Effectiveness of a multifactorial intervention on preventing development of frailty in pre-frail older people: Study protocol for a randomised controlled trial

BMJ Open

Volumn 5, Issue 2, 2015, Pages

  Fairhall, Nicola ^a   Kurrle, Susan E ^b   Sherrington, Catherine ^a   Lord, Stephen R ^c   Lockwood, Keri ^b   John, Beatrice ^b   Monaghan, Noeline ^a   Howard, Kirsten ^d   Cameron, Ian D ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b Hornsby Ku Ring Gai Health Service   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARM CIRCUMFERENCE; ARTICLE; ASSESSMENT OF HUMANS; BODY MASS; CLINICAL EFFECTIVENESS; COGNITION; COST EFFECTIVENESS ANALYSIS; DAILY LIFE ACTIVITY; DIET SUPPLEMENTATION; DIETARY INTAKE; DIETITIAN; ERGONOMICS; FALLING; FEMALE; FOLLOW UP; FRAIL ELDERLY; FRAILTY PHENOTYPE SCORE; GAIT; GERIATRIC ASSESSMENT; GERIATRIC CARE; GERIATRIC DEPRESSION SCALE; GERIATRICIAN; HEALTH STATUS; HOSPITALIZATION; HUMAN; INTENTION TO TREAT ANALYSIS; LEISURE; MAJOR CLINICAL STUDY; MALE; MEAL; MINI MENTAL STATE EXAMINATION; MOOD; MULTIFACTORIAL INTERVENTION; NURSE; OCCUPATIONAL THERAPIST; OUTCOME ASSESSMENT; PATIENT REFERRAL; PHYSICAL ACTIVITY; PHYSICAL MOBILITY; PHYSICIAN; PHYSIOTHERAPIST; PRE FRAILTY; QUALITY ADJUSTED LIFE YEAR; RANDOMIZED CONTROLLED TRIAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REHABILITATION EQUIPMENT; REHABILITATION PHYSICIAN; RESISTANCE TRAINING; SHOE; SHORT PHYSICAL PERFORMANCE BATTERY; SOCIAL INTERACTION; SOCIAL WELFARE; TAI CHI; TELEPHONE INTERVIEW; AFFECT; CONTROLLED STUDY; DEMOGRAPHY; ELDERLY CARE; METHODOLOGY; PREVENTION AND CONTROL; UTILIZATION; VERY ELDERLY; WALKING DIFFICULTY;

ACCIDENTAL FALLS; AFFECT; AGED; AGED, 80 AND OVER; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HEALTH SERVICES FOR THE AGED; HUMANS; MALE; MOBILITY LIMITATION; OUTCOME ASSESSMENT (HEALTH CARE); RESEARCH DESIGN; RESIDENCE CHARACTERISTICS;

EID: 84923650925     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2014-007091     Document Type: Article

References (34)

1. Walston J, Hadley EC, Ferrucci L, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006;54:991-1001.
2. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56: M146-56.
3. Fried LP, Ferrucci L, Darer J, et al. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004;59:255-63.
4. Collard RM, Boter H, Schoevers RA, et al. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc 2012;60:1487-92.
5. Theou O, Stathokostas L, Roland KP, et al. The effectiveness of exercise interventions for the management of frailty: a systematic review. J Aging Res 2011;2011:569194.
6. Cameron ID, Fairhall N, Langron C, et al. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Med 2013;11:65.
7. Gill TM, Gahbauer EA, Allore HG, et al. Transitions between frailty states among community-living older persons. Arch Intern Med 2006;166:418-23.
8. Lang PO, Michel JP, Zekry D. Frailty syndrome: a transitional state in a dynamic process. Gerontology 2009;55:539-49.
9. Faber MJ, Bosscher RJ, Chin APMJ, et al. Effects of exercise programs on falls and mobility in frail and pre-frail older adults: a multicenter randomized controlled trial. Arch Phys Med Rehabil 2006;87:885-96.
10. Gill TM, Baker DI, Gottschalk M, et al. A program to prevent functional decline in physically frail, elderly persons who live at home. N Engl J Med 2002;347:1068-74.
11. Gillespie LD, Robertson MC, Gillespie WJ, et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2012;9:CD007146.
12. Daniel K. Wii-hab for pre-frail older adults. Rehabil Nurs 2012;37:195-201.
13. Lustosa LP, Silva JP, Coelho FM, et al. Impact of resistance exercise program on functional capacity and muscular strength of knee extensor in pre-frail community-dwelling older women: a randomized crossover trial. Rev Bras Fisioter 2011;15:318-24.
14. Coelho FM, Pereira DS, Lustosa LP, et al. Physical therapy intervention (PTI) increases plasma brain-derived neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly women. Arch Gerontol Geriatr 2012;54:415-20.
15. Fairhall N, Aggar C, Kurrle SE, et al. Frailty Intervention Trial (FIT). BMC Geriatr 2008;8:27.
16. Holtzman J, Lurie N. Causes of increasing mortality in a nursing home population. J Am Geriatr Soc 1996;44:258-64.
17. Beller EM, Gebski V, Keech AC. Randomisation in clinical trials. Med J Aust 2002;177:565-7.
18. Ko FC. The clinical care of frail, older adults. Clin Geriatr Med 2011;27:89-100.
19. rd edn. Frederick, MD: Aspen Publishers, 2000.
20. Sherrington C. Exercise which challenges balance can prevent falls in older people: meta-analysis of RCTs with meta-regression. Australian Physiotherapy Association Conference Week, Cairns, Australia, 2007.
21. Folstein MF, Folstein SE, McHugh PR. Mini-mental state. "A practical method for grading the cognitive state of patients for the clinician". J Psychiatr Res 1975;12:189-98.
22. Onder G, Penninx BW, Lapuerta P, et al. Change in physical performance over time in older women: the Women's Health and Aging Study. J Gerontol A Biol Sci Med Sci 2002;57:M289-93.
23. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994;49:M85-94.
24. Hoyl MT, Alessi CA, Harker JO, et al. Development and testing of a five-item version of the Geriatric Depression Scale. J Am Geriatr Soc 1999;47:873-8.
25. Mahoney FI, Barthel DW. Functional evaluation: the Barthel Index. Md State Med J 1965;14:61-5.
26. Haley SM, Coster WJ, Andres PL, et al. Score comparability of short forms and computerized adaptive testing: simulation study with the activity measure for post-acute care. Arch Phys Med Rehabil 2004;85:661-6.
27. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001;33:337-43.
28. Latham NK, Anderson CS, Lee A, et al. A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS). J Am Geriatr Soc 2003;51:291-9.
29. Wang R, Lagakos SW, Ware JH, et al. Statistics in medicine-reporting of subgroup analyses in clinical trials. N Engl J Med 2007;357:2189-94.
30. Lachin JM. Statistical considerations in the intent-to-treat principle. Control Clin Trials 2000;21:167-89.
31. Husereau D, Drummond M, Petrou S, et al. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) -explanation and elaboration: a report of the ISPOR Health Economic Evaluation Publication Guidelines Good Reporting Practices Task Force. Value Health 2013;16:231-50.
32. DiMatteo MR, Giordani PJ, Lepper HS, et al. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 2002;40:794-811.
33. Abellan van Kan G, Rolland Y, Houles M, et al. The assessment of frailty in older adults. Clin Geriatr Med 2010;26:275-86.
34. Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005;173:489-95.