Investigation of solubilising effects of bile salts on an active pharmaceutical ingredient with unusual pH dependent solubility by NMR spectroscopy

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 92, Issue , 2015, Pages 32-41

  Vogtherr, M ^a   Marx, A ^a   Mieden, A C ^a   Saal, C ^a  

^a MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; AMINO ACID DERIVATIVE; AMPHOPHILE; BENZYL DERIVATIVE; BILE SALT; PHOSPHATIDYLCHOLINE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; [METHYL [3 [5 (2 METHYL 2 TRIFLUOROMETHYL BIPHENYL 4 YL) [1,2,4]OXADIAZOL 3 YL]BENZYL]AMINO]ACETIC ACID; BILE ACID; DRUG; MICELLE;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG SOLUBILITY; FASTED STATE SIMULATED INTESTINAL FLUID; GEOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE FLUID; IONIC STRENGTH; LIPOPHILICITY; MICELLE; MICELLIZATION; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PH; POTENTIOMETRIC TITRATION; PRECIPITATION; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; TITRIMETRY; X RAY POWDER DIFFRACTION; CHEMISTRY; COMPARATIVE STUDY; INTESTINAL SECRETIONS; MEDICINAL CHEMISTRY; METABOLISM; PROCEDURES; SOLUBILITY;

BILE ACIDS AND SALTS; CHEMISTRY, PHARMACEUTICAL; HYDROGEN-ION CONCENTRATION; INTESTINAL SECRETIONS; LECITHINS; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; TAUROCHOLIC ACID;

EID: 84924174053     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.02.016     Document Type: Article

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