CD8+ T Lymphocyte Expansion, Proliferation and Activation in Dengue Fever

PLoS Neglected Tropical Diseases

Volumn 9, Issue 2, 2015, Pages

  de Matos, Andréia Manso ^a   Carvalho, Karina Inacio ^a,b   Rosa, Daniela Santoro ^a,c   Villas Boas, Lucy Santos ^a   da Silva, Wanessa Cardoso ^a   Rodrigues, Célia Luiza de Lima ^a   Oliveira, Olímpia Massae Nakasone Peel Furtado ^d   Levi, José Eduardo ^a   Araújo, Evaldo Stanislau Affonso ^a,d   Pannuti, Claudio Sergio ^a   Luna, Expedito José Albuquerque ^a   Kallas, Esper George ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d HOSPITAL ANA COSTA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; KI 67 ANTIGEN; CD38 PROTEIN, HUMAN; MEMBRANE PROTEIN; VIRUS ANTIBODY;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL EXPANSION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENGUE; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNE RESPONSE; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEROLOGY; VERY ELDERLY; VIRUS LOAD; YOUNG ADULT; BLOOD; BRAZIL; CLASSIFICATION; DENGUE VIRUS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MONONUCLEAR CELL; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTIBODIES, VIRAL; ANTIGENS, CD38; BRAZIL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DENGUE; DENGUE VIRUS; FEMALE; FLOW CYTOMETRY; HLA-DR ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; KI-67 ANTIGEN; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 84924082739     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003520     Document Type: Article

References (39)

1. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, et al. (2013) The global distribution and burden of dengue. Nature 496: 504–507. doi: 10.1038/nature12060 23563266
2. PAHO (2008) Number of Reported Cases of Dengue and Dengue Hemorrhagic Fever (DHF), Region of the Americas (by country and subregion). Pan American Health Society.
3. Messer W, Vitarana U, Sivananthan K, Elvtigala J, Preethimala L, et al. (2002) Epidemiology of dengue in Sri Lanka before and after the emergence of epidemic dengue hemorrhagic fever. Am J Trop Med Hyg 66: 765–773. 12224589
4. Malavige G, Fernando S, Fernando D, Seneviratne S, (2004) Dengue viral infections. Postgrad Med J 80: 588–601. 15466994
5. Halstead S, (1988) Pathogenesis of dengue: challenges to molecular biology. Science 239: 476–481. 3277268
6. Halstead S, (2007) Dengue. Lancet 370: 1644–1652. 17993365
7. Endy T, Nisalak A, Chunsuttitwat S, Vaughn D, Green S, et al. (2004) Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand. J Infect Dis 189: 990–1000. 14999601
8. Schmid ML, McKendrick MW, Green ST, Ridgway EJ, (1999) More financial resources must be provided for multidrug resistant TB. BMJ 318: 1076. 10205123
9. Mathew A, Kurane I, Green S, Vaughn DW, Kalayanarooj S, et al. (1999) Impaired T cell proliferation in acute dengue infection. J Immunol 162: 5609–5615. 10228044
10. McMichael AJ, Ogg G, Wilson J, Callan M, Hambleton S, et al. (2000) Memory CD8+ T cells in HIV infection. Philos Trans R Soc Lond B Biol Sci 355: 363–367. 10794056
11. Appay V, van Lier RA, Sallusto F, Roederer M, (2008) Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 73: 975–983. doi: 10.1002/cyto.a.20643 18785267
12. Romano CM, de Matos AM, Araujo ES, Villas-Boas LS, da Silva WC, et al. (2010) Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic. PLoS One 5: e11811. doi: 10.1371/journal.pone.0011811 20676363
13. de Souza VA, Fernandes S, Araujo ES, Tateno AF, Oliveira OM, et al. (2004) Use of an immunoglobulin G avidity test to discriminate between primary and secondary dengue virus infections. J Clin Microbiol 42: 1782–1784. 15071049
14. Lai YL, Chung YK, Tan HC, Yap HF, Yap G, et al. (2007) Cost-effective real-time reverse transcriptase PCR (RT-PCR) to screen for Dengue virus followed by rapid single-tube multiplex RT-PCR for serotyping of the virus. J Clin Microbiol 45: 935–941. 17215345
15. Levi JE, Tateno AF, Machado AF, Ramalho DC, de Souza VA, et al. (2007) Evaluation of a commercial real-time PCR kit for detection of dengue virus in samples collected during an outbreak in Goiania, Central Brazil, in 2005. J Clin Microbiol 45: 1893–1897. 17409201
16. Goncalves RM, Salmazi KC, Santos BA, Bastos MS, Rocha SC, et al. (2010) CD4+ CD25+ Foxp3+ regulatory T cells, dendritic cells, and circulating cytokines in uncomplicated malaria: do different parasite species elicit similar host responses? Infect Immun 78: 4763–4772. doi: 10.1128/IAI.00578-10 20713627
17. Roederer M, (2001) Spectral compensation for flow cytometry: visualization artifacts, limitations, and caveats. Cytometry 45: 194–205. 11746088
18. Sarasombath S, Suvatte V, Homchampa P, (1988) Kinetics of lymphocyte subpopulations in dengue hemorrhagic fever/dengue shock syndrome. Southeast Asian J Trop Med Public Health 19: 649–656. 3238478
19. Liu CC, Huang KJ, Lin YS, Yeh TM, Liu HS, et al. (2002) Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection. J Med Virol 68: 241–252. 12210415
20. Azeredo EL, Zagne SM, Alvarenga AR, Nogueira RM, Kubelka CF, et al. (2006) Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease. Mem Inst Oswaldo Cruz 101: 437–449. 16951817
21. Durbin AP, Vargas MJ, Wanionek K, Hammond SN, Gordon A, et al. (2008) Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever. Virology 376: 429–435. doi: 10.1016/j.virol.2008.03.028 18452966
22. Corley RB, LoCascio NJ, Ovnic M, Haughton G, (1985) Two separate functions of class II (Ia) molecules: T-cell stimulation and B-cell excitation. Proc Natl Acad Sci U S A 82: 516–520. 3155862
23. Chau TN, Quyen NT, Thuy TT, Tuan NM, Hoang DM, et al. (2008) Dengue in Vietnamese infants—results of infection-enhancement assays correlate with age-related disease epidemiology, and cellular immune responses correlate with disease severity. J Infect Dis 198: 516–524. doi: 10.1086/590117 18598189
24. Dung NT, Duyen HT, Thuy NT, Ngoc TV, Chau NV, et al. (2010) Timing of CD8+ T cell responses in relation to commencement of capillary leakage in children with dengue. J Immunol 184: 7281–7287. doi: 10.4049/jimmunol.0903262 20483770
25. Mathew A, Rothman AL, (2008) Understanding the contribution of cellular immunity to dengue disease pathogenesis. Immunol Rev 225: 300–313. doi: 10.1111/j.1600-065X.2008.00678.x 18837790
26. Green S, Pichyangkul S, Vaughn DW, Kalayanarooj S, Nimmannitya S, et al. (1999) Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. J Infect Dis 180: 1429–1435. 10515800
27. Zielinski CE, Corti D, Mele F, Pinto D, Lanzavecchia A, et al. (2011) Dissecting the human immunologic memory for pathogens. Immunol Rev 240: 40–51. doi: 10.1111/j.1600-065X.2010.01000.x 21349085
28. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A, (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708–712. 10537110
29. Geginat J, Lanzavecchia A, Sallusto F, (2003) Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood 101: 4260–4266. 12576317
30. Tomiyama H, Matsuda T, Takiguchi M, (2002) Differentiation of human CD8(+) T cells from a memory to memory/effector phenotype. J Immunol 168: 5538–5550. 12023349
31. Lanzavecchia A, Sallusto F, (2005) Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 17: 326–332. 15886125
32. Weiskopf D, Angelo MA, de Azeredo EL, Sidney J, Greenbaum JA, et al. (2013) Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells. Proc Natl Acad Sci U S A 110: E2046–2053. doi: 10.1073/pnas.1305227110 23580623
33. Guidotti LG, Chisari FV, (2001) Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 19: 65–91. 11244031
34. Bashyam HS, Green S, Rothman AL, (2006) Dengue virus-reactive CD8+ T cells display quantitative and qualitative differences in their response to variant epitopes of heterologous viral serotypes. J Immunol 176: 2817–2824. 16493038
35. Friberg H, Burns L, Woda M, Kalayanarooj S, Endy TP, et al. (2011) Memory CD8+ T cells from naturally acquired primary dengue virus infection are highly cross-reactive. Immunol Cell Biol 89: 122–129. doi: 10.1038/icb.2010.61 20421879
36. Guirakhoo F, Arroyo J, Pugachev KV, Miller C, Zhang ZX, et al. (2001) Construction, safety, and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine. J Virol 75: 7290–7304. 11462001
37. Capeding MR, Tran NH, Hadinegoro SR, Ismail HI, Chotpitayasunondh T, et al. (2014) Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial. Lancet 384: 1358–1365. doi: 10.1016/S0140-6736(14)61060-6 25018116
38. Villar L, Dayan GH, Arredondo-Garcia JL, Rivera DM, Cunha R, et al. (2014) Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America. N Engl J Med. doi: 10.1056/NEJMsr1414226 25548814
39. Weiskopf D, Angelo MA, Bangs DJ, Sidney J, Paul S, et al. (2015) The Human CD8+ T Cell Responses Induced by a Live Attenuated Tetravalent Dengue Vaccine Are Directed against Highly Conserved Epitopes. Journal of virology 89: 120–128. doi: 10.1128/JVI.02129-14 25320311