HIV-1 replicates in human osteoclasts and enhances their differentiation in vitro

Retrovirology

Volumn 12, Issue 1, 2015, Pages

  Gohda, Jin ^a,b   Ma, Yijing ^a   Huang, Ying ^a   Zhang, Yu ^a   Gu, Lijun ^a,b   Han, Yang ^c   Li, Taisheng ^c   Gao, Bin ^a   Gao, Fu ^a   Inoue, Jun ichiro ^b   Iwamoto, Aikichi ^b   Ishida, Takaomi ^a,b  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF TOKYO   (Japan)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Bone disease; HIV 1; Iinfection; Macrophages; Osteoclasts

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CALCITONIN RECEPTOR; CATHEPSIN K; CD14 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; TENOFOVIR; CCR5 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN;

ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL NUCLEUS; CELL SIZE; CELL SURFACE; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; INFECTION SENSITIVITY; MACROPHAGE; MONOCYTE; MULTINUCLEAR CELL; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PROTEIN EXPRESSION; UPREGULATION; VIRUS INFECTION; VIRUS REPLICATION; CELL CULTURE; CHEMISTRY; PHYSIOLOGY; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIGENS, CD14; ANTIGENS, CD4; CELL DIFFERENTIATION; CELLS, CULTURED; HIV-1; HUMANS; OSTEOCLASTS; RECEPTORS, CCR5; RECEPTORS, CXCR4; VIRUS REPLICATION;

EID: 84924104455     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/s12977-015-0139-7     Document Type: Article

References (23)

1. Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med. 2005;352:48-62.
2. El-Sadr WM, Lundgren J, Neaton JD, Gordin F, Abrams D, Arduino RC, et al. CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med. 2006;355:2283-96.
3. Brown TT, Qaqish RB. Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review. AIDS. 2006;20:2165-74.
4. Glesby MJ. Bone disorders in human immunodeficiency virus infection. Clin Infect Dis. 2003;37:91-6.
5. Gibellini D, Borderi M, De Crignis E, Cicola R, Vescini F, Caudarella R, et al. RANKL/OPG/TRAIL plasma levels and bone mass loss evaluation in antiretroviral naïve HIV-1-positive men. J Med Virol. 2007;79:1446-54.
6. Nakashima T, Hayashi M, Takayanagi H. New insights into osteoclastogenic signaling mechanisms. Trends Endocrinol Metab. 2012;23:582-90.
7. Zhao R. Immune regulation of osteoclast function in postmenopausal osteoporosis: a critical interdisciplinary perspective. Int J Med Sci. 2012;9:825-32.
8. Vikulina T, Fan X, Yamaguchi M, Roser-Page S, Zayzafoon M, Guidot DM, et al. Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats. Proc Natl Acad Sci U S A. 2010;107:13848-53.
9. Take I, Kobayashi Y, Yamamoto Y, Tsuboi H, Ochi T, Uematsu S, et al. Prostaglandin E2 strongly inhibits human osteoclast formation. Endocrinology. 2005;146:5204-14.
10. Minkin C. Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif Tissue Int. 1982;34:285-90.
11. Faust J, Lacey DL, Hunt P, Burgess TL, Scully S, Van G, et al. Osteoclast markers accumulate on the cells developing from human peripheral blood mononuclear precursors. J Cell Biochem. 1999;72:67-80.
12. Valentin A, Trivedi H, Lu W, Kostrikis LG, Pavlakis GN. CXCR4 mediates entry and productive infection of syncytia-inducing (X4) HIV-1 strains in primary macrophages. Virology. 2000;269:294-304.
13. Alexaki A, Liu Y, Wigdahl B. Cellular reservoirs of HIV-1 and their role in viral persistence. Curr HIV Res. 2008;6:388-400.
14. Haskelberg H, Carr A, Emery S. Bone turnover markers in HIV disease. AIDS Rev. 2011;13:240-50.
15. Costa AG, Cusano NE, Silva BC, Cremers S, Bilezikian JP. Cathepsin K: its skeletal actions and roles as a therapeutic target in osteoporosis. Nat Rev Rheumatol. 2011;7:447-56.
16. Pondel M. Calcitonin and calcitonin receptors: bone and beyond. Int J Exp Pathol. 2000;81:405-22.
17. Gibellini D, De Crignis E, Ponti C, Borderi M, Clo A, Miserocchi A, et al. HIV-1 Tat protein enhances RANKL/M-CSF-mediated osteoclast differentiation. Biochem Biophys Res Commun. 2010;401:429-34.
18. Zupan J, Jeras M, Marc J. Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts. Biochem Med. 2013;23:43-63.
19. Abramoff MD, Magelhaes PJ, Ram SJ. Image processing with ImageJ. Biophotonics Int. 2004;11:36-42.
20. Koyanagi Y, Miles S, Mitsuyasu RT, Merrill JE, Vinters HV, Chen IS. Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science. 1987;236:819-22.
21. Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A, et al. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol. 1986;59:284-91.
22. Hachiya A, Aizawa-Matsuoka S, Tanaka M, Takahashi Y, Ida S, Gatanaga H, et al. Rapid and simple phenotypic assay for drug susceptibility of human immunodeficiency virus type 1 using CCR5-expressing HeLa/CD4(+) cell clone 1-10 (MAGIC-5). Antimicrob Agents Chemother. 2001;45:495-501.
23. Álvarez-Fernández C, Crespo Guardo A, García-Pérez J, García F, Blanco J, Escribà-García L, et al. Generation and characterization of a defective HIV-1 Virus as an immunogen for a therapeutic vaccine. PLoS One. 2012;7:e48848.