In vitro profiling of the metabolism and drug-drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP

Xenobiotica

Volumn 45, Issue 3, 2015, Pages 230-238

  Yamane, Mizuki ^a   Kawashima, Kosuke ^a   Yamaguchi, Koji ^a   Nagao, Shunsuke ^a   Sato, Mika ^a   Suzuki, Masayuki ^a   Honda, Kiyofumi ^a   Hagita, Hitoshi ^b   Kuhlmann, Olaf ^c   Poirier, Agnes ^c   Fowler, Stephen ^c   Funk, Christoph ^c   Simon, Sandrine ^c   Aso, Yoshinori ^a   Ikeda, Sachiya ^a   Ishigai, Masaki ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b Chugai Research Institute for Medical Science Inc   (Japan)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

CYP; Diabetes mellitus; Induction; Inhibition; Metabolism; SGLT2

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C18; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3FB; CYTOCHROME P450 4A11; CYTOCHROME P450 4F2; TOFOGLIFLOZIN; UNCLASSIFIED DRUG; 6-((4-ETHYLPHENYL)METHYL)-3',4',5',6'-TETRAHYDRO-6'-(HYDROXYMETHYL)SPIRO(ISOBENZOFURAN-1(3H),2'-(2H)PYRAN)-3',4',5'-TRIOL; BENZHYDRYL DERIVATIVE; CARBON; COENZYME; CYTOCHROME P450 INHIBITOR; GLUCOSIDE; PROTEIN BINDING; RECOMBINANT PROTEIN; SODIUM GLUCOSE COTRANSPORTER 2;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; PROTEIN BINDING; TANDEM MASS SPECTROMETRY; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; COENZYME; DRUG EFFECTS; DRUG INTERACTION; ENZYME INDUCTION; ENZYMOLOGY; IC50; METABOLISM; METABOLOME; METABOLOMICS; PROCEDURES; TIME;

BENZHYDRYL COMPOUNDS; CARBON RADIOISOTOPES; COENZYMES; CYTOCHROME P-450 ENZYME INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME INDUCTION; GLUCOSIDES; HEPATOCYTES; HUMANS; INHIBITORY CONCENTRATION 50; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; METABOLOMICS; MICROSOMES, LIVER; PROTEIN BINDING; RECOMBINANT PROTEINS; SODIUM-GLUCOSE TRANSPORTER 2; TIME FACTORS;

EID: 84924076457     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2014.976296     Document Type: Article

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