RhBSSL improves growth and LCPUFA absorption in preterm infants fed formula or pasteurized breast milk

Journal of Pediatric Gastroenterology and Nutrition

Volumn 59, Issue 1, 2014, Pages 61-69

  Casper, Charlotte ^a   Carnielli, Virgilio P ^b   Michel Hascoet, Jean ^c   Lapillonne, Alexandre ^d   Maggio, Luca ^e   Timdahl, Kristina ^f   Olsson, Birgitta ^f   Vagerö, Marten ^f   Hernell, Olle ^g  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c UNIVERSITÉ DE LORRAINE   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^e CATHOLIC UNIVERSITY   (Italy)

^f BIOVITRUM AB   (Sweden)

^g UMEÅ UNIVERSITY   (Sweden)

Author keywords

Clinical study; Fat absorption; Growth velocity; Preterm infant; Recombinant human bile salt stimulated lipase

Indexed keywords

ARACHIDONIC ACID; BUCELIPASE ALFA; DOCOSAHEXAENOIC ACID; LONG CHAIN FATTY ACID; POLYUNSATURATED FATTY ACID; BILE SALT-STIMULATED LIPASE; CHOLESTEROL ESTERASE; RECOMBINANT PROTEIN;

ARTICLE; ARTIFICIAL MILK; BODY WEIGHT; BREAST MILK; CHILD GROWTH; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FAT INTAKE; FEMALE; GESTATIONAL AGE; GROWTH RATE; HUMAN; INFANT; INFANT FEEDING; LIPID ABSORPTION; MAJOR CLINICAL STUDY; MALE; MENINGITIS; META ANALYSIS; NECROTIZING ENTEROCOLITIS; PASTEURIZATION; PHASE 2 CLINICAL TRIAL; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEPTIC SHOCK; ULCERATIVE COLITIS; ADMINISTRATION AND DOSAGE; CHILD DEVELOPMENT; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; INTESTINE ABSORPTION; NEWBORN; VERY LOW BIRTH WEIGHT;

ARACHIDONIC ACID; CHILD DEVELOPMENT; CROSS-OVER STUDIES; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; INFANT FORMULA; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, VERY LOW BIRTH WEIGHT; INTESTINAL ABSORPTION; MALE; MILK, HUMAN; PASTEURIZATION; RECOMBINANT PROTEINS; STEROL ESTERASE;

EID: 84923912959     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000365     Document Type: Article

References (41)

1. Ehrenkranz RA, Dusick AM, Vohr BR, et al. Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infants. Pediatrics 2006;117:1253-61.
2. De Curtis M, Rigo J. The nutrition of preterm infants. Early Hum Dev 2012;88 (suppl 1):S5-7.
3. Lapillonne A, Griffin IJ. Feeding preterm infants today for later metabolic and cardiovascular outcomes. J Pediatr 2013;162 (3 suppl): S7-16.
4. Pilling EL, Elder CJ, Gibson AT. Growth patterns in the growth-retarded premature infant. Best Pract Res Clin Endocrinol Metab 2008;22:447-62.
5. Clark RH, Thomas P, Peabody J. Extrauterine growth restriction remains a serious problem in prematurely born neonates. Pediatrics 2003;111 (5 pt 1):986-90.
6. Corpeleijn WE, Vermeulen MJ, van den Akker CH, et al. Feeding verylow-birth-weight infants: our aspirations versus the reality in practice. Ann Nutr Metab 2011;58 (suppl 1):20-9.
7. Ye G, Jiang Z, Lu S, et al. Premature infants born after preterm premature rupture of membranes with 24-34 weeks of gestation: a study of factors influencing length of neonatal intensive care unit stay. J Matern Fetal Neonatal Med 2011;24:960-5.
8. Merritt TA, Pillers D, Prows SL. Early NICU discharge of very low birth weight infants: a critical review and analysis. Semin Neonatol 2003;8:95-115.
9. Ehrenkranz RA, Younes N, Lemons JA, et al. Longitudinal growth of hospitalized very low birth weight infants. Pediatrics 1999;104 (2 pt 1):280-9.
10. Riddle WR, DonLevy SC. Defining the expected growth of the preterm infant. In: Preedy VR, ed. Handbook of Growth and Growth Monitoring in Health and Disease. Vol 1. New York: Springer; 2012:625-41.
11. Ruth VA. Extrauterine growth restriction: a review of the literature. Neonatal Netw 2008;27:177-84.
12. Embleton NE, Pang N, Cooke RJ. Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants? Pediatrics 2001;107:270-3.
13. Gould JF, Smithers LG, Makrides M. The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 2013;97:531-44.
14. Innis SM. Fatty acids and early human development. Early Hum Dev 2007;83:761-6.
15. Georgieff MK, Innis SM. Controversial nutrients that potentially affect preterm neurodevelopment: essential fatty acids and iron. Pediatr Res 2005;57 (5 pt 2):99R-103R.
16. Lapillonne A, Groh-Wargo S, Gonzalez CH, et al. Lipid needs of preterminfants: updated recommendations. J Pediatr 2013;162 (3 suppl): S37-47.
17. Björkstén B, Burman LG, De Chateau P, et al. Collecting and banking human milk: to heat or not to heat? Br Med J 1980;281:765-9.
18. Andersson Y, Sävman K, Bläckberg L, et al. Pasteurization of mother's own milk reduces fat absorption and growth in preterm infants. Acta Paediatr 2007;96:1445-9.
19. Lindquist S, Andersson EL, Lundberg L, et al. Bile salt-stimulated lipase plays an unexpected role in arthritis development in rodents. PLoS One 2012;7:e47006.
20. Andersson EL, Hernell O, Bläckberg L, et al. BSSL and PLRP2: key enzymes for lipid digestion in the newborn examined using the Caco-2 cell line. J Lipid Res 2011;52:1949-56.
21. Lindquist S, Hernell O. Lipid digestion and absorption in early life: an update. Curr Opin Clin Nutr Metab Care 2010;13:314-20.
22. Hernell O, Bläckberg L. Digestion of human milk lipids: physiologic significance of sn-2 monoacylglycerol hydrolysis by bile salt-stimulated lipase. Pediatr Res 1982;16:882-5.
23. Lebenthal E, Lee PC. Development of functional responses in human exocrine pancreas. Pediatrics 1980;66:556-60.
24. Bernbäck S, Bläckberg L, Hernell O. The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipasedependent lipase, and bile salt-stimulated lipase. Clin Invest 1990;85: 1221-6.
25. Montjaux-Régis N, Cristini C, Arnaud C, et al. Improved growth of preterm infants receiving mother's own raw milk compared with pasteurized donor milk. Acta Paediatr 2011;100:1548-54.
26. The Early Nutrition Programming Project (EARNEST). Theme 6. www.metabolic-programming.org/theme6.htm. Accessed May 28, 2014.
27. Strömqvist M, Hernell O, Hansson L, et al. Naturally occurring variants of human milk bile salt-stimulated lipase. Arch Biochem Biophys 1997;347:30-6.
28. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
29. Chen Q, Bläckberg L, Nilsson A, et al. Digestion of triacylglycerols containing long-chain polyenoic fatty acids in vitro by colipase-dependent pancreatic lipase and human milk bile salt-stimulated lipase. Biochim Biophys Acta 1994;1210:239-43.
30. Howles PN, Stemmerman GN, Fenoglio-Preiser CM, et al. Carboxyl ester lipase activity in milk prevents fat-derived intestinal injury in neonatal mice. Am J Physiol 1999;277:G653-61.
31. Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: commentary from the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010;50:85-91.
32. Lin YH, Llanos A, Mena P, et al. Compartmental analyses of 2H5-alphalinolenic acid and C-U-eicosapentaenoic acid toward synthesis of plasma labeled 22:6n-3 in newborn term infants. Am J Clin Nutr 2010;92:284-93.
33. Carnielli VP, Simonato M, Verlato G, et al. Synthesis of long-chain polyunsaturated fatty acids in preterm newborns fed formula with longchain polyunsaturated fatty acids. Am J Clin Nutr 2007;86:1323-30.
34. Koletzko B, Agostoni C, Bergmann R, et al. Physiological aspects of human milk lipids and implications for infant feeding: a workshop report. Acta Paediatr 2011;100:1405-15.
35. Calder PC, Dangour AD, Diekman C, et al. Essential fats for future health. Proceedings of the 9th Unilever Nutrition Symposium, 26-27 May 2010. Eur J Clin Nutr 2010;64(Suppl 4):S1-3.
36. Innis SM. Dietary omega 3 fatty acids and the developing brain. Brain Res 2008;1237:35-43.
37. Larque E, Demmelmair H, Koletzko B. Perinatal supply and metabolism of long-chain polyunsaturated fatty acids: importance for the early development of the nervous system. Ann N Y Acad Sci 2002;967:299-310.
38. Escolano-Margarit MV, Ramos R, Beyer J, et al. Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated. J Nutr 2011;141:1216-23.
39. Hernell O. Assessing fat absorption. J Pediatr 1999;135:407-9.
40. Bläckberg L, Hernell O. Bile salt-stimulated lipase in human milk. Evidence that bile salt induces lipid binding and activation via binding to different sites. FEBS Lett 1993;323:207-10.
41. Ehrenkranz RA. Early nutritional support and outcomes in ELBW infants. Early Hum Dev 2010;86(Suppl 1):21-5.