Early changes of the kinetics of monocyte trem-1 reflect final outcome in human sepsis

BMC Immunology

Volumn 15, Issue 1, 2014, Pages

  Marioli, Androniki ^a   Koupetori, Marina ^b   Raftogiannis, Maria ^c   Patrani, Maria ^d   Antonakos, Nikolaos ^c   Pavlaki, Maria ^e   Adamis, Georgios ^f   Dougekou, Georgia ^c   Damoraki, Georgia ^c   Tsangaris, Iraklis ^g  

^a SISMANOGLIO HOSPITAL   (Greece)

^b THRIASIO GENERAL HOSPITAL   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^d Intensive Care Unit   (Greece)

^e Argos Periferiakos Koklas   (Greece)

^f G GENNIMATAS GENERAL HOSPITAL   (Greece)

^g NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Monocytes; Outcome; Sepsis; sTREM 1; TREM 1

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE GENE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; OBSERVATIONAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; REAL TIME POLYMERASE CHAIN REACTION; SEPSIS; SEPTIC SHOCK; SERUM; SEVERE SEPSIS; SURVIVAL RATE; SURVIVOR; TREATMENT OUTCOME; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1 GENE; BLOOD; CLINICAL TRIAL; DISEASE FREE SURVIVAL; FOLLOW UP; GENE EXPRESSION REGULATION; IMMUNOLOGY; KINETICS; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; VERY ELDERLY;

IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM1 PROTEIN, HUMAN;

AGED; AGED, 80 AND OVER; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION; HUMANS; KINETICS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MONOCYTES; RECEPTORS, IMMUNOLOGIC; SEPSIS; SURVIVAL RATE;

EID: 84923911742     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/s12865-014-0063-y     Document Type: Article

References (30)

1. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL: Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007, 35:1244-50.
2. Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R: Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA 2014, 311:1308-16.
3. Leligdowicz A, Dodek PM, Norena M, Wong H, Kumar A, Kumar A: Association between source of infection and hospital mortality in patients who have septic shock. Am J Resp Crit Care Med 2014, 189:1204-13.
4. Arndt P, Abraham E: Immunological therapies for sepsis. Intensive Care Med 2001, 27(S1):S104-15.
5. Kotsaki A, Giamarellos-Bourboulis EJ: Emerging drugs for the treatment of sepsis. Expert Opin Emerg Drugs 2012, 17:379-91.
6. Bouchon A, Dietrich J, Colonna M: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 2000, 164:4991-5.
7. Routsi C, Giamarellos-Bourboulis EJ, Antonopoulou A, Kollias S, Siasiakou S, Koronaios A, Zakynthinos S, Armaganidis A, Giamarellou H, Roussos C: Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock? Clin Exp Immunol 2005, 142:62-7.
8. Ford J, McVicar D: TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 2009, 21:38-46.
9. Dower K, Ellis DK, Saraf K, Jelinsky SA, Lin LL: Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide. J Immunol 2008, 180:3520-34.
10. Gibot S, Massin F, Marcou M, Taylor V, Stidwill R, Wilson P, Singer M, Bellingan G: TREM-1 promotes survival during septic shock in mice. Eur J Immunol 2007, 37:456-66.
11. Su L, Han B, Liu C, Liang L, Jiang Z, Deng J, Yan P, Jia Y, Feng D, Xie L: Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study. BMC Infect Dis 2012, 12:157.
12. Gibot S, Cravoisy A, Kolopp-Sarda MN, Béné MC, Faure G, Bollaert PE: Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit Care Med 2005, 33:792-6.
13. Giamarellos-Bourboulis EJ, Tsaganos T, Spyridaki E, Mouktaroudi M, Plachouras D, Vaki I, Karagianni V, Antonopoulou A, Veloni V, Giamarellou H: Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis. Crit Care 2006, 10:R166.
14. Adib-Conquy M, Cavaillon JM: Compensatory anti-inflammatory response syndrome. Thromb Haemost 2009, 101:36-47.
15. Dimopoulou I, Pelekanou A, Mavrou I, Savva A, Tzanela M, Kotsaki A, Kardara M, Orfanos SE, Kotanidou A, Giamarellos-Bourboulis EJ: Early serum levels of soluble triggering receptor expressed on myeloid cells-1 in septic patients: correlation with monocyte gene expression. J Crit Care 2012, 27:294-300.
16. Poukoulidou T, Spyridaki A, Michailidou I, Kopterides P, Pistiki A, Alexiou Z, Chrisofos M, Dimopoulou I, Drimoussis P, Giamarellos-Bourboulis EJ, Koutelidakis I, Marioli A, Mega A, Orfanos SE, Theodorakopoulou M, Tsironis C, Maggina N, Polychronopoulos V, Tsangaris I: TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the implicated pathogen. BMC Infect Dis 2011, 11:309.
17. Levy M, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G: 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 2003, 31:1250-6.
18. Christ-Crain M, Stolz D, Bingisser R, Müller C, Miedinger D, Huber PR, Zimmerli W, Harbarth S, Tamm M, Müller B: Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia. A randomized trial. Am J Respir Crit Care Med 2006, 174:84-93.
19. Pinson AG, Philbrick JT, Lindbeck GH, Schorling JB: Fever in the clinical diagnosis of acute pyelonephritis. Am J Emerg Med 1997, 15:148-51.
20. Calandra T, Cohen J: The international Sepsis Forum Consensus definitions of infections in the intensive care unit. Crit Care Med 2005, 33:1639-48.
21. Kollef MH: Appropriate antibiotic therapy for ventilator-associated pneumonia and sepsis: a necessity, not an issue for debate. Intensive Care Med 2003, 29:147-9.
22. Wang F, Liu S, Wu S, Zhu Q, Ou G, Liu C, Wang Y, Liao Y, Sun Z: Blocking TREM-1 signaling prolongs survival of mice with Pseudomonas aeruginosa induced sepsis. Cell Immunol 2012, 272:251-8.
23. Oku R, Oda S, Nakada TA, Sadahiro T, Nakamura M, Hirayama Y, Abe R, Tateishi Y, Ito M, Iseki T, Hirasawa H: Differential pattern of cell-surface and soluble TREM-1 between sepsis and SIRS. Cytokine 2013, 61:112-7.
24. Tao F, Peng L, Li J, Yao H: Association of serum myeloid cells of soluble triggering receptor-1 level with myocardial dysfunction in patients with severe sepsis. Mediators Inflamm 2013, 2013:819246.
25. Oda S, Sadahiro T, Hirayama Y, Abe R, Tateishi Y, Ito M, Iseki T, Hirasawa H: Differential pattern of cell-surface and soluble TREM-1 between sepsis and SIRS. Cytokine 2013, 61:112-7.
26. Kwan A, Hubank M, Rashid A, Klein N, Peters MJ: Transcriptional instability during evolving sepsis may limit biomarker based risk stratification. PLoS One 2013, 8:e60501.
27. Turrel-Davin F, Venet F, Monnin C, Barbalat V, Cerrato E, Pachot A, Lepape A, Alberti-Segui C, Monneret G: mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance. Crit Care 2011, 15:R252.
28. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003, 348:138-50.
29. Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD II, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS: Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011, 306:2594-605.
30. Leentjens J, Kox M, Koch RM, Preijers F, Joosten LA, van der Hoeven JG, Netea M, Pickkers P: Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study. Am J Respir Crit Care Med 2012, 186:838-45.