Antidiabetic and cytotoxic activities of methanolic extract of Tabernaemontana Divaricata (L.) leaves in alloxan induced mice

Asian Journal of Pharmaceutical and Clinical Research

Volumn 5, Issue 1, 2012, Pages 49-52

  Masudur Rahman, Md ^a   Sayeed, Mohammed Aktar ^a   Biplab, Kaishar Parvej ^a   Siddique, Saiful Alam ^a  

^a INTERNATIONAL ISLAMIC UNIVERSITY CHITTAGONG   (Bangladesh)

Author keywords

Alloxan; Antidiabetic; Cytotoxicity; Tabernaemontana divaricata

Indexed keywords

ALLOXAN; METFORMIN; PLANT EXTRACT; TABERNAEMONTANA DIVARICATA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DIABETES MELLITUS; DRUG DOSE COMPARISON; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; LC 50; MALE; MOUSE; NONHUMAN; SINGLE DRUG DOSE; TABERNAEMONTANA; TABERNAEMONTANA DIVARICATA; TREATMENT RESPONSE;

EID: 84856801815     PISSN: 09742441     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Anonymous. Diabetes now a global threat gets own day. Sunday Times of India 2006; 24: 11.
2. Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27(5).
3. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for 2000 and projections for 2030. Diabetes Care 2004; 27: 1047-1053.
4. L Pirart. Diabetes mellitus and its degenerative complieations: a prospective study of 4400 patients observed between 1947 and 1973. Diabetes Care 1978; 168-172.
5. Holman R.R. and Turner R.C., Oral Agents and Insulin in the Treatment of NIDDM. In: Pickup J. and G. Wiliams (Eds.), Textbook of Diabetes, Blackwell, Oxford, 1991; 407-469.
6. Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care 1989; 12: 553-564.
7. Arambewela LSR, Ranatunge T. Indole alkaloid from Tabernaemontana divaricata. Phytochemistry 1991; 3: 1740-1.
8. Kam TS, Anuradha S. Alkaloids from Tabernaemontana divaricata. Phytochemistry 1995; 4: 313-6.
9. Fulton DC, Kroon PA, Threlfall DR. Enzymological aspects of the redirection of terpenoid biosynthesis in elicitor-treated cultures of Tabernaemontana divaricata. Phytochemistry 1994; 35: 1183-6.
10. Sierra MI. Biochemical, molecular and physiological aspects of plant peroxidases. Geneva: Imprimerie National 1991.
11. Van Beek TA, Verpoorte R, Svendsen AB, Leeuwenberg AJ, Bisset NG. Tabernaemontana L. (Apocynaceae): a review of its taxonomy, phytochemistry, ethnobotany and pharmacology. J Ethnopharmacol 1984; 10: 1-156.
12. S Okonogi, W Neimkhum, W Niwatananun, S Yotsawimonwat. Biological Activities of Active Extracts from Stem of Tabernaemontana Divaricata. Journal of Metals, Materials and Minerals 2010; 20 (3): 201-206.
13. Khan MSA. Gastroprotective Effect of Tabernaemontana divaricata (Linn.) R.Br. Flower Methanolic Extract in Wistar Rats. British Journal of Pharmaceutical Research, 2011; 1(3): 88-98.
14. Sharker SM, Chakma S and Rahman AA. Phytochemical and antinociceptive study of leaves of Tabernaemontana divaricata (L). Journal of Medicinal Plants Research 2011; 5(2): 245-247.
15. Pratchayasakul W, Pongchaidecha A, Chattipakorn N, Chattipakorn SC. Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus. Indian J Med Res 2010; 131: 411-417.
16. Meyer BN, NR Ferrigni, JE Putnam, JE Jacobsen, DE Nichols and JL McLaughlin. Brine shrimp: A convenient general bioassay for active plants constituents. J. Med. Plant Res 1982; 45: 31-34.
17. Zhao GY, JK Rupprecht, JL McLaughlin and KV Wood. Additional bioactive compounds and trilobacin, a novel highly cytotoxic acetogenin, from the bark of Asimina triloba. J. Nat. Prod 1992; 55: 347-356.
18. WHO. Traditional medicine 2008. http://www.who.int/mediacentre/factsheets/fs134/en/
19. Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect 2001; 109 Suppl 1: 69-75. PMC 1240543. PMID 11250806.