Salvianolic acid B promotes bone formation by increasing activity of alkaline phosphatase in a rat tibia fracture model: A pilot study

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  He, Xufeng ^a   Shen, Qiang ^b  

^a SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Alkaline phosphatase; Fracture healing; Radix salviae miltiorrhizae; Salvianolic acid B

Indexed keywords

ALKALINE PHOSPHATASE; SALVIANOLIC ACID B; BENZOFURAN DERIVATIVE; DAN-SHEN ROOT EXTRACT; HERBACEOUS AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE MATRIX; BONE REMODELING; CALLUS; CARTILAGE CELL; CELLULAR SECRETION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; MALE; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; PILOT STUDY; RAT; SCORING SYSTEM; TIBIA FRACTURE; WEIGHT GAIN; ANIMAL; BONE DEVELOPMENT; CHEMISTRY; DRUG EFFECTS; FRACTURE HEALING; FRACTURES, BONE; HUMAN; METABOLISM; PHYTOTHERAPY; SALVIA MILTIORRHIZA; SPRAGUE DAWLEY RAT; TIBIA;

ALKALINE PHOSPHATASE; ANIMALS; BENZOFURANS; BONY CALLUS; DRUGS, CHINESE HERBAL; FRACTURE HEALING; FRACTURES, BONE; HUMANS; MALE; OSTEOGENESIS; PHYTOTHERAPY; PILOT PROJECTS; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; TIBIA;

EID: 84924283117     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-493     Document Type: Article

References (29)

1. Zhou L, Zuo Z, Chow MS: Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 2005,45(12):1345-1359. 10.1177/0091270005282630
2. Wu B, Liu M, Zhang S: Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007., 2: CD004295
3. Wang C, Zhao X, Mao S, Wang Y, Cui X, Pu Y: Management of SAH with traditional Chinese medicine in China. Neurol Res 2006,28(4):436-444. 10.1179/016164106X115044
4. Xing HC, Li LJ, Xu KJ, Shen T, Chen YB, Chen Y, Fu SZ, Sheng JF, Chen CL, Wang JG: Effects of Salvia miltiorrhiza on intestinal microflora in rats with ischemia/reperfusion liver injury. Hepatobiliary Pancreatol Dis Int 2005,4(2):274-280.
5. Chen CG, Wang YP: Magnesium lithospermate B ameliorates renal cortical microperfusion in rats. Acta Pharmacol Sin 2006,27(2):217-222. 10.1111/j.1745-7254.2006.00225.x
6. Hoffmann SC, Kampen RL, Amur S, Sharaf MA, Kleiner DE, Hunter K, John Swanson S, Hale DA, Mannon RB, Blair PJ: Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury. Transplantation 2002,74(7):916-923. 10.1097/00007890-200210150-00003
7. Bando Y, Tsukamoto Y, Katayama T, Ozawa K, Kitao Y, Hori O, Stern DM, Yamauchi A, Ogawa S: ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death. FASEB J 2004,18(12):1401-1403.
8. Chen Y, Ruan Y, Li L, Chu Y, Xu X, Wang Q, Zhou X: Effects of Salvia miltiorrhiza extracts on rat hypoxic pulmonary hypertension, heme oxygenase-1 and nitric oxide synthase. Chin Med J (Engl) 2003,116(5):757-760.
9. Reignier J, Sellak H, Lemoine R, Lubineau A, Mazmanian GM, Detruit H, Chapelier A, Herve P: Prevention of ischemia-reperfusion lung injury by sulfated Lewis(a) pentasaccharide. The Paris-Sud University Lung Transplantation Group. J Appl Physiol 1997,82(4):1058-1063.
10. Shi W, Fu S, Du N: Effect of effective fraction of Radix Salviae Miltiorrhizae on procollagen gene expression in fracture healing. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000,20(4):269-271.
11. Zhang JY: Effect of Salvia miltiorrhiza root on calcium deposition in experimental fracture healing. Zhong Xi Yi Jie He Za Zhi 1984,4(9):536. -539, 515
12. Chan K, Chui SH, Wong DY, Ha WY, Chan CL, Wong RN: Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction. Life Sci 2004,75(26):3157-3171. 10.1016/j.lfs.2004.06.010
13. Kamata K, Iizuka T, Nagai M, Kasuya Y: Endothelium-dependent vasodilator effects of the extract from Salviae Miltiorrhizae radix. A study on the identification of lithospermic acid B in the extracts. Gen Pharmacol 1993,24(4):977-981. 10.1016/0306-3623(93)90176-X
14. Hu P, Luo GA, Zhao Z, Jiang ZH: Quality assessment of radix salviae miltiorrhizae. Chem Pharm Bull (Tokyo) 2005,53(5):481-486. 10.1248/cpb.53.481
15. Lam FF, Yeung JH, Chan KM, Or PM: Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels. Vasc Pharmacol 2007,46(4):271-277. 10.1016/j.vph.2006.10.011
16. Li YG, Song L, Liu M, Hu ZB, Wang ZT: Advancement in analysis of Salviae miltiorrhizae Radix et Rhizoma (Danshen). J Chromatogr A 2009,1216(11):1941-1953. 10.1016/j.chroma.2008.12.032
17. Ho JH, Hong CY: Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection. J Biomed Sci 2011, 18:30. 10.1186/1423-0127-18-30
18. Ji XY, Tan BK, Zhu YZ: Salvia miltiorrhiza and ischemic diseases. Acta Pharmacol Sin 2000,21(12):1089-1094.
19. Zhong J, Tang MK, Zhang Y, Xu QP, Zhang JT: Effect of salvianolic acid B on neural cells damage and neurogenesis after brain ischemia-reperfusion in rats. Yao Xue Xue Bao 2007,42(7):716-721.
20. Cui L, Li T, Liu Y, Zhou L, Li P, Xu B, Huang L, Chen Y, Tian X, Jee WS: Salvianolic acid B prevents bone loss in prednisone-treated rats through stimulation of osteogenesis and bone marrow angiogenesis. PLoS One 2012,7(4):e34647. 10.1371/journal.pone.0034647
21. Bonnarens F, Einhorn TA: Production of a standard closed fracture in laboratory animal bone. J Orthop Res 1984,2(1):97-101. 10.1002/jor.1100020115
22. Allen HL, Wase A, Bear WT: Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand 1980,51(4):595-600.
23. Oni OO, Stafford H, Gregg PJ: An experimental study of the patterns of periosteal and endosteal damage in tibial shaft fractures using a rabbit trauma model. J Orthop Trauma 1989,3(2):142-147. 10.1097/00005131-198906000-00009
24. Moss DW: Diagnostic aspects of alkaline phosphatase and its isoenzymes. Clin Biochem 1987,20(4):225-230. 10.1016/S0009-9120(87)80002-4
25. Viateau V, Guillemin G, Yang YC, Bensaid W, Reviron T, Oudina K, Meunier A, Sedel L, Petite H: A technique for creating critical-size defects in the metatarsus of sheep for use in investigation of healing of long-bone defects. Am J Vet Res 2004,65(12):1653-1657. 10.2460/ajvr.2004.65.1653
26. Yang Q, Wang S, Xie Y, Wang J, Li H, Zhou X, Liu W: Effect of salvianolic Acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin. Int J Mol Sci 2010,11(10):3696-3704. 10.3390/ijms11103696
27. Pan C, Lou L, Huo Y, Singh G, Chen M, Zhang D, Wu A, Zhao M, Wang S, Li J: Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways. Ther Adv Cardiovasc Dis 2011,5(2):99-111. 10.1177/1753944710396538
28. Westerhuis RJ, van Bezooijen RL, Kloen P: Use of bone morphogenetic proteins in traumatology. Injury 2005,36(12):1405-1412. 10.1016/j.injury.2005.02.047
29. Schmidmaier G, Wildemann B, Heeger J, Gabelein T, Flyvbjerg A, Bail HJ, Raschke M: Improvement of fracture healing by systemic administration of growth hormone and local application of insulin-like growth factor-1 and transforming growth factor-beta1. Bone 2002,31(1):165-172. 10.1016/S8756-3282(02)00798-6