Faecal levels of zonula occludens toxin in paediatric patients with crohn’s disease and their association with the intestinal microbiota

Journal of Medical Microbiology

Volumn 64, Issue 3, 2015, Pages 303-306

  Kaakoush, Nadeem O ^a   Castaño Rodríguez, Natalia ^a   Day, Andrew S ^a,b,c   Lemberg, Daniel A ^b   Leac, Steven T ^a   Mitchell, Hazel M ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b SYDNEY CHILDREN'S HOSPITAL   (Australia)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; EXOTOXIN 9; RNA 16S; UNCLASSIFIED DRUG; ZONULA OCCLUDENS TOXIN; CHOLERA TOXIN; ZONULA OCCLUDENS TOXIN, VIBRIO CHOLERAE;

ADLERCREUTZIA; ADLERCREUTZIA EQUOLIFACIENS; ADOLESCENT; CAMPYLOBACTER CONCISUS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CROHN DISEASE ACTIVITY INDEX; DIALISTER; DIALISTER INVISUS; FAECALIBACTERIUM; FAECALIBACTERIUM PRAUSNITZII; FECES MICROFLORA; FEMALE; HIGH THROUGHPUT SEQUENCING; HUMAN; INTESTINE FLORA; MALE; MICROBIAL COMMUNITY; NOTE; OSCILLOSPIRA; OSCILLOSPIRA GUILLIERMONDII; PRESCHOOL CHILD; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REMISSION; SCHOOL CHILD; CHEMISTRY; COMPLICATION; DYSBIOSIS; FECES; INTESTINE; MICROBIOLOGY; MICROFLORA; VIBRIO CHOLERAE;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHOLERA TOXIN; CROHN DISEASE; DYSBIOSIS; FECES; FEMALE; HUMANS; INTESTINES; MALE; MICROBIOTA; VIBRIO CHOLERAE;

EID: 84923701028     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.000005     Document Type: Note

References (18)

1. Bereswill, S., Plickert, R., Fischer, A., Kühl, A. A., Loddenkemper, C., Batra, A., Siegmund, B., Göbel, U. B. & Heimesaat, M. M. (2011). What you eat is what you get: novel Campylobacter models in the quadrangle relationship between nutrition, obesity, microbiota and susceptibility to infection. Eur J Microbiol Immunol (Bp) 1, 237–248.
2. Burgos-Portugal, J. A., Mitchell, H. M., Castaño-Rodríguez, N. & Kaakoush, N. O. (2014). The role of autophagy in the intracellular survival of Campylobacter concisus. FEBS Open Bio 4, 301–309.
3. Fasano, A., Fiorentini, C., Donelli, G., Uzzau, S., Kaper, J. B., Margaretten, K., Ding, X., Guandalini, S., Comstock, L. & Goldblum, S. E. (1995). Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest 96, 710–720.
4. Gerasimidis, K., Russell, R., Hansen, R., Quince, C., Loman, N., Bertz, M., Hanske, L., Blaut, M., McGrogan, P. & Edwards, C. A. (2014). Role of Faecalibacterium prausnitzii in Crohn’s Disease: friend, foe, or does not really matter? Inflamm Bowel Dis 20, E18–E19.
5. Kaakoush, N. O. & Mitchell, H. M. (2012). Campylobacter concisus–a new player in intestinal disease. Front Cell Infect Microbiol 2, 4.
6. Kaakoush, N. O., Man, S. M., Lamb, S., Raftery, M. J., Wilkins, M. R., Kovach, Z. & Mitchell, H. (2010). The secretome of Campylobacter concisus. FEBS J 277, 1606–1617.
7. Kaakoush, N. O., Deshpande, N. P., Wilkins, M. R., Raftery, M. J., Janitz, K. & Mitchell, H. (2011a). Comparative analyses of Campylobacter concisus strains reveal the genome of the reference strain BAA-1457 is not representative of the species. Gut Pathog 3, 15.
8. Kaakoush, N. O., Deshpande, N. P., Wilkins, M. R., Tan, C. G., Burgos-Portugal, J. A., Raftery, M. J., Day, A. S., Lemberg, D. A. & Mitchell, H. (2011b). The pathogenic potential of Campylobacter concisus strains associated with chronic intestinal diseases. PLoS One 6, e29045.
9. Kaakoush, N. O., Day, A. S., Huinao, K. D., Leach, S. T., Lemberg, D. A., Dowd, S. E. & Mitchell, H. M. (2012). Microbial dysbiosis in pediatric patients with Crohn’s disease. J Clin Microbiol 50, 3258–3266.
10. Kaakoush, N. O., Castaño-Rodríguez, N., Day, A. S., Lemberg, D. A., Leach, S. T. & Mitchell, H. M. (2014a). Campylobacter concisus and exotoxin 9 levels in paediatric patients with Crohn’s disease and their association with the intestinal microbiota. J Med Microbiol 63, 99–105.
11. Kaakoush, N. O., Mitchell, H. M. & Man, S. M. (2014b). Role of emerging Campylobacter species in inflammatory bowel diseases. Inflamm Bowel Dis 20, 2189–2197.
12. Kaakoush, N. O., Sodhi, N., Chenu, J. W., Cox, J. M., Riordan, S. M. & Mitchell, H. M. (2014c). The interplay between Campylobacter and Helicobacter species and other gastrointestinal microbiota of commercial broiler chickens. Gut Pathog 6, 18.
13. Man, S. M., Kaakoush, N. O., Leach, S. T., Nahidi, L., Lu, H. K., Norman, J., Day, A. S., Zhang, L. & Mitchell, H. M. (2010). Host attachment, invasion, and stimulation of proinflammatory cytokines by Campylobacter concisus and other non-Campylobacter jejuni Campylobacter species. J Infect Dis 202, 1855–1865.
14. Man, S. M., Kaakoush, N. O. & Mitchell, H. M. (2011). The role of bacteria and patternrecognition receptors in Crohn’s disease. Nat Rev Gastroenterol Hepatol 8, 152–168.
15. Maruo, T., Sakamoto, M., Ito, C., Toda, T. & Benno, Y. (2008). Adlercreutzia equolifaciens gen. nov., sp. nov., an equolproducing bacterium isolated from human faeces, and emended description of the genus Eggerthella. Int J Syst Evol Microbiol 58, 1221–1227.
16. Nielsen, H. L., Nielsen, H., Ejlertsen, T., Engberg, J., Günzel, D., Zeitz, M., Hering, N. A., Fromm, M., Schulzke, J. D. & Bücker, R. (2011). Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells. PLoS One 6, e23858.
17. Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J. J., Blugeon, S., Bridonneau, C., Furet, J. P. & other authors (2008). Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 105, 16731–16736.
18. Takagaki, A., Kato, Y. & Nanjo, F. (2014). Isolation and characterization of rat intestinal bacteria involved in biotransformation of (–)- epigallocatechin. Arch Microbiol 196, 681–695.