M2 macrophage infiltrates in the early stages of ANCA-associated pauci-immune necrotizing GN

Clinical Journal of the American Society of Nephrology

Volumn 10, Issue 1, 2015, Pages 54-63

  Zhao, Lei ^a   David, Michael Z ^b   Hyjek, Elizabeth ^c   Chang, Anthony ^a   Meehan, Shane M ^a  

^a Chicago Department of Health   (United States)

^b UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD163 ANTIGEN; CD3 ANTIGEN; CD68 ANTIGEN; CREATININE; NEUTROPHIL CYTOPLASMIC ANTIBODY; BIOLOGICAL MARKER; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; B LYMPHOCYTE; CAPILLARY LEAK SYNDROME; CELL INFILTRATION; CHILD; CONTROLLED STUDY; EFFECTOR CELL; ELECTRON MICROSCOPY; FEMALE; GLOMERULAR FIBRINOID NECROSIS; HUMAN; HUMAN TISSUE; IMMUNE COMPLEX NEPHRITIS; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; MACROPHAGE; MALE; NATURAL KILLER CELL; NEUTROPHIL; PAUCI IMMUNE NECROTIZING GLOMERULONEPHRITIS; T LYMPHOCYTE; ANCA ASSOCIATED VASCULITIS; BIOPSY; BLOOD; CAPILLARY; CHEMOTAXIS; GLOMERULONEPHRITIS; GLOMERULUS; IMMUNOLOGY; MACROPHAGE ACTIVATION; MIDDLE AGED; NECROSIS; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHENOTYPE; PRESCHOOL CHILD; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BIOMARKERS; BIOPSY; CAPILLARIES; CHEMOTAXIS; CHILD; CHILD, PRESCHOOL; CREATININE; FEMALE; GLOMERULONEPHRITIS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY GLOMERULUS; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; NECROSIS; NEUTROPHIL INFILTRATION; PHENOTYPE; RECEPTORS, CELL SURFACE; YOUNG ADULT;

EID: 84923856500     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.03230314     Document Type: Article

References (34)

1. Jennette JC, Thomas DB: Pauci-immune and antineutrophil cytoplasmic autoantibody-mediated crescentic glomerulonephritis and vasculitis. In: Heptinstall’s Pathology of the Kidney, 6th Ed., edited by Jennette JC, Olson JL, Schwartz MM, Silva FG, Philadelphia, Lippincott Williams & Wilkins, 2007, pp 643–673.
2. Franssen CF, Huitema MG, Muller Kobold AC, Oost-Kort WW, Limburg PC, Tiebosch A, Stegeman CA, Kallenberg CG, Tervaert JW: In vitro neutrophil activation by antibodies to proteinase 3 and myeloperoxidase from patients with crescentic glomerulonephritis. J Am Soc Nephrol 10: 1506–1515, 1999.
3. Kettritz R, Jennette JC, Falk RJ: Crosslinking of ANCA-antigens stimulates superoxide release by human neutrophils. J Am Soc Nephrol 8: 386–394, 1997.
4. Muller Kobold AC, van der Geld YM, Limburg PC, Tervaert JW, Kallenberg CG: Pathophysiology of ANCA-associated glomerulonephritis. Nephrol Dial Transplant 14: 1366–1375, 1999.
5. Falk RJ, Jennette JC: ANCA disease: Where is this field heading? J Am Soc Nephrol 21: 745–752, 2010.
6. Jennette JC, Falk RJ, Gasim AH: Pathogenesis of antineutrophil cytoplasmic autoantibody vasculitis. Curr Opin Nephrol Hypertens 20: 263–270, 2011.
7. Kambham N: Crescentic glomerulonephritis: An update on pauci-immune and anti-GBMdiseases. Adv Anat Pathol 19: 111–124, 2012.
8. Tipping PG, Holdsworth SR: T cells in crescentic glomerulonephritis. J Am Soc Nephrol 17: 1253–1263, 2006.
9. Ruth A-J, Kitching AR, Kwan RYQ, Odobasic D, Ooi JDK, Timoshanko JR, Hickey MJ, Holdsworth SR: Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis. J Am Soc Nephrol 17: 1940–1949, 2006.
10. Yoshioka K, Takemura T, Akano N, Miyamoto H, Iseki T, Maki S: Cellular and non-cellular compositions of crescents in human glomerulonephritis. Kidney Int 32: 284–291, 1987.
11. Cunningham MA, Huang XR, Dowling JP, Tipping PG, Holdsworth SR: Prominence of cell-mediated immunity effectors in “pauci-immune” glomerulonephritis. J Am Soc Nephrol 10: 499–506, 1999.
12. Rastaldi MP, Ferrario F, Crippa A, Dell’Antonio G, Casartelli D, Grillo C, D’Amico G: Glomerular monocyte-macrophage features in ANCA-positive renal vasculitis and cryoglobulinemic nephritis. J Am Soc Nephrol 11: 2036–2043, 2000.
13. Weidner S, Carl M, Riess R, Rupprecht HD: Histologic analysis of renal leukocyte infiltration in antineutrophil cytoplasmic antibody-associated vasculitis: Importance of monocyte and neutrophil infiltration in tissue damage. Arthritis Rheum 50: 3651–3657, 2004.
14. Couser WG: Basic and translational concepts of immune-mediated glomerular diseases. J Am Soc Nephrol 23: 381–399, 2012.
15. Solez K, Colvin RB, Racusen LC, Haas M, Sis B, Mengel M, Halloran PF, Baldwin W, Banfi G, Collins AB, Cosio F, David DSR, Drachenberg C, Einecke G, Fogo AB, Gibson IW, Glotz D, Iskandar SS, Kraus E, Lerut E, Mannon RB, Mihatsch M, Nankivell BJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Roberts I, Seron D, Smith RN, Valente M: Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 8: 753–760, 2008.
16. Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K, Neumann I, Noel L-H, Pusey CD, Waldherr R, Bruijn JA, Bajema IM: Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol 21: 1628–1636, 2010.
17. Hancock WW, Atkins RC: Cellular composition of crescents in human rapidly progressive glomerulonephritis identified using monoclonal antibodies. Am J Nephrol 4: 177–181, 1984.
18. Bolton WK, Innes DJ Jr., Sturgill BC, Kaiser DL: T-cells and macrophages in rapidly progressive glomerulonephritis: Clinicopathologic correlations. Kidney Int 32: 869–876, 1987.
19. Aasarød K, Bostad L, Hammerstrøm J, Jørstad S, Iversen BM: Wegener’s granulomatosis: Inflammatory cells and markers of repair and fibrosis in renal biopsies—a clinicopathological study. Scand J Urol Nephrol 35: 401–410, 2001.
20. Boucher A, Droz D, Adafer E, Noel LH: Relationship between the integrity of Bowman’s capsule and the composition of cellular crescents in human crescentic glomerulonephritis. Lab Invest 56: 526–533, 1987.
21. Morita T, Suzuki Y, Churg J: Structure and development of the glomerular crescent. Am J Pathol 72: 349–368, 1973.
22. Bohman SO, Olsen S, Petersen VP: Glomerular ultrastructure in extracapillary glomerulonephritis. Acta Pathol Microbiol Scand Suppl 249[Suppl]: 29–54, 1974.
23. Stejskal J, Pirani CL, Okada M, Mandelanakis N, Pollak VE: Discontinuities (gaps) of the glomerular capillary wall and basement membrane in renal diseases. Lab Invest 28: 149–169, 1973.
24. Le Hir M, Keller C, Eschmann V, Hahnel B, Hosser H, Kriz W: Podocyte bridges between the tuft and Bowman’s capsule: An early event in experimental crescentic glomerulonephritis. J Am Soc Nephrol 12: 2060–2071, 2001.
25. Nowack R, Schwalbe K, Flores-Suarez LF, Yard B, van der Woude FJ: Upregulation of CD14 and CD18 on monocytes in vitro by antineutrophil cytoplasmic autoantibodies. J Am Soc Nephrol 11: 1639–1646, 2000.
26. Le Hir M: Histopathology of humorally mediated anti-glomerular basement membrane (GBM) glomerulonephritis in mice. Nephrol Dial Transplant 19: 1875–1880, 2004.
27. Ritter M, Buechler C, Langmann T, Orso E, Klucken J, Schmitz G: The scavenger receptor CD163: Regulation, promoter structure and genomic organization. Pathobiology 67: 257–261, 1999.
28. Akila P, Prashant V, Suma MN, Prashant SN, Chaitra TR: CD163 and its expanding functional repertoire. Clin Chim Acta 413: 669–674, 2012.
29. Etzerodt A, Moestrup SK: CD163 and inflammation: Biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal 18: 2352–2363, 2013.
30. Barros MHM, Hauck F, Dreyer JH, Kempkes B, Niedobitek G: Macrophage polarisation: An immunohistochemical approach for identifying M1 andM2 macrophages. PLoS ONE 8: e80908, 2013.
31. Erwig L-P, Kluth DC, Rees AJ: Macrophage heterogeneity in renal inflammation. Nephrol Dial Transplant 18: 1962–1965, 2003.
32. Pepper RJ, Hamour S, Chavele K-M, Todd SK, Rasmussen N, Flint S, Lyons PA, Smith KGC, Pusey CD, Cook HT, Salama AD: Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis. Kidney Int 83: 1150–1158, 2013.
33. Furlong TJ, Ibels LS, Eckstein RP: The clinical spectrum of necrotizing glomerulonephritis. Medicine (Baltimore) 66: 192–201, 1987.
34. Rastaldi MP, Ferrario F, Tunesi S, Yang L, D’Amico G: Intraglomerular and interstitial leukocyte infiltration, adhesion molecules, and interleukin-1 alpha expression in 15 cases of antineutrophil cytoplasmic autoantibody-associated renal vasculitis. Am J Kidney Dis 27: 48–57, 1996.