메뉴 건너뛰기




Volumn 17, Issue 4, 2015, Pages 369-381

Secretomes from bone marrow-derived mesenchymal stromal cells enhance periodontal tissue regeneration

Author keywords

Angiogenesis; Conditioned medium; Mesenchymal stromal cell; Migration; Paracrine effects; Periodontal regeneration

Indexed keywords

CD31 ANTIGEN; CELL PROTEIN; ENDOGLIN; GROWTH FACTOR; SCATTER FACTOR; SECRETOME; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; CONDITIONED MEDIUM; CYTOKINE; SIGNAL PEPTIDE; VASCULOTROPIN A;

EID: 84924295986     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2014.11.009     Document Type: Article
Times cited : (105)

References (50)
  • 2
    • 33646854590 scopus 로고    scopus 로고
    • The mechanism of bone resorption in chronic inflammation of periodontal disease
    • Kikuchi T., Mitani A., Noguchi T. The mechanism of bone resorption in chronic inflammation of periodontal disease. Clin Calcium 2006, 16:241-247.
    • (2006) Clin Calcium , vol.16 , pp. 241-247
    • Kikuchi, T.1    Mitani, A.2    Noguchi, T.3
  • 3
    • 0023992453 scopus 로고
    • Treatment of periodontal furcation defects. (II). Bone regeneration in mandibular class II defects
    • Gantes B., Martin M., Garrett S., Egelberg J. Treatment of periodontal furcation defects. (II). Bone regeneration in mandibular class II defects. JClin Periodontol 1988, 15:232-239.
    • (1988) JClin Periodontol , vol.15 , pp. 232-239
    • Gantes, B.1    Martin, M.2    Garrett, S.3    Egelberg, J.4
  • 4
    • 73249142844 scopus 로고    scopus 로고
    • Regeneration of periodontal tissues: guided tissue regeneration
    • Villar C.C., Cochran D.L. Regeneration of periodontal tissues: guided tissue regeneration. Dent Clin North Am 2010, 54:73-92.
    • (2010) Dent Clin North Am , vol.54 , pp. 73-92
    • Villar, C.C.1    Cochran, D.L.2
  • 5
    • 84886100415 scopus 로고    scopus 로고
    • An autologous platelet-rich plasma stimulates periodontal ligament regeneration
    • Anitua E., Troya M., Orive G. An autologous platelet-rich plasma stimulates periodontal ligament regeneration. JPeriodontol 2013, 84:1556-1566.
    • (2013) JPeriodontol , vol.84 , pp. 1556-1566
    • Anitua, E.1    Troya, M.2    Orive, G.3
  • 7
    • 0024725571 scopus 로고
    • Acombination of platelet-derived and insulin-like growth factors enhances periodontal regeneration
    • Lynch S.E., Williams R.C., Polson A.M., Howell T.H., Reddy M.S., Zappa U.E., et al. Acombination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. JClin Periodontol 1989, 16:545-548.
    • (1989) JClin Periodontol , vol.16 , pp. 545-548
    • Lynch, S.E.1    Williams, R.C.2    Polson, A.M.3    Howell, T.H.4    Reddy, M.S.5    Zappa, U.E.6
  • 8
    • 0030889908 scopus 로고    scopus 로고
    • Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs
    • Kinoshita A., Oda S., Takahashi K., Yokota S., Ishikawa I. Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs. JPeriodontol 1997, 68:103-109.
    • (1997) JPeriodontol , vol.68 , pp. 103-109
    • Kinoshita, A.1    Oda, S.2    Takahashi, K.3    Yokota, S.4    Ishikawa, I.5
  • 9
    • 0032134297 scopus 로고    scopus 로고
    • The effect of transforming growth factor beta one (TGF-beta[1]) on wound healing, with or without barrier membranes, in a Class II furcation defect in sheep
    • Mohammed S., Pack A.R.C., Kardos T.B. The effect of transforming growth factor beta one (TGF-beta[1]) on wound healing, with or without barrier membranes, in a Class II furcation defect in sheep. JPeriodontal Res 1998, 33:335-344.
    • (1998) JPeriodontal Res , vol.33 , pp. 335-344
    • Mohammed, S.1    Pack, A.R.C.2    Kardos, T.B.3
  • 10
    • 0031935104 scopus 로고    scopus 로고
    • Recombinant human osteogenic protein-1 stimulates periodontal wound healing in class III furcation defects
    • Giannobile W.V., Ryan S., Shih M.S., Su D.L., Kaplan P.L., Chan T.C.K. Recombinant human osteogenic protein-1 stimulates periodontal wound healing in class III furcation defects. JPeriodontol 1998, 69:129-137.
    • (1998) JPeriodontol , vol.69 , pp. 129-137
    • Giannobile, W.V.1    Ryan, S.2    Shih, M.S.3    Su, D.L.4    Kaplan, P.L.5    Chan, T.C.K.6
  • 11
    • 27744487950 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor enhances periodontal tissue regeneration
    • Takeda K., Shiba H., Mizuno N., Hasegawa N., Mouri Y., Hirachi A., et al. Brain-derived neurotrophic factor enhances periodontal tissue regeneration. Tissue Eng 2005, 11:1618-1629.
    • (2005) Tissue Eng , vol.11 , pp. 1618-1629
    • Takeda, K.1    Shiba, H.2    Mizuno, N.3    Hasegawa, N.4    Mouri, Y.5    Hirachi, A.6
  • 12
    • 30944432610 scopus 로고    scopus 로고
    • Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: Results of a large multicenter randomized controlled trial
    • Nevins M., Giannobile W.V., McGuire M.K., Kao R.T., Mellonig J.T., Hinrichs J.E., et al. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: Results of a large multicenter randomized controlled trial. JPeriodontol 2005, 76:2205-2215.
    • (2005) JPeriodontol , vol.76 , pp. 2205-2215
    • Nevins, M.1    Giannobile, W.V.2    McGuire, M.K.3    Kao, R.T.4    Mellonig, J.T.5    Hinrichs, J.E.6
  • 13
    • 79957901150 scopus 로고    scopus 로고
    • Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model
    • Tsumanuma Y., Iwata T., Washio K., Yoshida T., Yamada A., Takagi R., et al. Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model. Biomaterials 2011, 32:5819-5825.
    • (2011) Biomaterials , vol.32 , pp. 5819-5825
    • Tsumanuma, Y.1    Iwata, T.2    Washio, K.3    Yoshida, T.4    Yamada, A.5    Takagi, R.6
  • 15
    • 3042771201 scopus 로고    scopus 로고
    • Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet-rich plasma: Tissue-engineered bone regeneration
    • Yamada Y., Ueda M., Naiki T., Takahashi M., Hata K.I., Nagasaka T. Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet-rich plasma: Tissue-engineered bone regeneration. Tissue Eng 2004, 10:955-964.
    • (2004) Tissue Eng , vol.10 , pp. 955-964
    • Yamada, Y.1    Ueda, M.2    Naiki, T.3    Takahashi, M.4    Hata, K.I.5    Nagasaka, T.6
  • 16
    • 33847674118 scopus 로고    scopus 로고
    • Xenotransplantation of long-term-cultured swine bone marrow-derived mesenchymal stem cells
    • Nakamura Y., Wang X.H., Xu C.S., Asakura A., Yoshiyama M., From A.H., et al. Xenotransplantation of long-term-cultured swine bone marrow-derived mesenchymal stem cells. Stem Cells 2007, 25:612-620.
    • (2007) Stem Cells , vol.25 , pp. 612-620
    • Nakamura, Y.1    Wang, X.H.2    Xu, C.S.3    Asakura, A.4    Yoshiyama, M.5    From, A.H.6
  • 17
    • 77951628803 scopus 로고    scopus 로고
    • Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat
    • Ide C., Nakai Y., Nakano N., Seo T.B., Yamada Y., Endo K., et al. Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat. Brain Res 2010, 1332:32-47.
    • (2010) Brain Res , vol.1332 , pp. 32-47
    • Ide, C.1    Nakai, Y.2    Nakano, N.3    Seo, T.B.4    Yamada, Y.5    Endo, K.6
  • 18
    • 66149115190 scopus 로고    scopus 로고
    • Human CD133(+) Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling
    • Barcelos L.S., Duplaa C., Krankel N., Graiani G., Invernici G., Katare R., et al. Human CD133(+) Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling. Circ Res 2009, 104:1095-1099.
    • (2009) Circ Res , vol.104 , pp. 1095-1099
    • Barcelos, L.S.1    Duplaa, C.2    Krankel, N.3    Graiani, G.4    Invernici, G.5    Katare, R.6
  • 19
    • 59849115616 scopus 로고    scopus 로고
    • IFATS Collection: Human Adipose Tissue-Derived Stem Cells Induce Angiogenesis and Nerve Sprouting Following Myocardial Infarction, in Conjunction with Potent Preservation of Cardiac Function
    • Cai L.Y., Johnstone B.H., Cook T.G., Tan J., Fishbein M.C., Chen P.S., et al. IFATS Collection: Human Adipose Tissue-Derived Stem Cells Induce Angiogenesis and Nerve Sprouting Following Myocardial Infarction, in Conjunction with Potent Preservation of Cardiac Function. Stem Cells 2009, 27:230-237.
    • (2009) Stem Cells , vol.27 , pp. 230-237
    • Cai, L.Y.1    Johnstone, B.H.2    Cook, T.G.3    Tan, J.4    Fishbein, M.C.5    Chen, P.S.6
  • 20
    • 65549104457 scopus 로고    scopus 로고
    • Autologous Cell-Based Therapy for Ischemic Heart Disease: Clinical Evidence, Proposed Mechanisms of Action, and Current Limitations
    • Perin E.C., Silva G.V. Autologous Cell-Based Therapy for Ischemic Heart Disease: Clinical Evidence, Proposed Mechanisms of Action, and Current Limitations. Catheter Cardiovasc Interv 2009, 73:281-288.
    • (2009) Catheter Cardiovasc Interv , vol.73 , pp. 281-288
    • Perin, E.C.1    Silva, G.V.2
  • 21
    • 77954190127 scopus 로고    scopus 로고
    • Secretory Profiles and Wound Healing Effects of Human Amniotic Fluid-Derived Mesenchymal Stem Cells
    • Yoon B.S., Moon J.H., Jun E.K., Kim J., Maeng I., Kim J.S., et al. Secretory Profiles and Wound Healing Effects of Human Amniotic Fluid-Derived Mesenchymal Stem Cells. Stem Cells Dev 2010, 19:887-902.
    • (2010) Stem Cells Dev , vol.19 , pp. 887-902
    • Yoon, B.S.1    Moon, J.H.2    Jun, E.K.3    Kim, J.4    Maeng, I.5    Kim, J.S.6
  • 22
    • 66249097415 scopus 로고    scopus 로고
    • Novel Cell-Free Strategy for Therapeutic Angiogenesis: InVitro Generated Conditioned Medium Can Replace Progenitor Cell Transplantation
    • Di Santo S., Yang Z.J., von Ballmoos M.W., Voelzmann J., Diehm N., Baumgartner I., et al. Novel Cell-Free Strategy for Therapeutic Angiogenesis: InVitro Generated Conditioned Medium Can Replace Progenitor Cell Transplantation. PLoS One 2009, 4:11.
    • (2009) PLoS One , vol.4 , pp. 11
    • Di Santo, S.1    Yang, Z.J.2    von Ballmoos, M.W.3    Voelzmann, J.4    Diehm, N.5    Baumgartner, I.6
  • 23
    • 84867169164 scopus 로고    scopus 로고
    • InVivo Tumorigenesis Was Observed after Injection of InVitro Expanded Neural Crest Stem Cells Isolated from Adult Bone Marrow
    • Wislet-Gendebien S., Poulet C., Neirinckx V., Hennuy B., Swingland J.T., Laudet E., et al. InVivo Tumorigenesis Was Observed after Injection of InVitro Expanded Neural Crest Stem Cells Isolated from Adult Bone Marrow. PLoS One 2012, 7:13.
    • (2012) PLoS One , vol.7 , pp. 13
    • Wislet-Gendebien, S.1    Poulet, C.2    Neirinckx, V.3    Hennuy, B.4    Swingland, J.T.5    Laudet, E.6
  • 24
    • 84863884154 scopus 로고    scopus 로고
    • Conditioned Media from Mesenchymal Stem Cells Enhanced Bone Regeneration in Rat Calvarial Bone Defects
    • Osugi M., Katagiri W., Yoshimi R., Inukai T., Hibi H., Ueda M. Conditioned Media from Mesenchymal Stem Cells Enhanced Bone Regeneration in Rat Calvarial Bone Defects. Tissue Eng Part A 2012, 18:1479-1489.
    • (2012) Tissue Eng Part A , vol.18 , pp. 1479-1489
    • Osugi, M.1    Katagiri, W.2    Yoshimi, R.3    Inukai, T.4    Hibi, H.5    Ueda, M.6
  • 25
    • 84894095215 scopus 로고    scopus 로고
    • Novel Cell-Free Regeneration of Bone Using Stem Cell-Derived Growth Factors
    • Katagiri W., Osugi M., Kawai T., Ueda M. Novel Cell-Free Regeneration of Bone Using Stem Cell-Derived Growth Factors. Int J Oral Maxillofac Implants 2013, 28:1009-1016.
    • (2013) Int J Oral Maxillofac Implants , vol.28 , pp. 1009-1016
    • Katagiri, W.1    Osugi, M.2    Kawai, T.3    Ueda, M.4
  • 26
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003, 9:653-660.
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 27
    • 0032584132 scopus 로고    scopus 로고
    • Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts
    • Azizi S.A., Stokes D., Augelli B.J., DiGirolamo C., Prockop D.J. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts. Proc Natl Acad Sci U S A 1998, 95:3908-3913.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3908-3913
    • Azizi, S.A.1    Stokes, D.2    Augelli, B.J.3    DiGirolamo, C.4    Prockop, D.J.5
  • 30
    • 0038607621 scopus 로고    scopus 로고
    • Use of a new adhesive film for the preparation of multi-purpose fresh-frozen sections from hard tissues, whole-animals, insects and plants
    • Kawamoto T. Use of a new adhesive film for the preparation of multi-purpose fresh-frozen sections from hard tissues, whole-animals, insects and plants. Arch Histol Cytol 2003, 66:123-143.
    • (2003) Arch Histol Cytol , vol.66 , pp. 123-143
    • Kawamoto, T.1
  • 31
    • 3042749378 scopus 로고    scopus 로고
    • Investigation of multipotent postnatal stem cells from human periodontal ligament
    • Seo B.M., Miura M., Gronthos S., Bartold P.M., Batouli S., Brahim J., et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004, 364:149-155.
    • (2004) Lancet , vol.364 , pp. 149-155
    • Seo, B.M.1    Miura, M.2    Gronthos, S.3    Bartold, P.M.4    Batouli, S.5    Brahim, J.6
  • 32
    • 84902462911 scopus 로고    scopus 로고
    • Effects of Enamel Matrix Derivative and Basic Fibroblast Growth Factor with beta-Tricalcium Phosphate on Periodontal Regeneration in One-Wall Intrabony Defects: An Experimental Study in Dogs
    • Shirakata Y., Takeuchi N., Yoshimoto T., Taniyama K., Noguchi K. Effects of Enamel Matrix Derivative and Basic Fibroblast Growth Factor with beta-Tricalcium Phosphate on Periodontal Regeneration in One-Wall Intrabony Defects: An Experimental Study in Dogs. Int J Periodontics Restorative Dent 2013, 33:641-699.
    • (2013) Int J Periodontics Restorative Dent , vol.33 , pp. 641-699
    • Shirakata, Y.1    Takeuchi, N.2    Yoshimoto, T.3    Taniyama, K.4    Noguchi, K.5
  • 33
    • 0031711718 scopus 로고    scopus 로고
    • Effects of recombinant human bone morphogenetic protein-2 on differentiation of cells isolated from human bone, muscle, and skin
    • Kawasaki K., Aihara M., Honmo J., Sakurai S., Fujimaki Y., Sakamoto K., et al. Effects of recombinant human bone morphogenetic protein-2 on differentiation of cells isolated from human bone, muscle, and skin. Bone 1998, 23:223-231.
    • (1998) Bone , vol.23 , pp. 223-231
    • Kawasaki, K.1    Aihara, M.2    Honmo, J.3    Sakurai, S.4    Fujimaki, Y.5    Sakamoto, K.6
  • 34
    • 33847041526 scopus 로고    scopus 로고
    • Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study
    • Perri B., Cooper M., Lauryssen C., Anand N. Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study. Spine J 2007, 7:235-239.
    • (2007) Spine J , vol.7 , pp. 235-239
    • Perri, B.1    Cooper, M.2    Lauryssen, C.3    Anand, N.4
  • 35
    • 51449094036 scopus 로고    scopus 로고
    • Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model
    • Patel Z.S., Young S., Tabata Y., Jansen J.A., Wong M.E., Mikos A.G. Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model. Bone 2008, 43:931-940.
    • (2008) Bone , vol.43 , pp. 931-940
    • Patel, Z.S.1    Young, S.2    Tabata, Y.3    Jansen, J.A.4    Wong, M.E.5    Mikos, A.G.6
  • 37
    • 0026033552 scopus 로고
    • Invivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats
    • Spencer E.M., Liu C.C., Si E.C., Howard G.A. Invivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats. Bone 1991, 12:21-26.
    • (1991) Bone , vol.12 , pp. 21-26
    • Spencer, E.M.1    Liu, C.C.2    Si, E.C.3    Howard, G.A.4
  • 38
    • 33947700910 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells
    • Li Y., Yu X., Lin S., Li X., Zhang S., Song Y.H. Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells. Biochem Biophys Res Commun 2007, 356:780-784.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 780-784
    • Li, Y.1    Yu, X.2    Lin, S.3    Li, X.4    Zhang, S.5    Song, Y.H.6
  • 39
    • 0141742439 scopus 로고    scopus 로고
    • Role of insulin-like growth factor-1 signaling in dental fibroblast apoptosis
    • Han X.Z., Amar S. Role of insulin-like growth factor-1 signaling in dental fibroblast apoptosis. JPeriodontol 2003, 74:1176-1182.
    • (2003) JPeriodontol , vol.74 , pp. 1176-1182
    • Han, X.Z.1    Amar, S.2
  • 40
  • 42
    • 0030460424 scopus 로고    scopus 로고
    • Isolation of Angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    • Davis S., Aldrich T.H., Jones P.F., Acheson A., Compton D.L., Jain V., et al. Isolation of Angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 1996, 87:1161-1169.
    • (1996) Cell , vol.87 , pp. 1161-1169
    • Davis, S.1    Aldrich, T.H.2    Jones, P.F.3    Acheson, A.4    Compton, D.L.5    Jain, V.6
  • 43
    • 0032541165 scopus 로고    scopus 로고
    • Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2
    • Witzenbichler B., Maisonpierre P.C., Jones P., Yancopoulos G.D., Isner J.M. Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. JBiol Chem 1998, 273:18514-18521.
    • (1998) JBiol Chem , vol.273 , pp. 18514-18521
    • Witzenbichler, B.1    Maisonpierre, P.C.2    Jones, P.3    Yancopoulos, G.D.4    Isner, J.M.5
  • 45
    • 49149124199 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Karamysheva A.F. Mechanisms of angiogenesis. Biochemistry (Mosc) 2008, 73:751-762.
    • (2008) Biochemistry (Mosc) , vol.73 , pp. 751-762
    • Karamysheva, A.F.1
  • 46
    • 0032477844 scopus 로고    scopus 로고
    • Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor - The case for paracrine amplification of angiogenesis
    • Van Belle E., Witzenbichler B., Chen D.H., Silver M., Chang L., Schwall R., et al. Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor - The case for paracrine amplification of angiogenesis. Circulation 1998, 97:381-390.
    • (1998) Circulation , vol.97 , pp. 381-390
    • Van Belle, E.1    Witzenbichler, B.2    Chen, D.H.3    Silver, M.4    Chang, L.5    Schwall, R.6
  • 47
    • 0035102323 scopus 로고    scopus 로고
    • Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis invitro and invivo
    • Xin X.H., Yang S.Y., Ingle G., Zlot C., Rangell L., Kowalski J., et al. Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis invitro and invivo. Am J Pathol 2001, 158:1111-1120.
    • (2001) Am J Pathol , vol.158 , pp. 1111-1120
    • Xin, X.H.1    Yang, S.Y.2    Ingle, G.3    Zlot, C.4    Rangell, L.5    Kowalski, J.6
  • 50
    • 0037235343 scopus 로고    scopus 로고
    • Therapeutic angiogenesis using autologous bone marrow stromal cells: Improved blood flow in a chronic limb ischemia model
    • Al-Khaldi A., Al-Sabti H., Galipeau J., Lachapelle K. Therapeutic angiogenesis using autologous bone marrow stromal cells: Improved blood flow in a chronic limb ischemia model. Ann Thorac Surg 2003, 75:204-209.
    • (2003) Ann Thorac Surg , vol.75 , pp. 204-209
    • Al-Khaldi, A.1    Al-Sabti, H.2    Galipeau, J.3    Lachapelle, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.