Glycosphingolipids are required for sorting melanosomal proteins in the Golgi complex

Journal of Cell Biology

Volumn 155, Issue 4, 2001, Pages 369-379

  Sprong, Hein ^a,b   Degroote, Sophie ^a   Claessens, Tijs ^b   Van Drunen, Judith ^b   Oorschot, Viola ^b,c   Westerink, Ben H C ^d   Hirabayashi, Yoshio ^e   Klumperman, Judith ^b,c   Van Der Sluijs, Peter ^b   Van Meer, Gerrit ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b University Medical Center   (Netherlands)

^c Center for Biomedical Genetics   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Glycosphingolipid; Melanosome; Protein sorting; TRP 1; Tyrosinase

Indexed keywords

CELL PROTEIN; CERAMIDE GLUCOSYLTRANSFERASE; GLYCOSPHINGOLIPID; MELANIN; MONOPHENOL MONOOXYGENASE; PIGMENT; SPHINGOSINE DERIVATIVE; TYROSINASE RELATED PROTEIN 1; GLUCOSYLTRANSFERASE; LEVODOPA; MEMBRANE PROTEIN; OXIDOREDUCTASE; PROTEIN; PSYCHOSINE; SPHINGOSINE; SPHINGOSYL BETA-GLUCOSIDE; TUMOR PROTEIN; TYROSINASE-RELATED PROTEIN-1; TYRP1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL LINE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOSOME; ENZYME LOCALIZATION; GENETIC TRANSFECTION; GOLGI COMPLEX; LIPID TRANSPORT; MELANOGENESIS; MELANOMA CELL; MELANOSOME; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; PIGMENTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; PROTEIN TRANSPORT; ANALOGS AND DERIVATIVES; ANIMAL; BINDING SITE; BIOSYNTHESIS; BOVINAE; CELL VACUOLE; CHO CELL LINE; ENZYME ACTIVATION; GENETICS; HAMSTER; LYSOSOME; METABOLISM; TUMOR CELL CULTURE;

ANIMALIA;

ANIMALS; BINDING SITES; CATTLE; CELL MEMBRANE; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; GLUCOSYLTRANSFERASES; GLYCOSPHINGOLIPIDS; GOLGI APPARATUS; LEVODOPA; LYSOSOMES; MELANINS; MELANOSOMES; MEMBRANE GLYCOPROTEINS; MICE; MONOPHENOL MONOOXYGENASE; NEOPLASM PROTEINS; OXIDOREDUCTASES; PIGMENTATION; PROTEIN TRANSPORT; PROTEINS; PSYCHOSINE; SPHINGOSINE; TUMOR CELLS, CULTURED; VACUOLES;

EID: 84924148939     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. The identification of type 1 Gaucher disease patients, asymptomatic cases and carriers in the Netherlands using urine samples: An evaluation
2. Misrouting of tyrosinase with a truncated cytoplasmic tail as a result of the murine platinum (cp) mutation
3. Tyrosinase folding and copper loading in vivo: A crucial role for calnexin and alpha-glucosidase II
4. Structure and function of sphingolipid- and cholesterol-rich membrane rafts
5. Aliphatic and alicyclic diols induce melanogenesis in cultured cells and guinea pig skin
6. Topology of sphingolipid galactosyltransferases in ER and Golgi: Transbilayer movement of monohexosyl sphingolipids is required for higher glycosphingolipid biosynthesis
7. A cytoplasmic sequence in human tyrosinase defines a second class of di-leucine-based sorting signals for late endosomal and lysosomal delivery
8. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the β3A subunit of the AP-3 adaptor
9. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
10. The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopig mentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness
11. Ultraviolet radiation directly induces pigment production by cultured human melanocytes
12. New insights in glycosphingolipid function: "Glycosignaling domain," a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling
13. Proper folding and endoplasmic reticulum to Golgi transport of tyrosinase are induced by its substrates, DOPA and tyrosine
14. GSa stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A
15. TMBase - A database of membrane spanning protein segments
16. The organizing potential of sphingolipids in intracellular membrane transport
17. A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3
18. Ap-3 mediates tyrosinase but not trp-1 trafficking in human melanocytes
19. Selective inhibition of transcytosis by brefeldin A in MDCK cells
20. A mouse B16 melanoma mutant deficient in glycolipids
21. Golgi apparatus in chick skeletal muscle: Changes in its distribution during end plate development and after denervation
22. Biological role of tyrosinase related protein and its biosynthesis and transport from TGN to stage I melanosome, late endosome, through gene transfection study
23. Mammalian tyrosinase: Biosynthesis, processing, and modulation by melanocyte-stimulating hormone
24. Tyrosinase isoenzymes in mammalian melanocytes. 1. Biochemical characterization of two melanosomal tyrosinases from B16 mouse melanoma
25. Improved tyrosinase activity stains in polyacrylamide electrophoresis gels
26. Adaptors for clathrin-mediated traffic
27. Structure and function of the mannose 6-phosphate/insulin-like growth factor II receptors
28. The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins
29. Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts
30. Internalization and sorting of a fluorescent analogue of glucosylceramide to the Golgi apparatus of human skin fibroblasts: Utilization of endocytic and nonendocytic transport mechanisms
31. Transforming growth factor-β1 inhibits basal melanogenesis in B16/F10 mouse melanoma cells by increasing the rate of degradation of tyrosinase and tyrosinase-related protein-1
32. Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers
33. muIA-adaptin-deficient mice: Lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
34. Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention
35. An investigation of the role of transmembrane domains in Golgi protein retention
36. Protein specific N-glycosylation of tyrosinase and tyrosinase-related protein-1 in B16 mouse melanoma cells
37. Molecular basis of albinism: Mutations and polymorphisms of pigmentation genes associated with albinism
38. Glycosphingolipids are not essential for formation of detergent-resistant membrane rafts in melanoma cells. Methyl-beta-cyclodextrin does not affect cell surface transport of a GPI-anchored protein
39. Inhibition of N-glycan processing in B16 melanoma cells results in inactivation of tyrosinase but does not prevent its transport to the melanosome
40. Sorting of mannose 6-phosphate receptors mediated by the GGAs
41. Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells
42. Inhibition of glycoprotein traffic through the secretory pathway by ceramide
43. The tyrosinase tail mediates sorting to the lysosomal compartment in MDCK cells via a dileucine and a tyrosine-based signal
44. Lipid sorting in epithelial cells
45. Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa
46. Melanogenesis in cultured melanocytes can be substantially influenced by L-tyrosine and L-cysteine
47. UDP-galactose: Ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum
48. How proteins move lipids and lipids move proteins
49. Pigmentation-associated glycoprotein of human melanomas and melanocytes: Definition with a mouse monoclonal antibody
50. Sorting of newly synthesized galactosphingolipids to the two surface domains of epithelial cells
51. Synthesis of non-hydroxy-galactosylceramides and galactosyldiglycerides by hydroxy-ceramide galactosyltransferase
52. Differential targeting of glucosylceramide and galactosylceramide analogues after synthesis but not during transcytosis in Madin-Darby canine kidney cells
53. (Glyco)sphingolipids are sorted in sub-apical compartments in HepG2 cells: A role for non-Golgi-related intracellular sites in the polarized distribution of (glyco)sphingolipids
54. Intracellular sorting and targeting of melanosomal membrane proteins: Identification of signals for sorting of the human brown locus protein, gp75
55. Effects of drugs interfering with dopamine and noradrenaline biosynthesis on the endogenous 3,4-dihydroxyphenylalanine levels in rat brain
56. A vital role for glycosphingolipid synthesis during development and differentiation
57. Binding of gga2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor