Candidaemia in a paediatric centre and importance of central venous catheter removal

Mycoses

Volumn 58, Issue 3, 2015, Pages 140-148

  Karadag Oncel, Eda ^a   Kara, Ates ^a   Ozsurekci, Yasemin ^a   Arikan Akdagli, Sevtap ^a   Cengiz, Ali Bulent ^a   Ceyhan, Mehmet ^a   Gur, Deniz ^a   Celik, Melda ^a   Ozkaya Parlakay, Aslinur ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Candidaemia; Central venous catheter; Children; Mortality; Risk factors

Indexed keywords

AMPHOTERICIN B; CASPOFUNGIN; FLUCONAZOLE; VORICONAZOLE; ANTIFUNGAL AGENT;

ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; ARTIFICIAL VENTILATION; CANDIDA; CANDIDA ALBICANS; CANDIDA FAMATA; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA SAKE; CANDIDA TROPICALIS; CANDIDEMIA; CATHETER REMOVAL; CENTRAL VENOUS CATHETER; CHILD; CHILDHOOD DISEASE; FEMALE; GENDER; HOSPITAL ADMISSION; HUMAN; HYPOALBUMINEMIA; HYPOPHOSPHATEMIA; IMMUNOSUPPRESSIVE TREATMENT; KLUYVEROMYCES MARXIANUS; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; NEUTROPHIL COUNT; PATIENT HISTORY OF SURGERY; PEDIATRIC HOSPITAL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SPECIES; SPECIES DISTRIBUTION; SURGICAL WARD; SURVIVAL RATE; THROMBOCYTE COUNT; THROMBOCYTOPENIA; YARROWIA LIPOLYTICA; CANDIDIASIS; CLASSIFICATION; CROSS INFECTION; INFANT; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MORTALITY; MULTIDRUG RESISTANCE; PRESCHOOL CHILD;

CANDIDA; CANDIDA ALBICANS; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS;

ANTIFUNGAL AGENTS; CANDIDA; CANDIDA ALBICANS; CANDIDA TROPICALIS; CANDIDEMIA; CANDIDIASIS; CENTRAL VENOUS CATHETERS; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, FUNGAL; FEMALE; HUMANS; INFANT; MALE; MICROBIAL SENSITIVITY TESTS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84924018096     PISSN: 09337407     EISSN: 14390507     Source Type: Journal    
DOI: 10.1111/myc.12288     Document Type: Article

References (30)

1. Maródi L, Johnston RB, Jr. Invasive Candida species disease in infants and children: occurrence, risk factors, management, and innate host defense mechanisms. Curr Opin Pediatr 2007; 19: 693-7.
2. Zaoutis TE, Prasad PA, Localio AR et al. Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications for prevention. Clin Infect Dis 2010; 51: 38-45.
3. Oeser C, Lamagni T, Heath PT, Sharland M, Ladhani S. The epidemiology of neonatal and pediatric candidemia in England and Wales, 2000-2009. Pediatr Infect Dis J 2013; 32: 23-26.
4. Cisterna R, Ezpeleta G, Telleria O; Spanish Candidemia Surveillance Group. Nationwide sentinel surveillance of bloodstream Candida infections in 40 tertiary care hospitals in Spain. J Clin Microbiol 2010; 48: 4200-6.
5. Pappas PG, Rex JH, Lee J; NIAID Mycoses Study Group et al. A prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients. Clin Infect Dis 2003; 37: 634-43.
6. Garey KW, Rege M, Pai MP et al. Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study. Clin Infect Dis 2006; 43: 25-31.
7. Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother 2005; 49: 3640-5.
8. Arendrup MC. Epidemiology of invasive candidiasis. Curr Opin Crit Care 2010; 16: 445-52.
9. Kojic EM, Darouiche RO. Candida infections of medical devices. Clin Microbiol Rev 2004; 17: 255-67.
10. Zaoutis TE, Greves HM, Lautenbach E, Bilker WB, Coffin SE. Risk factors for disseminated candidiasis in children with candidemia. Pediatr Infect Dis J 2004; 23: 635-41.
11. Larone DH. Medically Important Fungi: A Guide to Identification. Washington, DC: ASM Press, 2011.
12. Roilides E, Farmaki E, Evdoridou J et al. Neonatal candidiasis: analysis of epidemiology, drug susceptibility, and molecular typing of causative isolates. Eur J Clin Microbiol Infect Dis 2004; 23: 745-50.
13. Conde-Rosa A, Amador R, Pérez-Torres D et al. Candidemia distribution, associated risk factors, and attributed mortality at a university-based medical center. P R Health Sci J 2010; 29: 26-29.
14. Kibbler CC, Seaton S, Barnes RA et al. Management and outcome of bloodstream infections due to Candida species in England and Wales. J Hosp Infect 2003; 54: 18-24.
15. Zaoutis TE, Argon J, Chu J, Berlin JA, Walsh TJ, Feudtner C. The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis. Clin Infect Dis 2005; 41: 1232-9.
16. Lamagni TL, Evans BG, Shigematsu M, Johnson EM. Emerging trends in the epidemiology of invasive mycoses in England and Wales (1990-9). Epidemiol Infect 2001; 126: 397-414.
17. Tortorano AM, Peman J, Bernhardt H; ECMM Working Group on Candidaemia et al. Epidemiology of candidaemia in Europe: results of 28-month European Confederation of Medical Mycology (ECMM) hospital-based surveillance study. Eur J Clin Microbiol Infect Dis 2004; 23: 317-22.
18. Messer SA, Jones RN, Fritsche TR. International surveillance of Candida spp. and Aspergillus spp.: report from the SENTRY Antimicrobial Surveillance Program (2003). J Clin Microbiol 2006; 44: 1782-7.
19. Blyth CC, Chen SC, Slavin MA; Australian Candidemia Study et al. Not just little adults: candidemia epidemiology, molecular characterization, and antifungal susceptibility in neonatal and pediatric patients. Pediatrics 2009; 123: 1360-8.
20. Pfaller MA, Messer SA, Moet GJ, Jones RN, Castanheira M. Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in intensive care unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008-2009). Int J Antimicrob Agents 2011; 38: 65-69.
21. Awasthi AK, Jain A, Awasthi S, Ambast A, Singh K, Mishra V. Epidemiology and microbiology of nosocomial pediatric candidemia at a northern Indian tertiary care hospital. Mycopathologia 2011; 172: 269-77.
22. Hajjeh RA, Sofair AN, Harrison LH et al. Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program. J Clin Microbiol 2004; 42: 1519-27.
23. Lockhart SR, Iqbal N, Cleveland AA et al. Species identification and antifungal susceptibility testing of Candida bloodstream isolates from population-based surveillance studies in two U.S. cities from 2008 to 2011. J Clin Microbiol 2012; 50: 3435-42.
24. Lortholary O, Desnos-Ollivier M, Sitbon K, Fontanet A, Bretagne S, Dromer F; French Mycosis Study Group. Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: a prospective multicenter study involving 2, 441 patients. Antimicrob Agents Chemother 2011; 55: 532-8.
25. Dutta A, Palazzi DL. Candida non-albicans versus Candida albicans fungemia in the non-neonatal pediatric population. Pediatr Infect Dis J 2011; 30: 664-8.
26. Celebi S, Hacimustafaoglu M, Ozdemir O, Ozkaya G. Nosocomial candidaemia in children: results of a 9-year study. Mycoses 2008; 51: 248-57.
27. Brissaud O, Guichoux J, Harambat J, Tandonnet O, Zaoutis T. Invasive fungal disease in PICU: epidemiology and risk factors. Ann Intensive Care 2012; 2: 6.
28. Pappas PG, Kauffman CA, Andes D et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 48: 503-35.
29. Nucci M, Anaissie E, Betts RF et al. Early removal of central venous catheter in patients with candidemia does not improve outcome: analysis of 842 patients from 2 randomized clinical trials. Clin Infect Dis 2010; 51: 295-303.
30. Zhang XB, Yu SJ, Yu JX, Gong YL, Feng W, Sun FJ. Retrospective analysis of epidemiology and prognostic factors for candidemia at a hospital in China, 2000-2009. Jpn J Infect Dis 2012; 65: 510-15.