Bright expression of CD91 identifies highly activated human dendritic cells that can be expanded by defensins

Immunology

Volumn 144, Issue 4, 2015, Pages 661-667

  Cappelletti, Monica ^a,b,c   Presicce, Pietro ^a,c   Calcaterra, Francesca ^a,b   Mavilio, Domenico ^a,b   Della Bella, Silvia ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

CD91; Defensins; Dendritic cells; Human neutrophil peptide 1; Human defensin 1

Indexed keywords

B7 ANTIGEN; BETA DEFENSIN 1; CD40 ANTIGEN; CD83 ANTIGEN; DEFENSIN; HLA DR ANTIGEN; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; RECOMBINANT HUMAN BETA DEFENSIN 1; RECOMBINANT HUMAN NEUTROPHIL PEPTIDE 1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ALPHA DEFENSIN; BETA DEFENSIN; DEFB1 PROTEIN, HUMAN; HUMAN NEUTROPHIL PEPTIDE 1; LRP1 PROTEIN, HUMAN;

ANTIGEN EXPRESSION; ARTICLE; CELL STIMULATION; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; INVESTIGATIVE PROCEDURES; MONOCYTE; PRIORITY JOURNAL; UPREGULATION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLASSIFICATION; DRUG EFFECTS; FLOW CYTOMETRY; IMMUNOLOGY; METABOLISM; PHENOTYPE; TIME FACTOR;

ALPHA-DEFENSINS; BETA-DEFENSINS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DENDRITIC CELLS; FLOW CYTOMETRY; HUMANS; LIPOPOLYSACCHARIDES; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; PHENOTYPE; RECOMBINANT PROTEINS; TIME FACTORS; UP-REGULATION;

EID: 84924370901     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12418     Document Type: Article

References (22)

1. Lillis AP, Van Duyn LB, Murphy-Ullrich JE, Strickland DK. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev 2008; 88:887-918.
2. Binder RJ, Han DK, Srivastava PK. CD91: a receptor for heat shock protein gp96. Nat Immunol 2000; 1:151-5.
3. Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 2001; 194:781-95.
4. 2-macroglobulin receptor. Blood 2002; 100:4026-32.
5. Herz J, Strickland DK. LRP: a multifunctional scavenger and signaling receptor. J Clin Invest 2001; 108:779-84.
6. Basu S, Binder RJ, Ramalingam T, Srivastava PK. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 2001; 14:303-13.
7. Robert J, Ramanayake T, Maniero GD, Morales H, Chida AS. Phylogenetic conservation of glycoprotein 96 ability to interact with CD91 and facilitate antigen cross-presentation. J Immunol 2008; 180:3176-82.
8. Maniecki MB, Moller HJ, Moestrup SK, Moller BK. CD163 positive subsets of blood dendritic cells: the scavenging macrophage receptors CD163 and CD91 are coexpressed on human dendritic cells and monocytes. Immunobiology 2006; 211:407-17.
9. Stebbing J, Gazzard B, Portsmouth S et al. Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor. Blood 2003; 102:1806-14.
10. Kebba A, Stebbing J, Rowland S et al. Expression of the common heat-shock protein receptor CD91 is increased on monocytes of exposed yet HIV-1-seronegative subjects. J Leukoc Biol 2005; 78:37-42.
11. Cirone M, Di Renzo L, Lotti LV et al. Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91. PLoS ONE 2012; 7:e31732.
12. 2-macroglobulin-antigen complexes pre-formed in vivo. PLoS ONE 2012; 7:e50365.
13. McNulty S, Colaco CA, Blandford LE, Bailey CR, Baschieri S, Todrik S. Heat-shock proteins as dendritic cell-targeting vaccines - getting warmer. Immunology 2013; 139:407-15.
14. Mei HF, Jin XB, Zhu JY, Zeng AH, Wu Q, Lu XM, Li XB, Shen J. β-defensin 2 as an adjuvant promotes anti-melanoma immune responses and inhibits the growth of implanted murine melanoma in vivo. PLoS ONE 2012; 7:e31328.
15. Presicce P, Giannelli S, Taddeo A, Villa ML, Della Bella S. Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91. J Leukoc Biol 2009; 86:941-8.
16. + hematopoietic progenitors stimulate greater cytolytic T lymphocyte activity in the absence of bioactive IL-12p70, by either single peptide presentation or cross-priming, than do dermal-interstitial or monocyte-derived dendritic cells. J Immunol 2004; 173:2780-91.
17. Dasgupta S, Navarrete AM, Andre S et al. Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica 2008; 93:83-9.
18. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392:245-52.
19. De Filippo A, Binder RJ, Camisaschi C et al. Human plasmacytoid dendritic cells interact with gp96 via CD91 and regulate inflammatory responses. J Immunol 2008; 181:6525-35.
20. Singh-Jasuja H, Scherer HU, Hilf N, Arnold-Schild D, Rammensee HG, Toes RE, Schild H. The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor. Eur J Immunol 2000; 30:2211-5.
21. Gorovoy M, Gaultier A, Campana WM, Firestein GS, Gonias SL. Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol 2010; 88:769-78.
22. Stebbing J, Gazzard B, Kim L et al. The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressors. Blood 2003; 101:4000-4.