A novel atypical hemolytic uremic syndrome-associated hybrid CFHR1/CFH gene encoding a fusion protein that antagonizes factor H-dependent complement regulation

Journal of the American Society of Nephrology

Volumn 26, Issue 1, 2015, Pages 209-219

  Valoti, Elisabetta ^a   Alberti, Marta ^a   Tortajada, Agustin ^b   Garcia Fernandez, Jesus ^b   Gastoldi, Sara ^a   Besso, Luca ^c   Bresin, Elena ^a   Remuzzi, Giuseppe ^a,d   Rodriguez De Cordoba, Santiago ^b   Noris, Marina ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c MOLINETTE HOSPITAL   (Italy)

^d Azienda Ospedaliera Papa Giovanni XXIII   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CLONIDINE; COMPLEMENT FACTOR H; COMPLEMENT MEMBRANE ATTACK COMPLEX; DOXAZOSIN; ECULIZUMAB; FHR1 FH HYBRID PROTEIN; HYBRID PROTEIN; MEMBRANE COFACTOR PROTEIN; MINOXIDIL; NIFEDIPINE; STEROID; UNCLASSIFIED DRUG; CFHR1 PROTEIN, HUMAN; CHIMERIC PROTEIN; COMPLEMENT; COMPLEMENT FACTOR I;

ADULT; ANIMAL CELL; ARTICLE; CELL SURFACE; CFHR1 CFH FUSION GENE; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; COMPLEMENT DEPOSITION; COMPLEMENT HEMOLYSIS TEST; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENDOTHELIUM CELL; ERYTHROCYTE CONCENTRATE; EXON; FAMILY; FEMALE; GENE DUPLICATION; GENE MAPPING; GENE REARRANGEMENT; GENETIC RISK; GENETIC SCREENING; GENOME ANALYSIS; GENOTYPE; HAPLOTYPE; HEMODIALYSIS; HEMOLYTIC UREMIC SYNDROME; HETEROZYGOTE; HIGH RISK PATIENT; HUMAN; HYBRID GENE; INFANT; INTRON; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; NONHUMAN; PATHOGENESIS; PEDIGREE; PLASMA TRANSFUSION; PLASMAPHERESIS; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROGNOSIS; RECURRENCE RISK; RISK ASSESSMENT; SHEEP ERYTHROCYTE; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG ADULT; ANIMAL; BINDING COMPETITION; CELL MEMBRANE; CYTOLOGY; ERYTHROCYTE; GENETICS; HEMOLYSIS; KIDNEY DISEASE; METABOLISM; SHEEP;

ANIMALS; ATYPICAL HEMOLYTIC UREMIC SYNDROME; BINDING, COMPETITIVE; CELL MEMBRANE; COMPLEMENT C3B INACTIVATOR PROTEINS; COMPLEMENT FACTOR H; COMPLEMENT SYSTEM PROTEINS; ERYTHROCYTES; EXONS; FEMALE; HEMOLYSIS; HETEROZYGOTE; HUMANS; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; MUTANT CHIMERIC PROTEINS; PEDIGREE; SHEEP;

EID: 84924196365     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013121339     Document Type: Article

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