메뉴 건너뛰기




Volumn 57, Issue 3, 2015, Pages 219-232

Carrot Cells: A Pioneering Platform for Biopharmaceuticals Production

Author keywords

Cell suspension; Edible plant; Hairy roots; Oral vaccination; Plant based vaccine; Recombinant vaccine

Indexed keywords

CELL CULTURE; ESCHERICHIA COLI; VACCINES;

EID: 84923812779     PISSN: 10736085     EISSN: 15590305     Source Type: Journal    
DOI: 10.1007/s12033-014-9837-y     Document Type: Review
Times cited : (48)

References (93)
  • 2
    • 84886897589 scopus 로고    scopus 로고
    • Role of plant expression systems in antibody production for passive immunization
    • COI: 1:CAS:528:DC%2BC2cXksF2rtrk%3D
    • Virdi, V., & Depicker, A. (2013). Role of plant expression systems in antibody production for passive immunization. The International Journal of Developmental Biology,57(6–8), 587–593.
    • (2013) The International Journal of Developmental Biology , vol.57 , Issue.6-8 , pp. 587-593
    • Virdi, V.1    Depicker, A.2
  • 3
    • 84891930928 scopus 로고    scopus 로고
    • Molecular farming of human cytokines and blood products from plants: Challenges in biosynthesis and detection of plant-produced recombinant proteins
    • da Cunha, N. B., Vianna, G. R., da Almeida Lima, T., & Rech, E. (2014). Molecular farming of human cytokines and blood products from plants: Challenges in biosynthesis and detection of plant-produced recombinant proteins. Biotechnology Journal,9(1), 39–50.
    • (2014) Biotechnology Journal , vol.9 , Issue.1 , pp. 39-50
    • da Cunha, N.B.1    Vianna, G.R.2    da Almeida Lima, T.3    Rech, E.4
  • 4
    • 34547586616 scopus 로고    scopus 로고
    • Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher’s disease using a plant cell system
    • COI: 1:CAS:528:DC%2BD2sXhtVemt7bM
    • Shaaltiel, Y., Bartfeld, D., Hashmueli, S., Baum, G., Brill-Almon, E., Galili, G., et al. (2007). Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher’s disease using a plant cell system. Plant Biotechnology Journal,5(5), 579–590.
    • (2007) Plant Biotechnology Journal , vol.5 , Issue.5 , pp. 579-590
    • Shaaltiel, Y.1    Bartfeld, D.2    Hashmueli, S.3    Baum, G.4    Brill-Almon, E.5    Galili, G.6
  • 5
    • 84923820560 scopus 로고    scopus 로고
    • Protalix. Retrieved October, 2014 from.
    • Protalix. Retrieved October, 2014 from http://www.protalix.com/index.asp.
  • 6
    • 0242417615 scopus 로고    scopus 로고
    • Neutralizing immunogenicity of transgenic carrot (Daucus carota L.)-derived measles virus hemagglutinin
    • COI: 1:CAS:528:DC%2BD3sXhtFCqtLg%3D
    • Marquet-Blouin, E., Bouche, F. B., Steinmetz, A., & Muller, C. P. (2003). Neutralizing immunogenicity of transgenic carrot (Daucus carota L.)-derived measles virus hemagglutinin. Plant Molecular Biology,51(4), 459–469.
    • (2003) Plant Molecular Biology , vol.51 , Issue.4 , pp. 459-469
    • Marquet-Blouin, E.1    Bouche, F.B.2    Steinmetz, A.3    Muller, C.P.4
  • 7
    • 84923771669 scopus 로고    scopus 로고
    • Food and Agriculture Organization of the United Sations Statistics Division (FAOSTAT). Retrieved October, 2014 from.
    • Food and Agriculture Organization of the United Sations Statistics Division (FAOSTAT). Retrieved October, 2014 from http://faostat3.fao.org/faostat-gateway/go/to/home/E.
  • 8
    • 84923797173 scopus 로고    scopus 로고
    • United States Department of Agriculture (USDA). Retrieved October, 2014 from.
    • United States Department of Agriculture (USDA). Retrieved October, 2014 from http://nutritiondata.self.com/facts/vegetables-and-vegetable-products/2383/2.
  • 9
    • 0012469446 scopus 로고
    • Growth and development of cultured cells. III. Interpretation of the growth from free cells to carrot plant
    • Steward, F. C. (1958). Growth and development of cultured cells. III. Interpretation of the growth from free cells to carrot plant. American Journal of Botany,45, 709–713.
    • (1958) American Journal of Botany , vol.45 , pp. 709-713
    • Steward, F.C.1
  • 10
    • 0001619450 scopus 로고
    • Growth and development of cultured cells. I. Growth and division of freely suspended cells
    • Steward, F. C., Mapes, M. O., & Smith, J. (1958). Growth and development of cultured cells. I. Growth and division of freely suspended cells. American Journal of Botany,45, 693–713.
    • (1958) American Journal of Botany , vol.45 , pp. 693-713
    • Steward, F.C.1    Mapes, M.O.2    Smith, J.3
  • 11
    • 79851483317 scopus 로고    scopus 로고
    • Genetic transformation of carrot (Daucus carota) and other Apiaceae species
    • Baranski, R. (2008). Genetic transformation of carrot (Daucus carota) and other Apiaceae species. Transgenic Plant Journal,2, 18–38.
    • (2008) Transgenic Plant Journal , vol.2 , pp. 18-38
    • Baranski, R.1
  • 13
    • 51649144691 scopus 로고
    • Shear sensitivity of plant cells in suspensions present and future
    • COI: 1:CAS:528:DyaK2MXoslWmt74%3D
    • Namdev, P. K., & Dunlop, E. H. (1995). Shear sensitivity of plant cells in suspensions present and future. Applied Biochemistry Biotechnology,54(1–3), 109–131.
    • (1995) Applied Biochemistry Biotechnology , vol.54 , Issue.1-3 , pp. 109-131
    • Namdev, P.K.1    Dunlop, E.H.2
  • 14
    • 0242554088 scopus 로고
    • Somaclonal variation—A novel source of variability from cell cultures for plant improvement
    • COI: 1:STN:280:DC%2BC2c3gslGgtQ%3D%3D
    • Larkin, P. J., & Scowcroft, W. R. (1981). Somaclonal variation—A novel source of variability from cell cultures for plant improvement. Theoretical and Applied Genetics,60, 197–214.
    • (1981) Theoretical and Applied Genetics , vol.60 , pp. 197-214
    • Larkin, P.J.1    Scowcroft, W.R.2
  • 16
    • 0347127989 scopus 로고
    • Transformation of Daucus carota hypocotyls mediated by Agrobacterium tumefaciens
    • Balestrazzi, A., Carbonera, D., & Cella, R. (1991). Transformation of Daucus carota hypocotyls mediated by Agrobacterium tumefaciens. Journal of Genetics and Breeding,45, 135–140.
    • (1991) Journal of Genetics and Breeding , vol.45 , pp. 135-140
    • Balestrazzi, A.1    Carbonera, D.2    Cella, R.3
  • 17
    • 0031970724 scopus 로고    scopus 로고
    • Transformation and regeneration of carrot (Daucus carota L.)
    • COI: 1:CAS:528:DyaK1cXjtFeiurs%3D
    • Hardegger, M., & Sturm, A. (1998). Transformation and regeneration of carrot (Daucus carota L.). Molecular Breeding,4, 119–127.
    • (1998) Molecular Breeding , vol.4 , pp. 119-127
    • Hardegger, M.1    Sturm, A.2
  • 18
    • 0000481969 scopus 로고
    • Factors influencing the Agrobacterium tumefaciens-mediated transformation of carrot (Daucus carota L.)
    • COI: 1:CAS:528:DyaK3sXhs1Wqsbo%3D
    • Pawlicki, N., Sangwan, R., & Sangwan-Norrel, B. (1992). Factors influencing the Agrobacterium tumefaciens-mediated transformation of carrot (Daucus carota L.). Plant Cell, Tissue and Organ Culture,31, 129–139.
    • (1992) Plant Cell, Tissue and Organ Culture , vol.31 , pp. 129-139
    • Pawlicki, N.1    Sangwan, R.2    Sangwan-Norrel, B.3
  • 20
  • 21
    • 38349163622 scopus 로고    scopus 로고
    • Comparative expression of beta-glucuronidase with five different promoters in transgenic carrot (Daucus carota L.) root and leaf tissues
    • COI: 1:CAS:528:DC%2BD1cXosFSqug%3D%3D
    • Wally, O., Jayaraj, J., & Punja, Z. K. (2008). Comparative expression of beta-glucuronidase with five different promoters in transgenic carrot (Daucus carota L.) root and leaf tissues. Plant Cell Reports,27(2), 279–287.
    • (2008) Plant Cell Reports , vol.27 , Issue.2 , pp. 279-287
    • Wally, O.1    Jayaraj, J.2    Punja, Z.K.3
  • 22
    • 77952419767 scopus 로고    scopus 로고
    • Putative storage root specific promoters from cassava and yam: Cloning and evaluation in transgenic carrots as a model system
    • COI: 1:CAS:528:DC%2BC3cXmtV2jur4%3D
    • Arango, J., Salazar, B., Welsch, R., Sarmiento, F., Beyer, P., & Al-Babili, S. (2010). Putative storage root specific promoters from cassava and yam: Cloning and evaluation in transgenic carrots as a model system. Plant Cell Reports,29(6), 651–659.
    • (2010) Plant Cell Reports , vol.29 , Issue.6 , pp. 651-659
    • Arango, J.1    Salazar, B.2    Welsch, R.3    Sarmiento, F.4    Beyer, P.5    Al-Babili, S.6
  • 23
    • 0020075619 scopus 로고
    • Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells
    • COI: 1:CAS:528:DyaL38XitFChtbw%3D
    • Chilton, M. D., Tepfer, D. A., Petit, A., David, C., Casse-Delbart, F., & Tempé, J. (1982). Agrobacterium rhizogenes inserts T-DNA into the genomes of the host plant root cells. Nature,295, 432–434.
    • (1982) Nature , vol.295 , pp. 432-434
    • Chilton, M.D.1    Tepfer, D.A.2    Petit, A.3    David, C.4    Casse-Delbart, F.5    Tempé, J.6
  • 25
    • 4444336532 scopus 로고    scopus 로고
    • Plastid-expressed betaine aldehyde dehydrogenase gene in carrot cultured cells, roots, and leaves confers enhanced salt tolerance
    • COI: 1:CAS:528:DC%2BD2cXnvFOqsrc%3D
    • Kumar, S., Dhingra, A., & Daniell, H. (2004). Plastid-expressed betaine aldehyde dehydrogenase gene in carrot cultured cells, roots, and leaves confers enhanced salt tolerance. Plant Physiology,136(1), 2843–2854.
    • (2004) Plant Physiology , vol.136 , Issue.1 , pp. 2843-2854
    • Kumar, S.1    Dhingra, A.2    Daniell, H.3
  • 26
    • 0028883136 scopus 로고
    • Enzyme therapy in type 1 Gaucher disease: Comparative efficacy of mannose-terminated glucocerebrosidase from natural and recombinant sources
    • COI: 1:STN:280:DyaK2M%2FnslaisA%3D%3D
    • Grabowski, G. A., Barton, N. W., Pastores, G., Dambrosia, J. M., Banerjee, T. K., McKee, M. A., et al. (1995). Enzyme therapy in type 1 Gaucher disease: Comparative efficacy of mannose-terminated glucocerebrosidase from natural and recombinant sources. Annals of Internal Medicine,122, 33–39.
    • (1995) Annals of Internal Medicine , vol.122 , pp. 33-39
    • Grabowski, G.A.1    Barton, N.W.2    Pastores, G.3    Dambrosia, J.M.4    Banerjee, T.K.5    McKee, M.A.6
  • 27
    • 84866041577 scopus 로고    scopus 로고
    • Velaglucerase alfa in the treatment of Gaucher disease type 1
    • COI: 1:CAS:528:DC%2BC3MXjvVKgt7s%3D
    • Burrow, T. A., & Grabowski, G. A. (2011). Velaglucerase alfa in the treatment of Gaucher disease type 1. Clinical Investigation (London),1, 285–293.
    • (2011) Clinical Investigation (London) , vol.1 , pp. 285-293
    • Burrow, T.A.1    Grabowski, G.A.2
  • 28
    • 84899630021 scopus 로고    scopus 로고
    • Taliglucerase alfa: An enzyme replacement therapy using plant cell expression technology
    • COI: 1:CAS:528:DC%2BC2cXkt1Wjs7Y%3D
    • Grabowski, G. A., Golembo, M., & Shaaltiel, Y. (2014). Taliglucerase alfa: An enzyme replacement therapy using plant cell expression technology. Molecular Genetics and Metabolism,112(1), 1–8.
    • (2014) Molecular Genetics and Metabolism , vol.112 , Issue.1 , pp. 1-8
    • Grabowski, G.A.1    Golembo, M.2    Shaaltiel, Y.3
  • 29
    • 84908116847 scopus 로고    scopus 로고
    • A Phase 3, multicenter, open-label, switchover trial to assess the safety and efficacy of Taliglucerase alfa, a plant cell-expressed recombinant human glucocerebrosidase, in adult and pediatric patients with Gaucher disease previously treated with imiglucerase
    • COI: 1:CAS:528:DC%2BC2cXhtVaktL7F
    • Pastores, G. M., Petakov, M., & Giraldo, P. (2014). A Phase 3, multicenter, open-label, switchover trial to assess the safety and efficacy of Taliglucerase alfa, a plant cell-expressed recombinant human glucocerebrosidase, in adult and pediatric patients with Gaucher disease previously treated with imiglucerase. Blood Cells, Molecules, & Diseases,53(4), 253–260.
    • (2014) Blood Cells, Molecules, & Diseases , vol.53 , Issue.4 , pp. 253-260
    • Pastores, G.M.1    Petakov, M.2    Giraldo, P.3
  • 31
    • 84923771497 scopus 로고    scopus 로고
    • Protalix. Retrieved October, 2014 from.
    • Protalix. Retrieved October, 2014 from http://www.protalix.com/development-pipeline/overview-development-pipeline.asp.
  • 32
    • 84923826759 scopus 로고    scopus 로고
    • Protalix. Retrieved October, 2014 from.
    • Protalix. Retrieved October, 2014 from http://www.protalix.com/development-pipeline/prx-112-oral-gaucher-disease.asp.
  • 34
    • 84923785612 scopus 로고    scopus 로고
    • Protalix. Retrieved October, 2014 from.
    • Protalix. Retrieved October, 2014 from http://www.protalix.com/resources/DDW-2014-Poster-TNF.pdf.
  • 35
    • 84901370511 scopus 로고    scopus 로고
    • Fabry nephropathy: A review—How can we optimize the management of Fabry nephropathy?
    • Waldek, S., & Feriozzi, S. (2014). Fabry nephropathy: A review—How can we optimize the management of Fabry nephropathy? BMC Nephrology,15, 72.
    • (2014) BMC Nephrology , vol.15 , pp. 72
    • Waldek, S.1    Feriozzi, S.2
  • 36
    • 84921653204 scopus 로고    scopus 로고
    • Characterization of a chemically modified plant cell culture expressed human α-Galactosidase—A enzyme for treatment of Fabry disease
    • Kizhner, T., Azulay, Y., Hainrichson, M., Tekoah, Y., Arvatz, G., Shulman, A., et al. (2014). Characterization of a chemically modified plant cell culture expressed human α-Galactosidase—A enzyme for treatment of Fabry disease. Molecular Genetics and Metabolism,. doi:10.1016/j.ymgme.2014.08.002.
    • (2014) Molecular Genetics and Metabolism
    • Kizhner, T.1    Azulay, Y.2    Hainrichson, M.3    Tekoah, Y.4    Arvatz, G.5    Shulman, A.6
  • 38
    • 84923788788 scopus 로고    scopus 로고
    • Protalix. Retrieved October, 2014 from.
    • Protalix. Retrieved October, 2014 from http://www.protalix.com/development-pipeline/prx-110-dnase.asp.
  • 40
    • 84923782496 scopus 로고    scopus 로고
    • World Health Organization (WHO). Retrieved September, 2014 from.
    • World Health Organization (WHO). Retrieved September, 2014 from http://www.who.int/immunization/diseases/measles/en/index.html.
  • 41
    • 0033485608 scopus 로고    scopus 로고
    • Modeling the impact of subclinical measles transmission in vaccinated populations with waning immunity
    • COI: 1:STN:280:DC%2BD3c%2FltlejtA%3D%3D
    • Mossong, J., Nokes, D. J., Edmunds, W. J., Cox, M., Ratnam, S., & Muller, C. (1999). Modeling the impact of subclinical measles transmission in vaccinated populations with waning immunity. American Journal of Epidemiology,150, 1238–1249.
    • (1999) American Journal of Epidemiology , vol.150 , pp. 1238-1249
    • Mossong, J.1    Nokes, D.J.2    Edmunds, W.J.3    Cox, M.4    Ratnam, S.5    Muller, C.6
  • 43
    • 0026058342 scopus 로고
    • Measles virus: both hemagglutinin and fusion glycoproteins are required for fusion
    • COI: 1:CAS:528:DyaK3MXhtl2msbg%3D
    • Wild, T. F., Malvoisin, E., & Buckland, R. (1991). Measles virus: both hemagglutinin and fusion glycoproteins are required for fusion. The Journal of General Virology,72, 439–442.
    • (1991) The Journal of General Virology , vol.72 , pp. 439-442
    • Wild, T.F.1    Malvoisin, E.2    Buckland, R.3
  • 45
    • 0021952671 scopus 로고
    • Correlation between epitopes on hemagglutinin of measles virus and biological activities: Passive protection by monoclonal antibodies is related to their hemagglutination inhibiting activity
    • COI: 1:CAS:528:DyaL2MXktlGrsrg%3D
    • Giraudon, P., & Wild, F. (1985). Correlation between epitopes on hemagglutinin of measles virus and biological activities: Passive protection by monoclonal antibodies is related to their hemagglutination inhibiting activity. Virology,144, 46–58.
    • (1985) Virology , vol.144 , pp. 46-58
    • Giraudon, P.1    Wild, F.2
  • 46
    • 0034726403 scopus 로고    scopus 로고
    • Differential antigenicity of recombinant polyepitope-antigens based on loop- and helix-forming B and T cell epitopes
    • COI: 1:CAS:528:DC%2BD3cXmtlGks7s%3D
    • Theisen, D. M., Bouche, F. B., El Kasmi, K. C., von der Ahe, I., Ammerlaan, W., Demotz, S., & Muller, C. P. (2000). Differential antigenicity of recombinant polyepitope-antigens based on loop- and helix-forming B and T cell epitopes. Journal of Immunological Methods,242, 145–157.
    • (2000) Journal of Immunological Methods , vol.242 , pp. 145-157
    • Theisen, D.M.1    Bouche, F.B.2    El Kasmi, K.C.3    von der Ahe, I.4    Ammerlaan, W.5    Demotz, S.6    Muller, C.P.7
  • 47
    • 0037449108 scopus 로고    scopus 로고
    • Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant: A novel antigen to protect against measles
    • Theisen, D. M., Bouche, F. B., El Kasmi, K. C., von der Ahe, I., Ammerlaan, W., Demotz, S., et al. (2003). Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant: A novel antigen to protect against measles. Vaccine,21(17–18), 2065–2072.
    • (2003) Vaccine , vol.21 , Issue.17-18 , pp. 2065-2072
    • Theisen, D.M.1    Bouche, F.B.2    El Kasmi, K.C.3    von der Ahe, I.4    Ammerlaan, W.5    Demotz, S.6
  • 48
    • 14844336879 scopus 로고    scopus 로고
    • Induction of broadly neutralizing antibodies against measles virus mutants using a polyepitope vaccine strategy
    • COI: 1:CAS:528:DC%2BD2MXitVCgsLk%3D
    • Bouche, F. B., Steinmetz, A., Yanagi, Y., & Muller, C. P. (2005). Induction of broadly neutralizing antibodies against measles virus mutants using a polyepitope vaccine strategy. Vaccine,23(17–18), 2074–2077.
    • (2005) Vaccine , vol.23 , Issue.17-18 , pp. 2074-2077
    • Bouche, F.B.1    Steinmetz, A.2    Yanagi, Y.3    Muller, C.P.4
  • 49
    • 84923805224 scopus 로고    scopus 로고
    • World Health Organization (WHO). Retrieved September, 2014 from.
    • World Health Organization (WHO). Retrieved September, 2014 from http://www.who.int/mediacentre/factsheets/fs204/en/index.html.
  • 50
    • 14744283794 scopus 로고    scopus 로고
    • Virus-like particle expression and assembly in plants: Hepatitis B and Norwalk viruses
    • COI: 1:CAS:528:DC%2BD2MXhsleisrc%3D
    • Huang, Z., Elkin, G., Maloney, B. J., Beuhner, N., Arntzen, C. J., Thanavala, Y., & Mason, H. S. (2005). Virus-like particle expression and assembly in plants: Hepatitis B and Norwalk viruses. Vaccine,23(15), 1851–1858.
    • (2005) Vaccine , vol.23 , Issue.15 , pp. 1851-1858
    • Huang, Z.1    Elkin, G.2    Maloney, B.J.3    Beuhner, N.4    Arntzen, C.J.5    Thanavala, Y.6    Mason, H.S.7
  • 51
    • 33845189147 scopus 로고    scopus 로고
    • Oral immunogenicity of potato-derived HBsAg middle protein in BALB/c mice
    • COI: 1:CAS:528:DC%2BD28Xht12ru7vN
    • Youm, J. W., Won, Y. S., Jeon, J. H., Ryu, C. J., Choi, Y. K., Kim, H. C., et al. (2007). Oral immunogenicity of potato-derived HBsAg middle protein in BALB/c mice. Vaccine,25(3), 577–584.
    • (2007) Vaccine , vol.25 , Issue.3 , pp. 577-584
    • Youm, J.W.1    Won, Y.S.2    Jeon, J.H.3    Ryu, C.J.4    Choi, Y.K.5    Kim, H.C.6
  • 52
    • 34248376548 scopus 로고    scopus 로고
    • Expression of the human hepatitis B virus large surface antigen gene in transgenic tomato plants
    • COI: 1:CAS:528:DC%2BD2sXkvVSkt70%3D
    • Lou, X. M., Yao, Q. H., Zhang, Z., Peng, R. H., Xiong, A. S., & Wang, H. K. (2007). Expression of the human hepatitis B virus large surface antigen gene in transgenic tomato plants. Clinical and Vaccine Immunology,14(4), 464–469.
    • (2007) Clinical and Vaccine Immunology , vol.14 , Issue.4 , pp. 464-469
    • Lou, X.M.1    Yao, Q.H.2    Zhang, Z.3    Peng, R.H.4    Xiong, A.S.5    Wang, H.K.6
  • 54
    • 84923814773 scopus 로고    scopus 로고
    • Antibody B cell responses in HIV-1 infection
    • Mouquet, H. (2014). Antibody B cell responses in HIV-1 infection. Trends in Immunology,. doi:10.1016/j.it.2014.08.007.
    • (2014) Trends in Immunology
    • Mouquet, H.1
  • 55
    • 63649152546 scopus 로고    scopus 로고
    • Production of the p24 capsid protein from HIV-1 subtype C in Arabidopsis thaliana and Daucus carota using an endoplasmic reticulum-directing SEKDEL sequence in protein expression constructs
    • COI: 1:CAS:528:DC%2BD1MXksVCgsrc%3D
    • Lindh, I., Wallin, A., Kalbina, I., Sävenstrand, H., Engström, P., Andersson, S., & Strid, A. (2009). Production of the p24 capsid protein from HIV-1 subtype C in Arabidopsis thaliana and Daucus carota using an endoplasmic reticulum-directing SEKDEL sequence in protein expression constructs. Protein Expression and Purification,66(1), 46–51.
    • (2009) Protein Expression and Purification , vol.66 , Issue.1 , pp. 46-51
    • Lindh, I.1    Wallin, A.2    Kalbina, I.3    Sävenstrand, H.4    Engström, P.5    Andersson, S.6    Strid, A.7
  • 56
    • 84923775928 scopus 로고    scopus 로고
    • Weekly Epidemiological Record (WER) (Vol. 79, pp. 301–308). Retrieved October, 2014 from.
    • Weekly Epidemiological Record (WER) (Vol. 79, pp. 301–308). Retrieved October, 2014 from http://www.who.int/wer.
  • 57
    • 84923806982 scopus 로고    scopus 로고
    • Center for Disease Control and Prevention (CDCP). Retrieved October, 2014 from.
    • Center for Disease Control and Prevention (CDCP). Retrieved October, 2014 from http://www.bt.cdc.gov/training/historyofbt/index.asp.
  • 58
    • 0033605364 scopus 로고    scopus 로고
    • The looming threat of bioterrorism
    • COI: 1:CAS:528:DyaK1MXhs1enurk%3D
    • Henderson, D. A. (1999). The looming threat of bioterrorism. Science,283, 1279–1282.
    • (1999) Science , vol.283 , pp. 1279-1282
    • Henderson, D.A.1
  • 59
    • 0036182734 scopus 로고    scopus 로고
    • Role of fraction 1 of Yersinia pestis in inhibition of phagocytosis
    • COI: 1:CAS:528:DC%2BD38XhsFSlsbY%3D
    • Du, Y. D., Rosqvist, R., & Forsberg, A. (2002). Role of fraction 1 of Yersinia pestis in inhibition of phagocytosis. Infection and Immunity,70, 1453–1460.
    • (2002) Infection and Immunity , vol.70 , pp. 1453-1460
    • Du, Y.D.1    Rosqvist, R.2    Forsberg, A.3
  • 60
    • 0029021978 scopus 로고
    • Suppression of cytokines in mice by protein A-V fusion peptide and restoration of synthesis by active immunization
    • COI: 1:CAS:528:DyaK2MXntFyqt7Y%3D
    • Nakajima, R., Motin, V. L., & Brubaker, R. R. (1995). Suppression of cytokines in mice by protein A-V fusion peptide and restoration of synthesis by active immunization. Infection and Immunity,63, 3021–3029.
    • (1995) Infection and Immunity , vol.63 , pp. 3021-3029
    • Nakajima, R.1    Motin, V.L.2    Brubaker, R.R.3
  • 61
    • 78650001639 scopus 로고    scopus 로고
    • Transgenic carrot tap roots expressing an immunogenic F1-V fusion protein from Yersinia pestis are immunogenic in mice
    • COI: 1:CAS:528:DC%2BC3cXhsF2jurjM
    • Rosales-Mendoza, S., Soria-Guerra, R. E., Moreno-Fierros, L., Han, Y., Alpuche-Solís, A. G., & Korban, S. S. (2011). Transgenic carrot tap roots expressing an immunogenic F1-V fusion protein from Yersinia pestis are immunogenic in mice. Journal of Plant Physiology,168(2), 174–180.
    • (2011) Journal of Plant Physiology , vol.168 , Issue.2 , pp. 174-180
    • Rosales-Mendoza, S.1    Soria-Guerra, R.E.2    Moreno-Fierros, L.3    Han, Y.4    Alpuche-Solís, A.G.5    Korban, S.S.6
  • 62
    • 84920145467 scopus 로고    scopus 로고
    • Immunity, immunopathology, and human vaccine development against sexually transmitted Chlamydia trachomatis
    • Rey-Ladino, J., Ross, A. G., & Cripps, A. W. (2014). Immunity, immunopathology, and human vaccine development against sexually transmitted Chlamydia trachomatis. Human Vaccines & Immunotherapeutics,10(9), 2664–2673.
    • (2014) Human Vaccines & Immunotherapeutics , vol.10 , Issue.9 , pp. 2664-2673
    • Rey-Ladino, J.1    Ross, A.G.2    Cripps, A.W.3
  • 63
    • 80052854898 scopus 로고    scopus 로고
    • A novel chimeric MOMP antigen expressed in Escherichia coli, Arabidopsis thaliana, and Daucus carota as a potential Chlamydia trachomatis vaccine candidate
    • COI: 1:CAS:528:DC%2BC3MXhtlejtLrJ
    • Kalbina, I., Wallin, A., Lindh, I., Engström, P., Andersson, S., & Strid, K. (2011). A novel chimeric MOMP antigen expressed in Escherichia coli, Arabidopsis thaliana, and Daucus carota as a potential Chlamydia trachomatis vaccine candidate. Protein Expression and Purification,80(2), 194–202.
    • (2011) Protein Expression and Purification , vol.80 , Issue.2 , pp. 194-202
    • Kalbina, I.1    Wallin, A.2    Lindh, I.3    Engström, P.4    Andersson, S.5    Strid, K.6
  • 64
    • 84923796266 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention (CDCP). Retrieved September, 2014 from.
    • Centers for Disease Control and Prevention (CDCP). Retrieved September, 2014 from http://www.cdc.gov/tb/topic/globaltb/default.htm.
  • 65
    • 84923802260 scopus 로고    scopus 로고
    • World Health Organization (WHO). Retrieved September, 2014 from.
    • World Health Organization (WHO). Retrieved September, 2014 from http://www.who.int/tb/vaccinesfaqs/en/.
  • 68
    • 72849149644 scopus 로고    scopus 로고
    • Bordetella pertussis and pertussis vaccines
    • Guiso, N. (2009). Bordetella pertussis and pertussis vaccines. Clinical Infectious Diseases,49(10), 1565–1569.
    • (2009) Clinical Infectious Diseases , vol.49 , Issue.10 , pp. 1565-1569
    • Guiso, N.1
  • 69
    • 84923778474 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention (CDCP). Retrieved September, 2014 from.
    • Centers for Disease Control and Prevention (CDCP). Retrieved September, 2014 from http://www.cdc.gov/vaccines/pubs/pinkbook/tetanus.html.
  • 70
    • 67349203982 scopus 로고    scopus 로고
    • Generation of plant-derived recombinant DTP subunit vaccine
    • COI: 1:CAS:528:DC%2BD1MXmtlKkt7w%3D
    • Brodzik, R., Spitsin, S., Pogrebnyak, N., Tzinserling, V., & Yakovlev, A. (2009). Generation of plant-derived recombinant DTP subunit vaccine. Vaccine,27(28), 3730–3734.
    • (2009) Vaccine , vol.27 , Issue.28 , pp. 3730-3734
    • Brodzik, R.1    Spitsin, S.2    Pogrebnyak, N.3    Tzinserling, V.4    Yakovlev, A.5
  • 71
    • 84923829764 scopus 로고    scopus 로고
    • World Health Organization (WHO). Retrieved October 2014 from.
    • World Health Organization (WHO). Retrieved October 2014 from http://www.who.int/mediacentre/factsheets/fs204/en/index.html.
  • 72
    • 12144281678 scopus 로고    scopus 로고
    • Prevalence of enterotoxigenic Escherichia coli-associated diarrhoea and carrier state in the developing world
    • Wenneras, C., & Erling, V. (2004). Prevalence of enterotoxigenic Escherichia coli-associated diarrhoea and carrier state in the developing world. Journal of Health, Population, and Nutrition,22(4), 370–382.
    • (2004) Journal of Health, Population, and Nutrition , vol.22 , Issue.4 , pp. 370-382
    • Wenneras, C.1    Erling, V.2
  • 73
    • 0025804295 scopus 로고
    • Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli
    • COI: 1:CAS:528:DyaK3MXksVCmsbc%3D
    • Sixma, T. K., Pronk, S. E., Kalk, K. H., Wartna, E. S., van Zanten, B. A., Witholt, B., & Hol, W. G. (1991). Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli. Nature,351, 371–377.
    • (1991) Nature , vol.351 , pp. 371-377
    • Sixma, T.K.1    Pronk, S.E.2    Kalk, K.H.3    Wartna, E.S.4    van Zanten, B.A.5    Witholt, B.6    Hol, W.G.7
  • 74
    • 84923815367 scopus 로고    scopus 로고
    • Killed oral cholera vaccines: History, development and implementation challenges
    • COI: 1:CAS:528:DC%2BC2cXhvFKnsbzO
    • Lopez, A. L., Gonzales, M. L., Aldaba, J. G., & Nair, G. B. (2014). Killed oral cholera vaccines: History, development and implementation challenges. Therapeutic Advances in Vaccines,2(5), 123–136.
    • (2014) Therapeutic Advances in Vaccines , vol.2 , Issue.5 , pp. 123-136
    • Lopez, A.L.1    Gonzales, M.L.2    Aldaba, J.G.3    Nair, G.B.4
  • 75
    • 36949021571 scopus 로고    scopus 로고
    • Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge
    • COI: 1:CAS:528:DC%2BD2sXhsVSls7jE
    • Rosales-Mendoza, S., Soria-Guerra, R. E., López-Revilla, R., Moreno-Fierros, L., & Alpuche-Solís, A. (2008). Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge. Plant Cell Reports,27(1), 79–84.
    • (2008) Plant Cell Reports , vol.27 , Issue.1 , pp. 79-84
    • Rosales-Mendoza, S.1    Soria-Guerra, R.E.2    López-Revilla, R.3    Moreno-Fierros, L.4    Alpuche-Solís, A.5
  • 76
    • 84909619308 scopus 로고    scopus 로고
    • Helicobacter pylori vaccination: Is there a path to protection?
    • COI: 1:CAS:528:DC%2BC2cXhvFSksr7J
    • Anderl, F., & Gerhard, M. (2014). Helicobacter pylori vaccination: Is there a path to protection? World Journal of Gastroenterology,20(34), 11939–11949.
    • (2014) World Journal of Gastroenterology , vol.20 , Issue.34 , pp. 11939-11949
    • Anderl, F.1    Gerhard, M.2
  • 77
    • 0033000163 scopus 로고    scopus 로고
    • Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults
    • COI: 1:STN:280:DyaK1M7pt1Gnuw%3D%3D
    • Michetti, P., Kreiss, C., Kotloff, K. L., Porta, N., Blanco, J. L., Bachmann, D., et al. (1999). Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults. Gastroenterology,116(4), 804–812.
    • (1999) Gastroenterology , vol.116 , Issue.4 , pp. 804-812
    • Michetti, P.1    Kreiss, C.2    Kotloff, K.L.3    Porta, N.4    Blanco, J.L.5    Bachmann, D.6
  • 78
    • 70449718830 scopus 로고    scopus 로고
    • Oral immunogenicity and protective efficacy in mice of a carrot-derived vaccine candidate expressing UreB subunit against Helicobacter pylori
    • COI: 1:CAS:528:DC%2BD1MXhsVaisrzI
    • Zhang, H., Liu, M., Li, Y., He, H., Yang, G., & Zheng, C. (2010). Oral immunogenicity and protective efficacy in mice of a carrot-derived vaccine candidate expressing UreB subunit against Helicobacter pylori. Protein Expression and Purification,69(2), 127–131.
    • (2010) Protein Expression and Purification , vol.69 , Issue.2 , pp. 127-131
    • Zhang, H.1    Liu, M.2    Li, Y.3    He, H.4    Yang, G.5    Zheng, C.6
  • 79
    • 84859099891 scopus 로고    scopus 로고
    • A sweet potato SRD1 promoter confers strong root-, taproot-, and tuber-specific expression in Arabidopsis, carrot, and potato
    • COI: 1:CAS:528:DC%2BC38XksVKrs7c%3D
    • Noh, S. A., Lee, H. S., Huh, G. H., Oh, M. J., Paek, K. H., Shin, J. S., & Bae, J. M. (2012). A sweet potato SRD1 promoter confers strong root-, taproot-, and tuber-specific expression in Arabidopsis, carrot, and potato. Transgenic Research,21(2), 265–278.
    • (2012) Transgenic Research , vol.21 , Issue.2 , pp. 265-278
    • Noh, S.A.1    Lee, H.S.2    Huh, G.H.3    Oh, M.J.4    Paek, K.H.5    Shin, J.S.6    Bae, J.M.7
  • 81
    • 84925511517 scopus 로고    scopus 로고
    • Current status of viral expression systems in plants and perspectives for oral vaccines development. Plant Molecular Biology
    • Salazar-González, J. A., Bañuelos-Hernández, B., & Rosales-Mendoza, S. (2015). Current status of viral expression systems in plants and perspectives for oral vaccines development. Plant Molecular Biology. doi:10.1007/s11103-014-0279-5.
    • (2015) doi:10.1007/s11103-014-0279-5
    • Salazar-González, J.A.1    Bañuelos-Hernández, B.2    Rosales-Mendoza, S.3
  • 82
    • 84881332032 scopus 로고    scopus 로고
    • Hybrid viral vectors for vaccine and antibody production in plants
    • COI: 1:CAS:528:DC%2BC3sXhsVylt7bF
    • Yusibov, V., Streatfield, S. J., Kushnir, N., Roy, G., & Padmanaban, A. (2013). Hybrid viral vectors for vaccine and antibody production in plants. Current Pharmaceutical Design,19(31), 5574–5586.
    • (2013) Current Pharmaceutical Design , vol.19 , Issue.31 , pp. 5574-5586
    • Yusibov, V.1    Streatfield, S.J.2    Kushnir, N.3    Roy, G.4    Padmanaban, A.5
  • 83
    • 84929870155 scopus 로고    scopus 로고
    • Seed-based expression strategies. In: S. Rosales Mendoza (Ed.), Genetically engineered plants as a source of vaccines against wide spread diseases—An integrated view. New York: Springer
    • Orellana-Escobedo, L., Korban, S. S., & Rosales-Mendoza, S. (2014). Seed-based expression strategies. In: S. Rosales Mendoza (Ed.), Genetically engineered plants as a source of vaccines against wide spread diseases—An integrated view. New York: Springer. ISBN 978-1-4939-0850-9.
    • (2014) ISBN 978-1-4939-0850-9
    • Orellana-Escobedo, L.1    Korban, S.S.2    Rosales-Mendoza, S.3
  • 84
    • 0010386986 scopus 로고
    • Carrot (Daucus carota) hypocotyls transformation using Agrobacterium tumefaciens
    • COI: 1:CAS:528:DyaL1MXmt1Knsrw%3D
    • Thomas, J., Guiltinan, M., Bustos, S., Thomas, T., & Nessler, C. (1989). Carrot (Daucus carota) hypocotyls transformation using Agrobacterium tumefaciens. Plant Cell Reports,8, 354–357.
    • (1989) Plant Cell Reports , vol.8 , pp. 354-357
    • Thomas, J.1    Guiltinan, M.2    Bustos, S.3    Thomas, T.4    Nessler, C.5
  • 85
    • 0000566540 scopus 로고    scopus 로고
    • A rapid method for transformation of carrot (Daucus carota L.) by using direct somatic embryogenesis
    • COI: 1:CAS:528:DyaK1MXisVekuro%3D
    • Tokuji, Y., & Fukuda, H. (1999). A rapid method for transformation of carrot (Daucus carota L.) by using direct somatic embryogenesis. Bioscience, Biotechnology, and Biochemistry,63, 519–523.
    • (1999) Bioscience, Biotechnology, and Biochemistry , vol.63 , pp. 519-523
    • Tokuji, Y.1    Fukuda, H.2
  • 86
    • 38249026387 scopus 로고
    • A simple, efficient method for the Agrobacterium-mediated transformation of carrot callus cells
    • COI: 1:CAS:528:DyaL1MXit1Kmu74%3D
    • Wurtele, E., & Bulka, K. (1989). A simple, efficient method for the Agrobacterium-mediated transformation of carrot callus cells. Plant Science,61, 253–262.
    • (1989) Plant Science , vol.61 , pp. 253-262
    • Wurtele, E.1    Bulka, K.2
  • 87
    • 0036320033 scopus 로고    scopus 로고
    • Factors affecting transformation of cell cultures from three dicotyledoneous pigment- producing species using microprojectile bombardment
    • COI: 1:CAS:528:DC%2BD38XkvVaitr4%3D
    • Deroles, S., Smith, M., & Lee, C. (2002). Factors affecting transformation of cell cultures from three dicotyledoneous pigment- producing species using microprojectile bombardment. Plant Cell, Tissue and Organ Culture,70, 69–76.
    • (2002) Plant Cell, Tissue and Organ Culture , vol.70 , pp. 69-76
    • Deroles, S.1    Smith, M.2    Lee, C.3
  • 88
    • 76049118449 scopus 로고    scopus 로고
    • Expression of rabies virus G protein in carrots (Daucus carota)
    • Rojas, E., Loza, E., Olivera, M., & Gomez, M. (2009). Expression of rabies virus G protein in carrots (Daucus carota). Transgenic Research,18, 911–919.
    • (2009) Transgenic Research , vol.18 , pp. 911-919
    • Rojas, E.1    Loza, E.2    Olivera, M.3    Gomez, M.4
  • 89
    • 84901997898 scopus 로고    scopus 로고
    • Overexpression of a tobacco osmotin gene in carrot (Daucus carota L.) enhances drought tolerance
    • COI: 1:CAS:528:DC%2BC2cXpsVert7k%3D
    • Annon, A., Rathore, K., & Crosby, K. (2014). Overexpression of a tobacco osmotin gene in carrot (Daucus carota L.) enhances drought tolerance. In Vitro Cellular & Developmental Biology-Plant,50, 299–306.
    • (2014) In Vitro Cellular & Developmental Biology-Plant , vol.50 , pp. 299-306
    • Annon, A.1    Rathore, K.2    Crosby, K.3
  • 90
    • 0343488184 scopus 로고
    • Expression from heterologous promoters in electroporated carrot protoplasts
    • COI: 1:CAS:528:DyaL2sXktlCiur8%3D
    • Boston, R., Becwar, M., Ryan, R., Goldsbrough, P., Larkings, B., & Hodges, (1987). Expression from heterologous promoters in electroporated carrot protoplasts. Plant Physiology,83, 742–746.
    • (1987) Plant Physiology , vol.83 , pp. 742-746
    • Boston, R.1    Becwar, M.2    Ryan, R.3    Goldsbrough, P.4    Larkings, B.5    Hodges, &.6
  • 91
    • 0030449390 scopus 로고    scopus 로고
    • A new protoplast culture system in Daucus carota L. and its application for mutant selection and transformation
    • COI: 1:STN:280:DC%2BC2c7gt1Wqtw%3D%3D
    • Dirks, R., & Sidorov, Tulmans C. (1996). A new protoplast culture system in Daucus carota L. and its application for mutant selection and transformation. Theoretical Applied Genetics,93, 809–815.
    • (1996) Theoretical Applied Genetics , vol.93 , pp. 809-815
    • Dirks, R.1    Sidorov, T.C.2
  • 92
    • 0010641336 scopus 로고
    • Transformation of carrot tissues derived from embryogenic suspensión cells: A useful model system for gene expression studies in plants
    • COI: 1:CAS:528:DyaL2sXitVylt7s%3D
    • Scott, R., & Draper, J. (1987). Transformation of carrot tissues derived from embryogenic suspensión cells: A useful model system for gene expression studies in plants. Plant Molecular Biology,8, 265–274.
    • (1987) Plant Molecular Biology , vol.8 , pp. 265-274
    • Scott, R.1    Draper, J.2
  • 93
    • 0030473375 scopus 로고    scopus 로고
    • Introduction and expression of chitinase encoding genes in carrot following Agrobacterium-mediated transformation
    • COI: 1:CAS:528:DyaK28XmsVams7s%3D
    • Gilbert, M., Zhang, Y., & Punja, Z. (1996). Introduction and expression of chitinase encoding genes in carrot following Agrobacterium-mediated transformation. In Vitro Cellular & Developmental Biology-Plant,32, 171–178.
    • (1996) In Vitro Cellular & Developmental Biology-Plant , vol.32 , pp. 171-178
    • Gilbert, M.1    Zhang, Y.2    Punja, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.