Myxochelins target human 5-lipoxygenase

Journal of Natural Products

Volumn 78, Issue 2, 2015, Pages 335-338

  Schieferdecker, Sebastian ^a   König, Stefanie ^a   Koeberle, Andreas ^a   Dahse, Hans Martin ^b   Werz, Oliver ^a   Nett, Markus ^a  

^a HANS KNÖLL INSTITUTE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT; ARACHIDONATE 5 LIPOXYGENASE; BACTERIAL ENZYME; CATECHOL DERIVATIVE; ENZYME INHIBITOR; MYXOCHELIN A ENZYME; MYXOCHELIN C ENZYME; MYXOCHELIN D ENZYME; UNCLASSIFIED DRUG; CURCUMIN; LIPOXYGENASE INHIBITOR; LYSINE; MYXOCHELIN A; SIDEROPHORE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BACTERIAL STRAIN; CELL DEATH; CELL PROLIFERATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HELA CELL LINE; HUMAN; HUMAN CELL; K562 CELL LINE; MYXOCOCCALES; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; ISOLATION AND PURIFICATION; METABOLISM; STEREOISOMERISM;

FALLAX;

ARACHIDONATE 5-LIPOXYGENASE; CURCUMIN; HELA CELLS; HUMANS; K562 CELLS; LIPOXYGENASE INHIBITORS; LYSINE; MOLECULAR STRUCTURE; MYXOCOCCALES; SIDEROPHORES; STEREOISOMERISM;

EID: 84923873746     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np500909b     Document Type: Article

References (30)

1. Wenzel, S. C.; Müller, R. Curr. Opin. Drug Discovery Dev. 2009, 12, 220-230
2. Schäberle, T. F.; Lohr, F.; Schmitz, A.; König, G. M. Nat. Prod. Rep. 2014, 31, 953-972
3. Nett, M.; König, G. M. Nat. Prod. Rep. 2007, 24, 1245-1261
4. Nett, M. In Progress in Chemistry of Organic Natural Products; Kinghorn, D. A.; Falk, H.; Kobayashi, J., Eds.; Springer: Switzerland, 2014; Vol. 99, pp 199-246.
5. Wenzel, S. C.; Müller, R. Nat. Prod. Rep. 2009, 26, 1385-1407
6. Xiao, Y.; Wei, X.; Ebright, R.; Wall, D. J. Bacteriol. 2011, 193, 4626-4633
7. Schieferdecker, S.; Exner, T. E.; Gross, H.; Roth, M.; Nett, M. J. Antibiot. 2014, 67, 519-525
8. Schieferdecker, S.; König, S.; Weigel, C.; Dahse, H.-M.; Werz, O.; Nett, M. Chem.-Eur. J. 2014, 20, 15933-15940
9. Surup, F.; Viehrig, K.; Mohr, K. I.; Herrmann, J.; Jansen, R.; Müller, R. Angew. Chem., Int. Ed. 2014, 53, 13588-13591
10. Kunze, B.; Bedorf, N.; Kohl, W.; Höfle, G.; Reichenbach, H. J. Antibiot. 1989, 42, 14-17
11. Silakowski, B.; Kunze, B.; Nordsiek, G.; Blöcker, H.; Höfle, G.; Müller, R. Eur. J. Biochem. 2000, 267, 6476-6485
12. Hong, J.; Bose, M.; Ju, J.; Ryu, J.-H.; Chen, X.; Sang, S.; Lee, M.-J.; Yang, C. S. Carcinogenesis 2004, 25, 1671-1679
13. Koeberle, A.; Muñoz, E.; Appendino, G. B.; Minassi, A.; Pace, S.; Rossi, A.; Weinigel, C.; Barz, D.; Sautebin, L.; Caprioglio, D.; Collado, J. A.; Werz, O. J. Med. Chem. 2014, 57, 5638-5648
14. Werz, O. Planta Med. 2007, 73, 1331-1357
15. Miyanaga, S.; Obata, T.; Onaka, H.; Fujita, T.; Saito, N.; Sakurai, H.; Saiki, I.; Furumai, T.; Igarashi, Y. J. Antibiot. 2006, 59, 698-703
16. Schwyn, B.; Neilands, J. B. Anal. Biochem. 1987, 160, 47-56
17. Wijeratne, E. M. K.; Bashyal, B. P.; Gunatilaka, M. K.; Arnold, A. E.; Gunatilaka, A. A. L. J. Nat. Prod. 2010, 73, 1156-1159
18. Miyanaga, S.; Sakurai, H.; Saiki, I.; Onaka, H.; Igarashi, Y. Bioorg. Med. Chem. 2009, 17, 2724-2732
19. Koeberle, A.; Northoff, H.; Werz, O. Mol. Cancer Ther. 2009, 8, 2348-2355
20. Rådmark, O.; Samuelsson, B. J. Int. Med. 2010, 268, 5-14
21. Chen, Y.; Hu, Y.; Zhang, H.; Peng, C.; Li, S. Nat. Genet. 2009, 41, 783-792
22. Roos, J.; Oancea, C.; Heinssmann, M.; Khan, D.; Held, H.; Kahnt, A. S.; Capelo, R.; la Buscato, E.; Proschak, E.; Puccetti, E.; Steinhilber, D.; Fleming, I.; Maier, T. J.; Ruthardt, M. Cancer Res. 2014, 18, 5244-5255
23. Li, Y.; Yin, S.; Nie, D.; Xie, S.; Ma, L.; Wang, X.; Wu, Y.; Xiao, J. Int. J. Hematol. 2011, 5, 472-478
24. Ogmundsdóttir, H. M.; Zoëga, G. M.; Gissurarson, S. R.; Ingólfsdóttir, K. J. Pharm. Pharmacol. 1998, 50, 107-115
25. Gilbert, N. C.; Bartlett, S. G.; Waight, M. T.; Neau, D. B.; Boeglin, W. E.; Brash, A. R.; Newcomer, M. E. Science 2011, 331, 217-219
26. Ford-Hutchinson, A. W.; Gresser, M.; Young, R. N. Annu. Rev. Biochem. 1994, 63, 383-417
27. Hostanska, K.; Daum, G.; Saller, R. Anticancer Res. 2002, 22, 2853-2862
28. Krauth, F.; Dahse, H.-M.; Rüttinger, H.-H.; Frohberg, P. Bioorg. Med. Chem. 2010, 18, 1816-1821
29. Fischer, L.; Szellas, D.; Rådmark, O.; Steinhilber, D.; Werz, O. FASEB J. 2003, 8, 949-951
30. Werz, O.; Bürkert, E.; Samuelsson, B.; Rådmark, O.; Steinhilber, D. Blood 2002, 3, 1044-1052