Serum metabolite concentrations and decreased GFR in the general population

American Journal of Kidney Diseases

Volumn 60, Issue 2, 2012, Pages 197-206

  Goek, Oemer Necmi ^a   Döring, Angela ^b   Gieger, Christian ^b   Heier, Margit ^b   Koenig, Wolfgang ^c   Prehn, Cornelia ^b   Römisch Margl, Werner ^b   Wang Sattler, Rui ^b   Illig, Thomas ^b,d   Suhre, Karsten ^b,e,f   Sekula, Peggy ^a   Zhai, Guangju ^g,h   Adamski, Jerzy ^b,i   Köttgen, Anna ^a,j   Meisinger, Christa ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY HOSPITAL ULM   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^f UNIVERSITY OF MUNICH   (Germany)

^g KING'S COLLEGE LONDON   (United Kingdom)

^h MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

ⁱ Life and Food Science Center Weihenstephan   (Germany)

^j JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

more..

Author keywords

chronic kidney disease; estimated glomerular filtration rate; metabolites; Metabolomics

Indexed keywords

ACYLCARNITINE; CREATININE; CYSTATIN C; GLUTARYLCARNITINE; SERINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DIAGNOSTIC VALUE; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLITE; MULTIPLE LINEAR REGRESSION ANALYSIS; OBSERVATIONAL STUDY; PHENOTYPE; POPULATION RESEARCH; PREVALENCE; QUANTITATIVE ANALYSIS; SERUM FACTOR;

CARNITINE; CREATININE; CROSS-SECTIONAL STUDIES; CYSTATIN C; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY FUNCTION TESTS; MALE; METABOLOMICS; MIDDLE AGED; REFERENCE VALUES; RENAL INSUFFICIENCY, CHRONIC;

EID: 84863988304     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2012.01.014     Document Type: Article

References (36)

1. Q.L. Zhang, D. Rothenbacher Prevalence of chronic kidney disease in population-based studies: systematic review BMC Public Health 8 2008 117
2. P.B. Rehberg Studies on kidney function: the rate of filtration and reabsorption in the human kidney Biochem J 20 3 1926 447 460
3. M.E. Brosnan, J.T. Brosnan Renal arginine metabolism J Nutr 134(10) suppl 2004 2791S 2795S discussion 2796S-2797S
4. C. Bergwitz, H. Juppner Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23 Annu Rev Med 61 2010 91 104
5. R. Vanholder, R. De Smet, G. Glorieux Review on uremic toxins: classification, concentration, and interindividual variability Kidney Int 63 5 2003 1934 1943
6. W. He, F.J. Miao, D.C. Lin Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors Nature 429 6988 2004 188 193
7. C.B. Newgard, J. An, J.R. Bain A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance Cell Metab 9 4 2009 311 326
8. D.E. Weiner, H. Tighiouart, E.F. Elsayed, J.L. Griffith, D.N. Salem, A.S. Levey Uric acid and incident kidney disease in the community J Am Soc Nephrol 19 6 2008 1204 1211
9. R.P. Obermayr, C. Temml, G. Gutjahr, M. Knechtelsdorfer, R. Oberbauer, R. Klauser-Braun Elevated uric acid increases the risk for kidney disease J Am Soc Nephrol 19 12 2008 2407 2413
10. C. Zoccali, S. Bode-Boger, F. Mallamaci Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study Lancet 358 9299 2001 2113 2117
11. D. Fliser, F. Kronenberg, J.T. Kielstein Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study J Am Soc Nephrol 16 8 2005 2456 2461
12. J.K. Nicholson, J.C. Lindon Systems biology: metabonomics Nature 455 7216 2008 1054 1056
13. E. Holmes, R.L. Loo, J. Stamler Human metabolic phenotype diversity and its association with diet and blood pressure Nature 453 7193 2008 396 400
14. C.D. Kim, E.Y. Kim, H. Yoo Metabonomic analysis of serum metabolites in kidney transplant recipients with cyclosporine A- or tacrolimus-based immunosuppression Transplantation 90 7 2010 748 756
15. E.P. Rhee, A. Souza, L. Farrell Metabolite profiling identifies markers of uremia J Am Soc Nephrol 21 6 2010 1041 1051
16. T. Toyohara, Y. Akiyama, T. Suzuki Metabolomic profiling of uremic solutes in CKD patients Hypertens Res 33 9 2010 944 952
17. T. Niwa Update of uremic toxin research by mass spectrometry Mass Spectrom Rev 30 3 February 16, 2011 510 521
18. T. Illig, C. Gieger, G. Zhai A genome-wide perspective of genetic variation in human metabolism Nat Genet 42 2 2010 137 141
19. T. Andrew, D.J. Hart, H. Snieder, M. de Lange, T.D. Spector, A.J. MacGregor Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women Twin Res 4 6 2001 464 477
20. H.E. Wichmann, C. Gieger, T. Illig KORA-gen - resource for population genetics, controls and a broad spectrum of disease phenotypes Gesundheitswesen 67 suppl 1 2005 S26 S30
21. A.S. Levey, L.A. Stevens, C.H. Schmid A new equation to estimate glomerular filtration rate Ann Intern Med 150 9 2009 604 612
22. J. Coresh, B.C. Astor, G. McQuillan Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate Am J Kidney Dis 39 5 2002 920 929
23. E. Selvin, J. Manzi, L.A. Stevens Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988-1994, 1999-2004 Am J Kidney Dis 50 6 2007 918 926
24. L.A. Stevens, J. Coresh, C.H. Schmid Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD Am J Kidney Dis 51 3 2008 395 406
25. W. Römisch-Margl, C. Prehn, R. Bogumil, C. Röhring, K. Suhre, J. Adamski Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics Metabolomics 8 1 2012 133 142
26. K. Suhre, H. Wallaschofski, J. Raffler A genome-wide association study of metabolic traits in human urine Nat Genet 43 6 2011 565 569
27. S.J. Chanock, T. Manolio, M. Boehnke Replicating genotype-phenotype associations Nature 447 7145 2007 655 660
28. S.A. Laidlaw, R.L. Berg, J.D. Kopple, H. Naito, W.G. Walker, M. Walser Patterns of fasting plasma amino acid levels in chronic renal insufficiency: results from the feasibility phase of the Modification of Diet in Renal Disease Study Am J Kidney Dis 23 4 1994 504 513
29. C. Wanner, P. Schollmeyer, W.H. Horl Serum carnitine levels and carnitine esters of patients after kidney transplantation: role of immunosuppression Metabolism 37 3 1988 263 267
30. D. Fouque, S. Holt, F. Guebre-Egziabher Relationship between serum carnitine, acylcarnitines, and renal function in patients with chronic renal disease J Ren Nutr 16 2 2006 125 131
31. S.J. Mihalik, B.H. Goodpaster, D.E. Kelley Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity Obesity (Silver Spring) 18 9 2010 1695 1700
32. N.D. Vaziri, K. Norris Lipid disorders and their relevance to outcomes in chronic kidney disease Blood Purif 31 1-3 2011 189 196
33. M.J. Bennett, P. Rinaldo, A.W. Strauss Inborn errors of mitochondrial fatty acid oxidation Crit Rev Clin Lab Sci 37 1 2000 1 44
34. D.J. Dietzen, P. Rinaldo, R.J. Whitley National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: follow-up testing for metabolic disease identified by expanded newborn screening using tandem mass spectrometry; executive summary Clin Chem 55 9 2009 1615 1626
35. E. Altmaier, G. Kastenmuller, W. Romisch-Margl Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics Eur J Epidemiol 26 2 2011 145 156
36. L.A. Stevens, J. Coresh, T. Greene, A.S. Levey Assessing kidney function - measured and estimated glomerular filtration rate N Engl J Med 354 23 2006 2473 2483