The post-PE syndrome: A new concept for chronic complications of pulmonary embolism

Blood Reviews

Volumn 28, Issue 6, 2014, Pages 221-226

  Klok, F A ^a   van der Hulle, T ^b   den Exter, P L ^b   Lankeit, M ^a   Huisman, M V ^b   Konstantinides, S ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Chronic thromboembolic pulmonary hypertension; Exercise tolerance; Pulmonary artery pressure; Pulmonary embolism; Quality of life; Right ventricular function

Indexed keywords

ACUTE DISEASE; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; DEEP VEIN THROMBOSIS; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DYSPNEA; ECHOCARDIOGRAPHY; FOLLOW UP; FUNCTIONAL ASSESSMENT; FUNCTIONAL DISEASE; HEMODYNAMICS; HUMAN; LUNG EMBOLISM; PATHOPHYSIOLOGY; PHYSICAL PERFORMANCE; POST PULMONARY EMBOLISM SYNDROME; POSTTHROMBOSIS SYNDROME; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; CHRONIC DISEASE; COMPLICATION;

ANTICOAGULANT AGENT;

ANTICOAGULANTS; CHRONIC DISEASE; HUMANS; PULMONARY EMBOLISM; QUALITY OF LIFE;

EID: 84923834602     PISSN: 0268960X     EISSN: 15321681     Source Type: Journal    
DOI: 10.1016/j.blre.2014.07.003     Document Type: Article

References (79)

1. Prandoni P., Lensing A.W., Cogo A., et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 1996, 125:1-7.
2. Kahn S.R., Shrier I., Julian J.A., et al. Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis. Ann Intern Med 2008, 149:698-707.
3. Kahn S.R. The post thrombotic syndrome. Thromb Res 2011, 127(Suppl. 3):S89-S92.
4. Baldwin M.J., Moore H.M., Rudarakanchana N., Gohel M., Davies A.H. Post-thrombotic syndrome: a clinical review. J Thromb Haemost 2013, 11:795-805.
5. Kahn S.R., Shbaklo H., Lamping D.L., et al. Determinants of health-related quality of life during the 2years following deep vein thrombosis. J Thromb Haemost 2008, 6:1105-1112.
6. Klok F.A., Tijmensen J.E., Haeck M.L., van Kralingen K.W., Huisman M.V. Persistent dyspnea complaints at long-term follow-up after an episode of acute pulmonary embolism: results of a questionnaire. Eur J Intern Med 2008, 19:625-629.
7. Klok F.A., van Kralingen K.W., van Dijk A.P., et al. Quality of life in long-term survivors of acute pulmonary embolism. Chest 2010, 138:1432-1440.
8. Lang I.M., Pesavento R., Bonderman D., Yuan J.X. Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding. Eur Respir J 2013, 41:462-468.
9. Klok F.A., Mos I.C., van Kralingen K.W., Vahl J.E., Huisman M.V. Chronic pulmonary embolism and pulmonary hypertension. Semin Respir Crit Care Med 2012, 33:199-204.
10. van Ramshorst B., van Bemmelen P.S., Hoeneveld H., Faber J.A., Eikelboom B.C. Thrombus regression in deep venous thrombosis. Quantification of spontaneous thrombolysis with duplex scanning. Circulation 1992, 86:414-419.
11. Prandoni P., Lensing A.W., Prins M.H., et al. Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern Med 2002, 137:955-960.
12. Krupski W.C., Bass A., Dilley R.B., Bernstein E.F., Otis S.M. Propagation of deep venous thrombosis identified by duplex ultrasonography. J Vasc Surg 1990, 12:467-474.
13. Markel A., Meissner M., Manzo R.A., Bergelin R.O., Strandness D.E. Deep venous thrombosis: rate of spontaneous lysis and thrombus extension. Int Angiol 2003, 22:376-382.
14. Latella J., Desmarais S., Miron M.J., et al. Relation between D-dimer level, venous valvular reflux and the development of post-thrombotic syndrome after deep vein thrombosis. J Thromb Haemost 2010, 8:2169-2175.
15. O'shaughnessy A.M., Fitzgerald D.E. The patterns and distribution of residual abnormalities between the individual proximal venous segments after an acute deep vein thrombosis. J Vasc Surg 2001, 33:379-384.
16. Eberhardt R.T., Raffetto J.D. Chronic venous insufficiency. Circulation 2005, 111:2398-2409.
17. Wagenvoort C.A. Pathology of pulmonary thromboembolism. Chest 1995, 107:10S-17S.
18. Rosenberg R.D., Aird W.C. Vascular-bed-specific hemostasis and hypercoagulable states. N Engl J Med 1999, 340:1555-1564.
19. Dong B.R., Hao Q., Yue J., Wu T., Liu G.J. Thrombolytic therapy for pulmonary embolism. Cochrane Database Syst Rev 2009, 3:CD004437.
20. Alonso-Martinez J.L., Anniccherico-Sanchez F.J., Urbieta-Echezarreta M.A., Garcia-Sanchotena J.L., Herrero H.G. Residual pulmonary thromboemboli after acute pulmonary embolism. Eur J Intern Med 2012, 23:379-383.
21. Cosmi B., Nijkeuter M., Valentino M., Huisman M.v., Barozzi L., Palareti G. Residual emboli on lung perfusion scan or multidetector computed tomography after a first episode of acute pulmonary embolism. Intern Emerg Med 2011, 6:521-528.
22. Stein P.D., Yaekoub A.Y., Matta F., et al. Resolution of pulmonary embolism on CT pulmonary angiography. AJR Am J Roentgenol 2010, 194:1263-1268.
23. Miniati M., Monti S., Bottai M., et al. Survival and restoration of pulmonary perfusion in a long-term follow-up of patients after acute pulmonary embolism. Medicine (Baltimore) 2006, 85:253-262.
24. Golpe R., de Llano L.A., Castro-Anon O., Vázquez-Caruncho M., González-Juanatey C., Fariñas M.C. Long-term outcome of patients with persistent vascular obstruction on computed tomography pulmonary angiography 6months after acute pulmonary embolism. Acta Radiol 2012, 53:728-731.
25. Sanchez O., Helley D., Couchon S., et al. Perfusion defects after pulmonary embolism: risk factors and clinical significance. J Thromb Haemost 2010, 8:1248-1255.
26. Korkmaz A., Ozlu T., Ozsu S., Kazaz Z., Bulbul Y. Long-term outcomes in acute pulmonary thromboembolism: the incidence of chronic thromboembolic pulmonary hypertension and associated risk factors. Clin Appl Thromb Hemost 2012, 18:281-288.
27. Aghayev A., Furlan A., Patil A., et al. The rate of resolution of clot burden measured by pulmonary CT angiography in patients with acute pulmonary embolism. AJR Am J Roentgenol 2013, 200:791-797.
28. Kaczynska A., Kostrubiec M., Pacho R., Kunikowska J., Pruszczyk P. Elevated D-dimer concentration identifies patients with incomplete recanalization of pulmonary artery thromboemboli despite 6months anticoagulation after the first episode of acute pulmonary embolism. Thromb Res 2008, 122:21-25.
29. Wartski M., Collignon M.A. Incomplete recovery of lung perfusion after 3months in patients with acute pulmonary embolism treated with antithrombotic agents. THESEE Study Group. Tinzaparin ou Heparin Standard: Evaluation dans l'Embolie Pulmonaire Study. J Nucl Med 2000, 41:1043-1048.
30. Begic A., Jogi J., Hadziredzepovic A., Kucukalic-Selimović E., Begovic-Hadzimuratovic S., Bajc M. Tomographic ventilation/perfusion lung scintigraphy in the monitoring of the effect of treatment in pulmonary embolism: serial follow-up over a 6-month period. Nucl Med Commun 2011, 32:508-514.
31. van Es J., Douma R.A., Kamphuisen P.W., et al. Clot resolution after 3weeks of anticoagulant treatment for pulmonary embolism: comparison of computed tomography and perfusion scintigraphy. J Thromb Haemost 2013, 11:679-685.
32. Morris T.A. Why acute pulmonary embolism becomes chronic thromboembolic pulmonary hypertension: clinical and genetic insights. Curr Opin Pulm Med 2013, 19:422-429.
33. Arbustini E., Morbini P., D'Armini A.M., et al. Plaque composition in plexogenic and thromboembolic pulmonary hypertension: the critical role of thrombotic material in pultaceous core formation. Heart 2002, 88:177-182.
34. Bernard J., Yi E.S. Pulmonary thromboendarterectomy: a clinicopathologic study of 200 consecutive pulmonary thromboendarterectomy cases in one institution. Hum Pathol 2007, 38:871-877.
35. Olman M.A., Marsh J.J., Lang I.M., Moser K.M., Binder B.R., Schleef R.R. Endogenous fibrinolytic system in chronic large-vessel thromboembolic pulmonary hypertension. Circulation 1992, 86:1241-1248.
36. Morris T.A., Marsh J.J., Chiles P.G., et al. Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis. Am J Respir Crit Care Med 2006, 173:1270-1275.
37. Morris T.A., Marsh J.J., Chiles P.G., et al. High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension. Blood 2009, 114:1929-1936.
38. Miniati M., Fiorillo C., Becatti M., et al. Fibrin resistance to lysis in patients with pulmonary hypertension other than thromboembolic. Am J Respir Crit Care Med 2010, 181:992-996.
39. Suntharalingam J., Goldsmith K., van M V., et al. Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension. Eur Respir J 2008, 31:736-741.
40. Li J.F., Lin Y., Yang Y.H., et al. Fibrinogen Aalpha Thr312Ala polymorphism specifically contributes to chronic thromboembolic pulmonary hypertension by increasing fibrin resistance. PLoS One 2013, 8:e69635.
41. Wolf M., Boyer-Neumann C., Parent F., et al. Thrombotic risk factors in pulmonary hypertension. Eur Respir J 2000, 15:395-399.
42. Alias S., Redwan B., Panzenboeck A., et al. Defective angiogenesis delays thrombus resolution: a potential pathogenetic mechanism underlying chronic thromboembolic pulmonary hypertension. Arterioscler Thromb Vasc Biol 2014, 34:810-819.
43. Thompson W.D., Smith E.B., Stirk C.M., Marshall F.I., Stout A.J., Kocchar A. Angiogenic activity of fibrin degradation products is located in fibrin fragment E. J Pathol 1992, 168:47-53.
44. Zabini D., Nagaraj C., Stacher E., et al. Angiostatic factors in the pulmonary endarterectomy material from chronic thromboembolic pulmonary hypertension patients cause endothelial dysfunction. PLoS One 2012, 7:e43793.
45. Bonderman D., Jakowitsch J., Redwan B., et al. Role for staphylococci in misguided thrombus resolution of chronic thromboembolic pulmonary hypertension. Arterioscler Thromb Vasc Biol 2008, 28:678-684.
46. Kearon C. Natural history of venous thromboembolism. Circulation 2003, 107:I22-I30.
47. Ribeiro A., Lindmarker P., Johnsson H., Juhlin-Dannfelt A., Jorfeldt L. Pulmonary embolism: one-year follow-up with echocardiography Doppler and five-year survival analysis. Circulation 1999, 99:1325-1330.
48. Stevinson B.G., Hernandez-Nino J., Rose G., Kline J.A. Echocardiographic and functional cardiopulmonary problems 6months after first-time pulmonary embolism in previously healthy patients. Eur Heart J 2007, 28:2517-2524.
49. Kline J.A., Steuerwald M.T., Marchick M.R., Hernandez-Nino J., Rose G.A. Prospective evaluation of right ventricular function and functional status 6months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure. Chest 2009, 136:1202-1210.
50. Grifoni S., Vanni S., Magazzini S., et al. Association of persistent right ventricular dysfunction at hospital discharge after acute pulmonary embolism with recurrent thromboembolic events. Arch Intern Med 2006, 166:2151-2156.
51. Riedel M., Stanek V., Widimsky J., Prerovsky I. Longterm follow-up of patients with pulmonary thromboembolism. Late prognosis and evolution of hemodynamic and respiratory data. Chest 1982, 81:151-158.
52. Klok F.A., Huisman M.V. Epidemiology and management of chronic thromboembolic pulmonary hypertension. Neth J Med 2010, 68:347-351.
53. Ghamra Z.W., Dweik R.A. Primary pulmonary hypertension: an overview of epidemiology and pathogenesis. Cleve Clin J Med 2003, 70(Suppl. 1):S2-S8.
54. Nagel C., Prange F., Guth S., et al. Exercise training improves exercise capacity and quality of life in patients with inoperable or residual chronic thromboembolic pulmonary hypertension. PLoS One 2012, 7:e41603.
55. Mereles D., Ehlken N., Kreuscher S., et al. Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation 2006, 114:1482-1489.
56. Ulrich S., Speich R., Domenighetti G., et al. Bosentan therapy for chronic thromboembolic pulmonary hypertension. A national open label study assessing the effect of Bosentan on haemodynamics, exercise capacity, quality of life, safety and tolerability in patients with chronic thromboembolic pulmonary hypertension (BOCTEPH-Study). Swiss Med Wkly 2007, 137:573-580.
57. Pengo V., Lensing A.W., Prins M.H., et al. Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med 2004, 350:2257-2264.
58. Otero R., Oribe M., Ballaz A., et al. Echocardiographic assessment of pulmonary arterial pressure in the follow-up of patients with pulmonary embolism. Thromb Res 2011, 127:303-308.
59. Meneveau N., Ider O., Seronde M.F., et al. Long-term prognostic value of residual pulmonary vascular obstruction at discharge in patients with intermediate- to high-risk pulmonary embolism. Eur Heart J 2013, 34:693-701.
60. Klok F.A., van Kralingen K.W., van Dijk A.P., et al. Prospective cardiopulmonary screening program to detect chronic thromboembolic pulmonary hypertension in patients after acute pulmonary embolism. Haematologica 2010, 95:970-975.
61. Poli D., Grifoni E., Antonucci E., et al. Incidence of recurrent venous thromboembolism and of chronic thromboembolic pulmonary hypertension in patients after a first episode of pulmonary embolism. J Thromb Thrombolysis 2010, 30:294-299.
62. Becattini C., Agnelli G., Pesavento R., et al. Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism. Chest 2006, 130:172-175.
63. Azarian R., Wartski M., Collignon M.A., et al. Lung perfusion scans and hemodynamics in acute and chronic pulmonary embolism. J Nucl Med 1997, 38:980-983.
64. Kim H., Yung G.L., Marsh J.J., et al. Pulmonary vascular remodeling distal to pulmonary artery ligation is accompanied by upregulation of endothelin receptors and nitric oxide synthase. Exp Lung Res 2000, 26:287-301.
65. Moser K.M., Bloor C.M. Pulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertension. Chest 1993, 103:685-692.
66. Klok F.A., van Kralingen K.W., van Dijk A.P., et al. Prevalence and potential determinants of exertional dyspnea after acute pulmonary embolism. Respir Med 2010, 104:1744-1749.
67. Benotti J.R., Ockene I.S., Alpert J.S., Dalen J.E. The clinical profile of unresolved pulmonary embolism. Chest 1983, 84:669-678.
68. Prediletto R., Formichi B., Begliomini E., et al. Ventilation-perfusion heterogeneity and gas exchange variables in acute pulmonary embolism evaluated by two different computerized techniques. Int J Clin Monit Comput 1988, 5:221-227.
69. Kline J.A., Kubin A.K., Patel M.M., Easton E.J., Seupal R.A. Alveolar dead space as a predictor of severity of pulmonary embolism. Acad Emerg Med 2000, 7:611-617.
70. Michard F., Meyer G., Wysocki M., Diehl J.L., Mercat A., Sors H. Cardiorespiratory efficacy of thrombolytic therapy in acute massive pulmonary embolism: identification of predictive factors. Eur Respir J 1999, 13:610-615.
71. McCabe C., Deboeck G., Harvey I., et al. Inefficient exercise gas exchange identifies pulmonary hypertension in chronic thromboembolic obstruction following pulmonary embolism. Thromb Res 2013, 132:659-665.
72. van Es J., den Exter P.L., Kaptein A.A., et al. Quality of life after pulmonary embolism as assessed with SF-36 and PEmb-QoL. Thromb Res 2013, 132:500-505.
73. Hogg K., Kimpton M., Carrier M., Coyle D., Forgie M., Wells P. Estimating quality of life in acute venous thrombosis. JAMA Int Med 2013, 173:1067-1072.
74. Klok F.A., Cohn D.M., Middeldorp S., et al. Quality of life after pulmonary embolism: validation of the PEmb-QoL Questionnaire. J Thromb Haemost 2010, 8:523-532.
75. Abstracts of the XXIV Congress of the International Society on Thrombosis and Haemostasis. June 29-July 4, 2013. Amsterdam, The Netherlands. Abstract number PA 3.06-2. J Thromb Haemost 2013, 11(Suppl. 2):1-1322.
76. Lukas P.S., Krummenacher R., Biasiutti F.D., Begré S., Znoj H., von Känel R. Association of fatigue and psychological distress with quality of life in patients with a previous venous thromboembolic event. Thromb Haemost 2009, 102:1219-1226.
77. Roman A., Barbera J.A., Castillo M.J., Munoz R., Escribano P. Health-related quality of life in a national cohort of patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension. Arch Bronconeumol 2013, 49:181-188.
78. Yoshimi S., Tanabe N., Masuda M., et al. Survival and quality of life for patients with peripheral type chronic thromboembolic pulmonary hypertension. Circ J 2008, 72:958-965.
79. Archibald C.J., Auger W.R., Fedullo P.F., et al. Long-term outcome after pulmonary thromboendarterectomy. Am J Respir Crit Care Med 1999, 160:523-528.