Double umbilical cord blood transplantation: Relevance of persistent mixed-unit chimerism

Biology of Blood and Marrow Transplantation

Volumn 21, Issue 4, 2015, Pages 612-619

  Hashem, Hasan ^a   Lazarus, Hillard M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dominance; Double; Mixed chimerism; Transplantation; Umbilical cord blood

Indexed keywords

THYMOCYTE ANTIBODY; HLA ANTIGEN;

ADOPTIVE IMMUNOTHERAPY; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; BLOOD GROUP ABO INCOMPATIBILITY; CD3+ T LYMPHOCYTE; CELL COUNT; CELL VIABILITY; CHIMERA; CLINICAL TRIAL (TOPIC); COLONY FORMING UNIT GM; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOKINE PRODUCTION; DONOR SELECTION; DOUBLE UMBILICAL CORD BLOOD TRANSPLANTATION; GRAFT RECIPIENT; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HLA MATCHING; HLA SYSTEM; HLA TYPING; HUMAN; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; LEUKEMIA RELAPSE; RECURRENCE RISK; REDUCED INTENSITY CONDITIONING; REVIEW; T LYMPHOCYTE; UMBILICAL CORD BLOOD; ALLOGRAFT; GRAFT VERSUS HOST REACTION; HISTOCOMPATIBILITY;

ALLOGRAFTS; CORD BLOOD STEM CELL TRANSPLANTATION; GRAFT VS HOST DISEASE; GRAFT VS LEUKEMIA EFFECT; HLA ANTIGENS; HUMANS; TRANSPLANTATION CHIMERA;

EID: 84924290402     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2014.09.003     Document Type: Review

References (56)

1. Cohen G., Carter S.L., Weinberg K.I., et al. Antigen-specific T-lymphocyte function after cord blood transplantation. Biol Blood Marrow Transplant 2006, 12:1335-1342.
2. Eapen M., Rubinstein P., Zhang M.-J., et al. Outcomes of transplantation ofunrelated donor umbilical cord blood and bone marrow in childrenwith acute leukaemia: a comparison study. Lancet 2007, 369:1947-1954.
3. Kurtzberg J., Laughlin M., Graham M.L., et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. NEngl J Med 1996, 335:157-166.
4. Laughlin M.J., Barker J., Bambach B., et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. NEngl J Med 2001, 344:1815-1822.
5. Shpall EJ, Quinones R, Giller R, et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant. 2002;8(7):368-76. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24165586.
6. Brunstein C.G., Barker J.N., Weisdorf D.J., et al. Intra-BM injection to enhance engraftment after myeloablative umbilical cord blood transplantation with two partially HLA-matched units. Bone Marrow Transplant 2009, 43:935-940.
7. Delaney C., Heimfeld S., Brashem-Stein C., et al. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 2010, 16:232-236.
8. Norkin M., Lazarus H.M., Wingard J.R. Umbilical cord blood graft enhancement strategies: has the time come to move these into the clinic?. Bone Marrow Transplant 2013, 48:884-889.
9. Majhail N.S., Brunstein C.G., Wagner J.E. Double umbilical cord blood transplantation. Curr Opin Immunol 2006, 18:571-575.
10. Delaney C., Gutman J.A., Appelbaum F.R. Cord blood transplantation for haematological malignancies: conditioning regimens, double cord transplant and infectious complications. Br J Haematol 2009, 147:207-216.
11. Verneris M.R., Brunstein C.G., Barker J., et al. Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units. Blood 2009, 114:4293-4299.
12. Kindwall-Keller T.L., Hegerfeldt Y., Meyerson H.J., et al. Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies. Bone Marrow Transplant 2012, 47:924-933.
13. Baron F., Sandmaier B.M. Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning. Leukemia 2006, 20:1690-1700.
14. Barker J.N., Weisdorf D.J., DeFor T.E., et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005, 105:1343-1347.
15. Ballen K.K., Spitzer T.R., Yeap B.Y., et al. Double unrelated reduced-intensity umbilical cord blood transplantation in adults. Biol Blood Marrow Transplant 2007, 13:82-89.
16. Brunstein C.G., Barker J.N., Weisdorf D.J., et al. Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease. Blood 2007, 110:3064-3070.
17. Kang H.J., Kho S.H., Jang M.K., et al. Early engraftment kinetics of two units cord blood transplantation. Bone Marrow Transplant 2006, 38:197-201.
18. Gutman J a, Turtle C.J., Manley T.J., et al. Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit. Blood 2010, 115:757-765.
19. Kristt D., Gesundheit B., Stein J., et al. Quantitative monitoring of multi-donor chimerism: a systematic, validated framework for routine analysis. Bone Marrow Transplant 2010, 45:137-147.
20. Verneris M.R., Wagner J.E. UCB and atmospheric noise. Blood 2010, 115:754-755.
21. Y1 Yin, Ren H.Y., Cen X.A., et al. Long-term outcomes in adults with leukemia treated with transplantation of two unrelated umbilical cord blood units. Chin Med J (Engl) 2011, 124:2411-2416.
22. Wallet H.L., Sobh M., Morisset S., et al. Double umbilical cord blood transplantation for hematological malignancies: a long-term analysis from the SFGM-TC registry. Exp Hematol 2013, 41:924-933.
23. Song K., Sun Z., Liu H., et al. Primary research on unrelated double umbilical cord blood transplantation and implantation kinetics. Hematology 2013, 18:253-259.
24. Kai S., Wake A., Okada M., et al. Double-unit cord blood transplantation after myeloablative conditioning for patients with hematologic malignancies: a multicenter phase II study in Japan. Biol Blood Marrow Transplant 2013, 19:812-819.
25. Avery S., Shi W., Lubin M., et al. Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts. Blood 2011, 117:3277-3285. quiz 3478.
26. Ramirez P., Wagner J.E., Defor T.E., et al. Factors predicting single-unit predominance after double umbilical cord blood transplantation. Bone Marrow Transplant 2012, 47:799-803.
27. Scaradavou A., Smith K.M., Hawke R., et al. Cord blood units with low CD34+ cell viability have a low probability of engraftment after double unit transplantation. Biol Blood Marrow Transplant 2010, 16:500-508.
28. Kanda J., Rizzieri D.A., Gasparetto C., et al. Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning. Biol Blood Marrow Transplant 2011, 17:867-874.
29. Haspel R.L., Kao G., Yeap B.Y., et al. Preinfusion variables predict the predominant unit in the setting of reduced-intensity double cord blood transplantation. Bone Marrow Transplant 2008, 41:523-529.
30. Yoo K.H., Lee S.H., Kim H.-J., et al. The impact of post-thaw colony-forming units-granulocyte/macrophage on engraftment following unrelated cord blood transplantation in pediatric recipients. Bone Marrow Transplant 2007, 39:515-521.
31. Kim D.-W., Chung Y.-J., Kim T.-G., et al. Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation. Blood 2004, 103:1941-1948.
32. Nauta A.J., Kruisselbrink A.B., Lurvink E., et al. Enhanced engraftment ofumbilical cord blood-derived stem cells in NOD/SCID mice by cotransplantation of a second unrelated cord blood unit. Exp Hematol 2005, 33:1249-1256.
33. Hexner E.O., Danet-Desnoyers G.-A.H., Zhang Y., et al. Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation. Biol Blood Marrow Transplant 2007, 13:1135-1144.
34. Eldjerou L.K., Chaudhury S., Baisre-de Leon A., et al. An invivo model of double-unit cord blood transplantation that correlates with clinical engraftment. Blood 2010, 116:3999-4006.
35. Ho V.T. The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. Blood 2001, 98:3192-3204.
36. Moretta A., Andriolo G., Lisini D., et al. Invitro evaluation of graft-versus-graft alloreactivity as a tool to identify the predominant cord blood unit before double cord blood transplantation. Biol Blood Marrow Transplant 2012, 18:1108-1118.
37. Yahata T., Ando K., Miyatake H., et al. Competitive repopulation assay of two gene-marked cord blood units in NOD/SCID/gammac(null) mice. Mol Ther 2004, 10:882-891.
38. Ruggeri L. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2001, 295:2097-2100.
39. Willemze R., Rodrigues C.A., Labopin M., et al. KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia. Leukemia 2009, 23:492-500.
40. Newell L.F., Milano F., Nicoud I.B., et al. Early CD3 peripheral blood chimerism predicts the long-term engrafting unit following myeloablative double-cord blood transplantation. Biol Blood Marrow Transplant 2012, 18:1243-1249.
41. Milano F., Heimfeld S., Gooley T., et al. Correlation of infused CD3+CD8+ cells with single-donor dominance after double-unit cord blood transplantation. Biol Blood Marrow Transplant 2013, 19:156-160.
42. Yen H.-J., Chiou T.-J., Hung G.-Y., et al. Long-term mixed full-donor chimerism with dominance reversion after a double-unit cord blood transplant. Eur J Haematol 2008, 80:366-367.
43. Gertow J., Berglund S., Okas M., et al. Characterization of long-term mixed donor-donor chimerism after double cord blood transplantation. Clin Exp Immunol 2010, 162:146-155.
44. Berglund S., Okas M., Gertow J., et al. Stable mixed donor-donor chimerism after double cord blood transplantation. Int J Hematol 2009, 90:526-531.
45. Arachchillage D.R.J., Dalley C.D., Reilly J.T., et al. Long-term dual donor derived haematopoietic reconstitution following double unrelated cord blood transplantation-single unit dominance is not always the case. BrJ Haematol 2010, 149:298-299.
46. Kang H.J., Yoo K.H., Lee J.W., et al. Double umbilical cord blood transplantation for children and adolescents. Ann Hematol 2010, 89:1035-1044.
47. Yadav S.P., Dhingra N., Saxena R., Sachdeva A. Persistence of both cords nine months post double cord blood transplantation for juvenile myelomonocytic leukaemia. Hematol Oncol Stem Cell Ther 2013, 6:79-80.
48. Ponce D.M., Gonzales A., Lubin M., et al. Graft-versus-host disease after double-unit cord blood transplantation has unique features and an association with engrafting unit-to-recipient HLA match. Biol Blood Marrow Transplant 2013, 19:904-911.
49. Gertow J., Mattsson J.J., Uhlin M. Stable mixed double donor chimerism: Absence of war doesn't necessarily mean peace. Chimerism 2010, 1:64-65.
50. Ringdén O., Okas M., Uhlin M., et al. Unrelated cord blood and mismatched unrelated volunteer donor transplants, two alternatives in patients who lack an HLA-identical donor. Bone Marrow Transplant 2008, 42:643-648.
51. Verneris M.R. Natural killer cells and regulatory T cells: how to manipulate a graft for optimal GVL. Hematology Am Soc Hematol Educ Program 2013, 2013:335-341.
52. Eapen M., Klein J.P., Sanz G.F., et al. Effect of donor-recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis. Lancet Oncol 2011, 12:1214-1221.
53. Sideri A., Neokleous N., Brunet De La Grange P., et al. An overview of the progress on double umbilical cord blood transplantation. Haematologica 2011, 96:1213-1220.
54. Neokleous N., Sideri A., Peste-Tsilimidos C. Double cord blood transplantation: co-operation or competition?. Hematol Rep 2011, 3:e6.
55. Jens G., Arwen S., Emma W., Jonas M. Mixed chimerism after allogeneic stem cell transplantation - focus on double cord blood transplantation. JBlood Disord Transfus 2012, 01:1-7.
56. Ramirez P.A., Wagner J.E., Defor T., et al. Kinetics of chimerism and unit predominance after double umbilical cord blood transplantation. Blood 2010, 116. [abstract].