Complementarity of variable-magnification and spectral-separation fluorescence imaging systems for noninvasive detection of metastasis and intravital detection of single cancer cells in mouse models

Anticancer Research

Volumn 35, Issue 2, 2015, Pages 661-667

  Zhang, Yong ^a   Hiroshima, Yukihiko ^a,b,c   Ma, Huaiyu ^a   Zhang, Nan ^a   Zhao, Ming ^a   Hoffman, Robert M ^a,b  

^a ANTICANCER INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

GFP; Human tumors; Imaging; Metastasis; Noninvasive; Nude mice; RFP; Spectral separation; Subcellular in vivo imaging; Tunable filter; Variable magnification

Indexed keywords

ANIMAL; DISEASE MODEL; FEMALE; FLUORESCENCE IMAGING; MOUSE; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; PATHOLOGY; PROCEDURES; SINGLE CELL ANALYSIS;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; OPTICAL IMAGING; SINGLE-CELL ANALYSIS;

EID: 84923645508     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Yang M, Luiken G, Baranov E and Hoffman RM: Facile wholebody imaging of internal fluorescent tumors in mice with an LED flashlight. Biotechniques 39: 170-172, 2005.
2. Yang M, Baranov E, Jiang P, Sun F-X, Li X-M, Li L, Hasegawa S, Bouvet M, Al-Tuwaijri M, Chishima T, Shimada H, Moossa AR, Penman S and Hoffman RM: Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc Natl Acad Sci USA 97: 1206-1211, 2000.
3. Hiroshima Y, Maawy A, Sato S, Murakami T, Uehara F, Miwa S, Yano S, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I and Hoffman RM: Hand-held high resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell line pancreatic tumors growing orthotopically in nude mice. J Surg Res 187: 510-517, 2014.
4. Yamauchi K, Yang M, Jiang P, Xu M, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M and Hoffman RM: Development of real-time subcellular dynamic multicolor imaging of cancer cell-trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res 66: 4208-4214, 2006.
5. Levenson R, Yang M and Hoffman RM: Whole-body dual-color differential fluorescence imaging of tumor angiogenesis enhanced by spectral unmixing. Proc Am Assoc Cancer Res 45: 46, 2004.
6. Mansfield JR, Gossage KW, Hoyt CC and Levenson RM: Autofluorescence removal, multiplexing, and automated analysis methods for in vivo fluorescence imaging. J Biomed Opt 10: 41207, 2005.
7. Hoffman RM and Yang M: Subcellular imaging in the live mouse. Nature Protocols 1: 775-782, 2006.
8. Rashidi B, Moossa AR and Hoffman RM: Specific route mapping visualized with GFP of single-file streaming contralateral and systemic metastasis of Lewis lung carcinoma cells beginning within hours of orthotopic implantation. J Cell Biochem 114: 1738-1743, 2013.
9. Katz MH, Takimoto S, Spivack D, Moossa AR, Hoffman RM and Bouvet M: A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J Surg Res 113: 151-160, 2003.
10. Tran Cao HS, Bouvet M, Kaushal S, Keleman A, Romney E, Kim G, Fruehauf J, Imagawa DK, Hoffman RM and Katz MH: Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer. Mol Cancer Ther 9: 2068-2078, 2010.
11. Gucev ZS, Oh Y, Kelley KM, Labarta JI, Vorwerk P and Rosenfeld RG: Evidence for insulin-like growth factor (IGF)-independent transcriptional regulation of IGF binding protein-3 by growth hormone in SKHEP-1 human hepatocarcinoma cells. Endocrinology 138: 1464-1470, 1997.
12. Rajput A, Dominguez San Martin I, Rose R, Beko A, Levea C, Sharratt E, Mazurchuk R, Hoffman RM, Brattain MG and Wang J: Characterization of HCT116 human colon cancer cells in an orthotopic model. J Surg Res 147: 276-281, 2008.
13. Ke C-C, Liu R-S, Suetsugu A, Kimura H, Ho JH, Lee OK and Hoffman RM: In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells. PLoS One 8: e69658, 2013.
14. Hoffman RM and Yang M: Color-coded fluorescence imaging of tumor-host interactions. Nature Protocols 1: 928-935, 2006.
15. Hoffman RM and Yang M: Whole-body imaging with fluorescent proteins. Nature Protocols 1: 1429-1438, 2006.
16. Hoffman RM: Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Investigational New Drugs 17: 343-359, 1999.
17. Levenson RM and Mansfield JR: Multispectral in biology and medicine: Slices of life. Cytometry 69A: 748-758, 2006.
18. Zhang Y, Miwa S, Zhang N, Hoffman RM, Zhao M. Tumor-targeting Salmonella typhimurium A1-R arrests growth of breastcancer brain metastasis. Oncotarget, in press.
19. Kocher B, Piwnica-Worms D. Illuminating cancer systems with genetically engineered mouse models and coupled luciferase reporters in vivo. Cancer Disc 3: 616-629, 2013.