Metabolite markers of incident CKD risk

Clinical Journal of the American Society of Nephrology

Volumn 9, Issue 8, 2014, Pages 1344-1346

  Rhee, Eugene P ^a,b   Feldman, Harold I ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1, 5 ANHYDROSORBITOL; BIOLOGICAL MARKER; CHOLINE; CITRULLINE; GLUCOSE; GLUTATHIONE; KYNURENIC ACID; KYNURENINE; PYROGLUTAMIC ACID; UNCLASSIFIED DRUG;

CHRONIC KIDNEY DISEASE; DISEASE COURSE; EDITORIAL; FOLLOW UP; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FUNCTION; KIDNEY INJURY; METABOLITE; METABOLOMICS; NONHUMAN; PATHOGENESIS; RISK FACTOR; TRYPTOPHAN METABOLISM; AFRICAN AMERICAN; BLOOD; CHRONIC KIDNEY FAILURE; ETHNOLOGY; FEMALE; MALE;

AFRICAN AMERICANS; BIOMARKERS; FEMALE; HUMANS; MALE; METABOLOMICS; RENAL INSUFFICIENCY, CHRONIC;

EID: 84923799918     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.05910614     Document Type: Editorial

References (16)

1. Rhee EP, Gerszten RE: Metabolomics and cardiovascular biomarker discovery. Clin Chem 58: 139–147, 2012
2. Goek ON, Prehn C, Sekula P, Römisch-Margl W, Döring A, Gieger C, Heier M, Koenig W, Wang-Sattler R, Illig T, Suhre K, Adamski J, Köttgen A, Meisinger C: Metabolites associate with kidney function decline and incident chronic kidney disease in the general population. Nephrol Dial Transplant 28: 2131–2138, 2013
3. Rhee EP, Clish CB, Ghorbani A, Larson MG, Elmariah S, McCabe E, Yang Q, Cheng S, Pierce K, Deik A, Souza AL, Farrell L, Domos C, Yeh RW, Palacios I, Rosenfield K, Vasan RS, Florez JC, Wang TJ, Fox CS, Gerszten RE: A combined epidemiologic and metabolomic approach improves CKD prediction. J Am Soc Nephrol 24: 1330–1338, 2013
4. Mohib K, Wang S, Guan Q, Mellor AL, Sun H, Du C, Jevnikar AM: Indoleamine 2,3-dioxygenase expression promotes renalischemia-reperfusion injury. Am J Physiol Renal Physiol 295: F226–F234, 2008
5. Mohib K, Guan Q, Diao H, Du C, Jevnikar AM: Proapoptotic activity of indoleamine 2,3-dioxygenase expressed in renal tubular epithelial cells. Am J Physiol Renal Physiol 293: F801–F812, 2007
6. Wang Y, Liu H, McKenzie G, Witting PK, Stasch JP, Hahn M, Changsirivathanathamrong D, Wu BJ, Ball HJ, Thomas SR, Kapoor V, Celermajer DS, Mellor AL, Keaney JF Jr, Hunt NH, Stocker R: Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med 16: 279–285, 2010
7. Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, Ling L: Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem 281: 22021–22028, 2006
8. Yu B, Zheng Y, Nettleton JA, Alexander D, Coresh J, Boerwinkle E: Serum metabolomic profiling and incident CKD among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. Clin J Am Soc Nephrol 9: 1410–1417, 2014
9. Toyohara T, Akiyama Y, Suzuki T, Takeuchi Y, Mishima E, Tanemoto M, Momose A, Toki N, Sato H, Nakayama M, Hozawa A, Tsuji I, Ito S, Soga T, Abe T: Metabolomic profiling of uremic solutes in CKD patients. Hypertens Res 33: 944–952, 2010
10. Shah VO, Townsend RR, Feldman HI, Pappan KL, Kensicki E, Vander Jagt DL: Plasma metabolomic profiles in different stages of CKD. Clin J Am Soc Nephrol 8: 363–370, 2013
11. Goek ON, Döring A, Gieger C, Heier M, Koenig W, Prehn C, Römisch-Margl W, Wang-Sattler R, Illig T, Suhre K, Sekula P, Zhai G, Adamski J, Köttgen A, Meisinger C: Serum metabolite concentrations and decreased GFR in the general population. Am J Kidney Dis 60: 197–206, 2012
12. Duranton F, Lundin U, Gayrard N, Mischak H, Aparicio M, Mourad G, Daure`s JP, Weinberger KM, Argilés A: Plasma and urinary amino acid metabolomic profiling in patients with different levels of kidney function. Clin J Am Soc Nephrol 9: 37–45, 2014
13. Liss DB, Paden MS, Schwarz ES, Mullins ME: What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure? Clin Toxicol (Phila) 51: 817–827, 2013
14. Dungan KM: 1,5-anhydroglucitol (GlycoMark) as a marker of short-term glycemic control and glycemic excursions. Expert Rev Mol Diagn 8: 9–19, 2008
15. Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, Sinelnikov I, Krishnamurthy R, Eisner R, Gautam B, Young N, Xia J, Knox C, Dong E, Huang P, Hollander Z, Pedersen TL, Smith SR, Bamforth F, Greiner R, McManus B, Newman JW, Goodfriend T, Wishart DS: The human serum metabolome. PLoS ONE 6: e16957, 2011
16. Niewczas MA, Sirich TL, Mathew AV, Skupien J, Mohney RP, Warram JH, Smiles A, Huang X, Walker W, Byun J, Karoly ED, Kensicki EM, Berry GT, Bonventre JV, Pennathur S, Meyer TW, Krolewski AS: Uremic solutes and risk of end-stage renal disease in type 2 diabetes: Metabolomic study. Kidney Int 85: 1214–1224, 2014