Notch3 functions as a regulator of cell self-renewal by interacting with the β-catenin pathway in hepatocellular carcinoma

Oncotarget

Volumn 6, Issue 6, 2015, Pages 3669-3679

  Zhang, Qingyu ^a   Lu, Caijie ^a   Fang, Tao ^a   Wang, Yongcun ^a   Hu, Wenhua ^a   Qiao, Jie ^a   Liu, Bin ^a   Liu, Jie ^a   Chen, Nianping ^a   Li, Mingyi ^a   Zhu, Runzhi ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Beta catenin; Cancer stem cells; Hepatocellular carcinoma; Notch3

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALPHA FETOPROTEIN; BETA CATENIN; CISPLATIN; NOTCH3 RECEPTOR; TRANSCRIPTION FACTOR NANOG; ANTINEOPLASTIC AGENT; CTNNB1 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; NANOG PROTEIN, HUMAN; NOTCH RECEPTOR; NOTCH3 PROTEIN, HUMAN;

ANTIBIOTIC SENSITIVITY; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER PROGNOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME INACTIVATION; ENZYME REGULATION; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION; WNT SIGNALING PATHWAY; BIOSYNTHESIS; CANCER STEM CELL; CARCINOMA, HEPATOCELLULAR; FEMALE; GENETICS; HEP-G2 CELL LINE; LIVER NEOPLASMS; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; FEMALE; HEP G2 CELLS; HOMEODOMAIN PROTEINS; HUMANS; LIVER NEOPLASMS; MALE; NANOG HOMEOBOX PROTEIN; NEOPLASTIC STEM CELLS; RECEPTOR, NOTCH3; RECEPTORS, NOTCH; WNT SIGNALING PATHWAY;

EID: 84924235020     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2898     Document Type: Article

References (24)

1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. Journal of viral hepatitis. 2004; 11:97-107.
2. Yoon SK. The biology of cancer stem cells and its clinical implication in hepatocellular carcinoma. Gut and liver. 2012; 6:29-40.
3. + Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation. Cell Stem Cell. 2011; 9:50-63.
4. Neumeister V, Agarwal S, Bordeaux J, Camp RL, Rimm DL. In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor Prognosis. The American journal of pathology. 2010; 176:2131-2138.
5. Yang X-R, Xu Y, Yu B, Zhou J, Qiu S-J, Shi G-M, Zhang B-H, Wu W-Z, Shi Y-H, Wu B. High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma. Gut. 2010; 59:953-962.
6. Maillard I, Fang T, Pear WS. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol. 2005; 23:945-974.
7. Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa JL, Maroto M. Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS genetics. 2009; 5:e1000662.
8. Penton AL, Leonard LD, Spinner NB. Notch signaling in human development and disease. Seminars in cell & developmental biology. 2012; 23:450-457.
9. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J. TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell. 1991; 66:649-661.
10. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. nature. 2001; 414:105-111.
11. Stylianou S, Clarke RB, Brennan K. Aberrant activation of notch signaling in human breast cancer. Cancer research. 2006; 66:1517-1525.
12. McGuire WP, Hoskins WJ, Brady MF, Kucera PR, Partridge EE, Look KY, Clarke-Pearson DL, Davidson M. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. New England Journal of Medicine. 1996; 334:1-6.
13. Li L, Xie T. Stem cell niche: structure and function. Annu Rev Cell Dev Biol. 2005; 21:605-631.
14. Wang Z, Banerjee S, Li Y, Rahman KW, Zhang Y, Sarkar FH. Down-regulation of Notch-1 inhibits invasion by inactivation of nuclear factor-κB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer research. 2006; 66:2778-2784.
15. Allenspach EJ, Maillard I, Aster JC, Pear WS. Notch signaling in cancer. Cancer biology & therapy. 2002; 1:466-476.
16. Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV, Chomienne C, Ishikawa F, Schuringa JJ, Stassi G, Huntly B, Herrmann H, Soulier J, Roesch A, Schuurhuis GJ, Wohrer S, et al. Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer. 2012; 12:767-775.
17. Yang Z-J, Wechsler-Reya RJ. Hit'em where they live: targeting the cancer stem cell niche. Cancer cell. 2007; 11:3-5.
18. Pannuti A, Foreman K, Rizzo P, Osipo C, Golde T, Osborne B, Miele L. Targeting Notch to target cancer stem cells. Clinical Cancer Research. 2010; 16:3141-3152.
19. Jouve C, Palmeirim I, Henrique D, Beckers J, Gossler A, Ish-Horowicz D, Pourquié O. Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm. Development. 2000; 127:1421-1429.
20. Ohtsuka T, Ishibashi M, Gradwohl G, Nakanishi S, Guillemot F, Kageyama R. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. The EMBO journal. 1999; 18:2196-2207.
21. Terris B, Cavard C, Perret C. EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma. Journal of hepatology. 2010; 52:280-281.
22. Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, Jia H, Ye Q, Qin LX, Wauthier E. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology. 2009; 136:1012-1024e1014.
23. Kielman MF, Rindapää M, Gaspar C, van Poppel N, Breukel C, van Leeuwen S, Taketo MM, Roberts S, Smits R, Fodde R. Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling. Nature genetics. 2002; 32:594-605.
24. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W. β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001; 105:533-545.