, Smith AC, Carter Jr RE, Triplett II JK. Antioxidative properties of bitter gourd (Momordica charantia) and zucchini (Cucurbita pepo). Emirates J Food Agric 2013;25(9):641-7.
12. Kumar SD, Sharathnath KV, Yogeswaran P, Harani A, Sudhakar K, Sudha P, et al. A medical potency of Momordica charantia. Int J Pharm Sci Rev Res 2010;1(2):95-100.
13. Patel R, Mahobia N, Upwar N, Waseem N, Talaviya H, Patel Z. Analgesic and antipyretic activities of Momordica charantia Linn fruits. J Adv Pharm Tech Res 2010;1(4):415-8.
14. Costa JGM, Nascimento EMM, Campos AR, Rodrigues FFG. Antibacterial activity of Momordica charantia (Cucurbitaceae) extracts and fractions. J Basic Clin Pharm 2011;2(1):45-51.
15. Rahuja N, Mishra A, Gautam S, Tamrakar AK, Maurya R, Jain SK, et al. Antidiabetic activity in flowers of Nymphea rubra. Int J Pharm Sci Rev Res 2013;22(1):121-33.
16. Srivastava R, Srivastava SP, Jaiswal N, Mishra A, Maurya R, Srivastava AK. Antidiabetic and antidyslipidemic activities of Cuminum cyminum L in validated animal models. Med Chem Res 2011;20(9):1656-66.
17. Tiwari P, Rahuja N, Kumar R, Lakshmi V, Srivastava MN, Agarwal SC, et al. Search for antihyperglycemic activity of new flora and fauna. Indian J Sci Technol 2008;1(5):1-5.
18. Divi SM, Bellamkonda R, Dasireddy SK. Evaluation of antidiabetic and antihyperlipedemic potential of aqueous extract of moringa oleifera in fructose fed insulin resistant and STZ induced diabetic wistar rats: a comparative study. Asian J Pharm Clin Res 2012;5(1):67-72.
19. Patel J, Iyer A, Brown L. Evaluation of the chronic complications of diabetes in a high fructose diet in rats. Indian J Biochem Biophys 2009;46(1):66-72.
20. Reddy SS, Karuna R, Saralakumari D. Prevention of insulin resistance by ingesting aqueous extract of Ocimum sanctum to fructose fed rats. Horm Metab Res 2008;40:44-9.
21. Hoehn KL, Hohnen BC, Cederberg A, Wu LE, Turner N, Yuasa T, et al. IRS1-independent defects define major nodes of insulin resistance. Cell Metab 2008;7:421-33.