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Volumn 8, Issue 2, 2015, Pages 155-158

Genome sequencing in myelodysplastic syndromes: Can molecular mutations predict benefit from hypomethylating agent therapy?

Author keywords

biomarkers; genome sequencing; hypomethylating agents; myelodysplastic syndromes; prognostication; TET2 mutation

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; HYPOMETHYLATING AGENT; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ONCOPROTEIN;

EID: 84924348784     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/17474086.2015.1016905     Document Type: Article
Times cited : (16)

References (24)
  • 1
    • 60349092901 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: Biology and treatment
    • Jadersten M, Hellstrom-Lindberg E. Myelodysplastic syndromes: biology and treatment. J Intern Med 2009;265(3): 307-28
    • (2009) J Intern Med , vol.265 , Issue.3 , pp. 307-328
    • Jadersten, M.1    Hellstrom-Lindberg, E.2
  • 2
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg P, Cox D, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997;89(6):2079-88
    • (1997) Blood , vol.89 , Issue.6 , pp. 2079-2088
    • Greenberg, P.1    Cox, D.2    Lebeau, M.M.3
  • 3
    • 78951473511 scopus 로고    scopus 로고
    • Epidemiology, natural history, and practice patterns of patients with myelodysplastic syndromes in 2010
    • Sekeres MA. Epidemiology, natural history, and practice patterns of patients with myelodysplastic syndromes in 2010. J Natl Compr Canc Netw 2011;9(1):57-63
    • (2011) J Natl Compr Canc Netw , vol.9 , Issue.1 , pp. 57-63
    • Sekeres, M.A.1
  • 4
    • 84883553823 scopus 로고    scopus 로고
    • Current therapy of myelodysplastic syndromes
    • Zeidan AM, Linhares Y, Gore SD. Current therapy of myelodysplastic syndromes. Blood Rev 2013;27(5):243-59
    • (2013) Blood Rev , vol.27 , Issue.5 , pp. 243-259
    • Zeidan, A.M.1    Linhares, Y.2    Gore, S.D.3
  • 5
    • 84880473776 scopus 로고    scopus 로고
    • Personalizing oncology: Perspectives and prospects
    • Mendelsohn J. Personalizing oncology: perspectives and prospects. J Clin Oncol 2013;31(15):1904-11
    • (2013) J Clin Oncol , vol.31 , Issue.15 , pp. 1904-1911
    • Mendelsohn, J.1
  • 6
    • 79952164235 scopus 로고    scopus 로고
    • Unraveling the molecular pathophysiology of myelodysplastic syndromes
    • Bejar R, Levine R, Ebert BL. Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol 2011;29(5):504-15
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 504-515
    • Bejar, R.1    Levine, R.2    Ebert, B.L.3
  • 7
    • 84893772765 scopus 로고    scopus 로고
    • Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
    • Haferlach T, Nagata Y, Grossmann V, et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia 2014;28(2):241-7
    • (2014) Leukemia , vol.28 , Issue.2 , pp. 241-247
    • Haferlach, T.1    Nagata, Y.2    Grossmann, V.3
  • 8
    • 84888219405 scopus 로고    scopus 로고
    • Clinical and biological implications of driver mutations in myelodysplastic syndromes
    • quiz 3699
    • Papaemmanuil E, Gerstung M, Malcovati L, et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood 2013;122(22): 3616-27; quiz 3699
    • (2013) Blood , vol.122 , Issue.22 , pp. 3616-3627
    • Papaemmanuil, E.1    Gerstung, M.2    Malcovati, L.3
  • 9
    • 79959794787 scopus 로고    scopus 로고
    • Clinical effect of point mutations in myelodysplastic syndromes
    • Bejar R, Stevenson K, Abdel-Wahab O, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med 2011;364(26):2496-506
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2496-2506
    • Bejar, R.1    Stevenson, K.2    Abdel-Wahab, O.3
  • 10
    • 84908247072 scopus 로고    scopus 로고
    • TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients
    • Bejar R, Lord A, Stevenson K, et al. TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood 2014;124(17): 2705-12
    • (2014) Blood , vol.124 , Issue.17 , pp. 2705-2712
    • Bejar, R.1    Lord, A.2    Stevenson, K.3
  • 11
    • 84911008768 scopus 로고    scopus 로고
    • Platelet count doubling after the first cycle of azacitidine therapy predicts eventual response and survival in patients with myelodysplastic syndromes and oligoblastic acute myeloid leukaemia but does not add to prognostic utility of the revised IPSS
    • Zeidan AM, Lee JW, Prebet T, et al. Platelet count doubling after the first cycle of azacitidine therapy predicts eventual response and survival in patients with myelodysplastic syndromes and oligoblastic acute myeloid leukaemia but does not add to prognostic utility of the revised IPSS. Br J Haematol 2014;167(1):62-8
    • (2014) Br J Haematol , vol.167 , Issue.1 , pp. 62-68
    • Zeidan, A.M.1    Lee, J.W.2    Prebet, T.3
  • 12
    • 78650172030 scopus 로고    scopus 로고
    • Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine
    • Itzykson R, Thepot S, Quesnel B, et al. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine. Blood 2011;117(2):403-11
    • (2011) Blood , vol.117 , Issue.2 , pp. 403-411
    • Itzykson, R.1    Thepot, S.2    Quesnel, B.3
  • 13
    • 84904042149 scopus 로고    scopus 로고
    • Comparison of the prognostic utility of the revised international prognostic scoring system and the French prognostic scoring system in azacitidine-treated patients with myelodysplastic syndromes
    • Zeidan AM, Lee JW, Prebet T, et al. Comparison of the prognostic utility of the revised international prognostic scoring system and the French prognostic scoring system in azacitidine-treated patients with myelodysplastic syndromes. Br J Haematol 2014;166(3):352-9
    • (2014) Br J Haematol , vol.166 , Issue.3 , pp. 352-359
    • Zeidan, A.M.1    Lee, J.W.2    Prebet, T.3
  • 14
    • 84897394182 scopus 로고    scopus 로고
    • Why methylation is not a marker predictive of response to hypomethylating agents
    • Voso MT, Santini V, Fabiani E, et al. Why methylation is not a marker predictive of response to hypomethylating agents. Haematologica 2014;99(4):613-19
    • (2014) Haematologica , vol.99 , Issue.4 , pp. 613-619
    • Voso, M.T.1    Santini, V.2    Fabiani, E.3
  • 15
    • 84891301466 scopus 로고    scopus 로고
    • The genetic basis of myelodysplasia and its clinical relevance
    • Cazzola M, Della Porta MG, Malcovati L. The genetic basis of myelodysplasia and its clinical relevance. Blood 2013;122(25): 4021-34
    • (2013) Blood , vol.122 , Issue.25 , pp. 4021-4034
    • Cazzola, M.1    Della Porta, M.G.2    Malcovati, L.3
  • 16
    • 84873995626 scopus 로고    scopus 로고
    • TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis
    • Kulasekararaj AG, Smith AE, Mian SA, et al. TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis. Br J Haematol 2013;160(5):660-72
    • (2013) Br J Haematol , vol.160 , Issue.5 , pp. 660-672
    • Kulasekararaj, A.G.1    Smith, A.E.2    Mian, S.A.3
  • 17
    • 79956291339 scopus 로고    scopus 로고
    • TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression
    • Jadersten M, Saft L, Smith A, et al. TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression. J Clin Oncol 2011;29(15): 1971-9
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 1971-1979
    • Jadersten, M.1    Saft, L.2    Smith, A.3
  • 18
    • 84923227505 scopus 로고    scopus 로고
    • Current state of prognostication and risk stratification in myelodysplastic syndromes
    • Zeidan AM, Gore SD, Padron E, et al. Current state of prognostication and risk stratification in myelodysplastic syndromes. Curr Opin Hematol 2015;22(2):146-54
    • (2015) Curr Opin Hematol , vol.22 , Issue.2 , pp. 146-154
    • Zeidan, A.M.1    Gore, S.D.2    Padron, E.3
  • 19
    • 84934302627 scopus 로고    scopus 로고
    • Lenalidomide induces ubiquitination and degradation of CSNK1A1 in MDS with Del(5q)
    • San Francisco, CA
    • Fink EC, Krönke J, Hurst SN, et al. Lenalidomide induces ubiquitination and degradation of CSNK1A1 in MDS with Del(5q). ASH Annual Meeting, San Francisco, CA; 2014
    • (2014) ASH Annual Meeting
    • Fink, E.C.1    Krönke, J.2    Hurst, S.N.3
  • 20
    • 84908006668 scopus 로고    scopus 로고
    • Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS
    • Schneider RK, Adema V, Heckl D, et al. Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. Cancer Cell 2014;26(4):509-20
    • (2014) Cancer Cell , vol.26 , Issue.4 , pp. 509-520
    • Schneider, R.K.1    Adema, V.2    Heckl, D.3
  • 21
    • 84906809218 scopus 로고    scopus 로고
    • Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation
    • Bejar R, Stevenson KE, Caughey B, et al. Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation. J Clin Oncol 2014;32(25):2691-8
    • (2014) J Clin Oncol , vol.32 , Issue.25 , pp. 2691-2698
    • Bejar, R.1    Stevenson, K.E.2    Caughey, B.3
  • 22
    • 79960229916 scopus 로고    scopus 로고
    • Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias
    • Itzykson R, Kosmider O, Cluzeau T, et al. Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia 2011;25(7):1147-52
    • (2011) Leukemia , vol.25 , Issue.7 , pp. 1147-1152
    • Itzykson, R.1    Kosmider, O.2    Cluzeau, T.3
  • 23
    • 84891876933 scopus 로고    scopus 로고
    • Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms
    • Traina F, Visconte V, Elson P, et al. Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms. Leukemia 2014;28(1):78-87
    • (2014) Leukemia , vol.28 , Issue.1 , pp. 78-87
    • Traina, F.1    Visconte, V.2    Elson, P.3
  • 24
    • 84895785721 scopus 로고    scopus 로고
    • Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine
    • Valencia A, Masala E, Rossi A, et al. Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine. Leukemia 2014;28(3):621-8
    • (2014) Leukemia , vol.28 , Issue.3 , pp. 621-628
    • Valencia, A.1    Masala, E.2    Rossi, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.