High-Risk coronary plaque at coronary CT angiography is associated with nonalcoholic fatty liver disease, independent of coronary plaque and stenosis burden: Results from the ROMICAT II Trial

Radiology

Volumn 274, Issue 3, 2015, Pages 693-701

  Puchner, Stefan B ^a,b   Lu, Michael T ^a   Mayrhofer, Thomas ^a,e   Liu, Ting ^a   Pursnani, Amit ^a   Ghoshhajra, Brian B ^a   Truong, Quynh A ^a   Wiviott, Stephen D ^a,c   Fleg, Jerome L ^a,d   Hoffmann, Udo ^a   Ferencik, Maros ^a,f  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e CHINA MEDICAL UNIVERSITY   (China)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOCARDIOGRAPHY; CLINICAL TRIAL; COMPLICATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; FEMALE; HUMAN; MALE; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; PHASE 2 CLINICAL TRIAL; PLAQUE, ATHEROSCLEROTIC; PROCEDURES; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT;

CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY STENOSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; PLAQUE, ATHEROSCLEROTIC; RISK ASSESSMENT; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84924340453     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.14140933     Document Type: Article

References (35)

1. Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology 2004;40(6):1387-1395
2. Younossi ZM, Diehl AM, Ong JP. Nonalcoholic fatty liver disease: An agenda for clinical research. Hepatology 2002;35(4):746-752
3. Wong VW, Hui AY, Tsang SW, et al. Metabolic and adipokine profile of Chinese patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2006;4(9):1154-1161
4. Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003;124(1):71-79
5. Pagano G, Pacini G, Musso G, et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association. Hepatology 2002;35(2):367-372
6. Park YS, Park SH, Lee SS, et al. Biopsyproven nonsteatotic liver in adults: estimation of reference range for difference in attenuation between the liver and the spleen at nonenhanced CT. Radiology 2011;258(3):760-766
7. Boyce CJ, Pickhardt PJ, Kim DH, et al. Hepatic steatosis (fatty liver disease) in asymptomatic adults identified by unenhanced low-dose CT. AJR Am J Roentgenol 2010;194(3):623-628
8. Zeb I, Li D, Nasir K, Katz R, Larijani VN, Budoff MJ. Computed tomography scans in the evaluation of fatty liver disease in a population based study: The multi-ethnic study of atherosclerosis. Acad Radiol 2012;19(7):811-818
9. Assy N, Djibre A, Farah R, Grosovski M, Marmor A. Presence of coronary plaques in patients with nonalcoholic fatty liver disease. Radiology 2010;254(2):393-400
10. Akabame S, Hamaguchi M, Tomiyasu K, et al. Evaluation of vulnerable coronary plaques and non-alcoholic fatty liver disease (NAFLD) by 64-detector multislice computed tomography (MSCT). Circ J 2008;72(4):618-625
11. Chhabra R, O'Keefe JH, Patil H, et al. Association of coronary artery calcification with hepatic steatosis in asymptomatic individuals. Mayo Clin Proc 2013;88(11):1259-1265
12. Liu J, Musani SK, Bidulescu A, et al. Fatty liver, abdominal adipose tissue and atherosclerotic calcification in African Americans: The Jackson Heart Study. Atherosclerosis 2012;224(2):521-525
13. Wong VW, Wong GL, Yip GW, et al. Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease. Gut 2011;60(12):1721-1727
14. Oni ET, Agatston AS, Blaha MJ, et al. A systematic review: Burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care? Atherosclerosis 2013;230(2):258-267
15. Achenbach S, Moselewski F, Ropers D, et al. Detection of calcified and noncalcified coronary atherosclerotic plaque by contrast- enhanced, submillimeter multidetector spiral computed tomography: A segmentbased comparison with intravascular ultrasound. Circulation 2004;109(1):14-17
16. Kim SY, Kim KS, Seung MJ, et al. The culprit lesion score on multi-detector computed tomography can detect vulnerable coronary artery plaque. Int J Cardiovasc Imaging 2010;26(Suppl 2):245-252
17. Pflederer T, Marwan M, Schepis T, et al. Characterization of culprit lesions in acute coronary syndromes using coronary dualsource CT angiography. Atherosclerosis 2010;211(2):437-444
18. Hoffmann U, Truong QA, Schoenfeld DA, et al. Coronary CT angiography versus stan dard evaluation in acute chest pain. N Engl J Med 2012;367(4):299-308
19. Raff GL, Abidov A, Achenbach S, et al. SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography. J Cardiovasc Comput Tomogr 2009;3(2): 122-136
20. Achenbach S, Ropers D, Hoffmann U, et al. Assessment of coronary remodeling in stenotic and nonstenotic coronary atherosclerotic lesions by multidetector spiral computed tomography. J Am Coll Cardiol 2004;43(5):842-847
21. Motoyama S, Sarai M, Harigaya H, et al. Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome. J Am Coll Cardiol 2009;54(1):49-57
22. Maurovich-Horvat P, Schlett CL, Alkadhi H, et al. The napkin-ring sign indicates advanced atherosclerotic lesions in coronary CT angiography. JACC Cardiovasc Imaging 2012;5(12):1243-1252
23. van Velzen JE, de Graaf FR, de Graaf MA, et al. Comprehensive assessment of spotty calcifications on computed tomography angiography: Comparison to plaque characteristics on intravascular ultrasound with radiofrequency backscatter analysis. J Nucl Cardiol 2011;18(5):893-903
24. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990;15(4):827-832
25. Liu J, Fox CS, Hickson D, Bidulescu A, Carr JJ, Taylor HA. Fatty liver, abdominal visceral fat, and cardiometabolic risk factors: The Jackson Heart Study. Arterioscler Thromb Vasc Biol 2011;31(11):2715-2722
26. Treeprasertsuk S, Leverage S, Adams LA, Lindor KD, St Sauver J, Angulo P. The Framingham risk score and heart disease in nonalcoholic fatty liver disease. Liver Int 2012;32(6):945-950
27. Jang S, Lee CH, Choi KM, et al. Correlation of fatty liver and abdominal fat distribution using a simple fat computed tomography protocol. World J Gastroenterol 2011;17(28): 3335-3341
28. Kim D, Choi SY, Park EH, et al. Nonalcoholic fatty liver disease is associated with coronary artery calcification. Hepatology 2012;56(2): 605-613
29. Sun L, Lü SZ. Association between nonalcoholic fatty liver disease and coronary artery disease severity. Chin Med J (Engl) 2011;124(6):867-872
30. Alkhouri N, Tamimi TA, Yerian L, Lopez R, Zein NN, Feldstein AE. The inflamed liver and atherosclerosis: A link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk. Dig Dis Sci 2010;55(9):2644-2650
31. Schindhelm RK, Dekker JM, Nijpels G, et al. Alanine aminotransferase predicts coronary heart disease events: A 10-year follow- up of the Hoorn Study. Atherosclerosis 2007;191(2):391-396
32. Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB. Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Lancet 1997;349(9050):462-466
33. Chiang CH, Huang CC, Chan WL, Chen JW, Leu HB. The severity of non-alcoholic fatty liver disease correlates with high sensitivity C-reactive protein value and is independently associated with increased cardiovascular risk in healthy population. Clin Biochem 2010;43(18):1399-1404
34. Bouki KP, Katsafados MG, Chatzopoulos DN, et al. Inflammatory markers and plaque morphology: An optical coherence tomography study. Int J Cardiol 2012;154(3):287-292
35. Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of the vulnerable plaque. J Am Coll Cardiol 2006;47(8,Suppl):C13-C18.