Acute heart failure in the elderly: Differences in clinical characteristics, outcomes, and prognostic factors in the Veritas study

Journal of Cardiac Failure

Volumn 21, Issue 3, 2015, Pages 179-188

  Metra, Marco ^a   Cotter, Gad ^b   El Khorazaty, Jill ^b   Davison, Beth A ^b   Milo, Olga ^b   Carubelli, Valentina ^a   Bourge, Robert C ^c   Cleland, John G ^d,e   Jondeau, Guillaume ^f   Krum, Henry ^g   O'Connor, Christopher M ^h   Parker, John D ⁱ   Torre Amione, Guillermo ^j,p   Van Veldhuisen, Dirk J ^k   Rainisio, Maurizio ^l   Kobrin, Isaac ^m   McMurray, John J ⁿ   Teerlink, John R ^o  

^a Radiological Sciences and Public Health ^*  (Italy)

^b Momentum Research Inc   (United States)

^c University of Alabama at Birmingham   (United States)

^d ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF HULL   (United Kingdom)

^f BICHAT HOSPITAL   (France)

^g MONASH UNIVERSITY   (Australia)

^h DUKE CLINICAL RESEARCH INSTITUTE   (United States)

ⁱ MOUNT SINAI HOSPITAL   (Canada)

^j HOUSTON METHODIST HOSPITAL   (United States)

^k UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^l Abanovus LLC   (Italy)

^m ACTELION PHARMACEUTICALS LTD   (Switzerland)

ⁿ UNIVERSITY OF GLASGOW   (United Kingdom)

^o UNIVERSITY OF CALIFORNIA   (United States)

^p SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

more..

Author keywords

age; Heart failure; outcomes

Indexed keywords

ALBUMIN; AMIODARONE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; CALCIUM ANTAGONIST; CREATININE; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOBUTAMINE; DOPAMINE; ENDOTHELIN 1; HEMOGLOBIN; LOOP DIURETIC AGENT; NESIRITIDE; NITRIC ACID DERIVATIVE; NITROPRUSSIDE SODIUM; PLACEBO; SODIUM; SPIRONOLACTONE; TEZOSENTAN; TROPONIN I;

ACUTE HEART FAILURE; AGE; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BREATHING RATE; CARDIOVASCULAR MORTALITY; CLINICAL FEATURE; COMORBIDITY; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; GERIATRIC DISORDER; HEART ATRIUM FIBRILLATION; HEMOGLOBIN BLOOD LEVEL; HOSPITAL READMISSION; HUMAN; HYPERTENSION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PARALLEL DESIGN; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); SODIUM BLOOD LEVEL; SYSTOLIC BLOOD PRESSURE; UREA NITROGEN BLOOD LEVEL; ACUTE DISEASE; ATRIAL FIBRILLATION; COMPARATIVE STUDY; CONTROLLED STUDY; HEART FAILURE; HOSPITALIZATION; MIDDLE AGED; MORTALITY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; TRENDS; VERY ELDERLY;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; ATRIAL FIBRILLATION; DOUBLE-BLIND METHOD; FEMALE; HEART FAILURE; HOSPITALIZATION; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; MORTALITY; PROGNOSIS; TREATMENT OUTCOME;

EID: 84923640227     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2014.12.012     Document Type: Article

References (41)

1. A.S. Go, D. Mozaffarian, V.L. Roger, E.J. Benjamin, J.D. Berry, W.B. Borden American Heart Association Statistics Committee, Stroke Statistics Subcommittee Heart disease and stroke statistics-2013 update: a report from the American Heart Association Circulation 127 2013 e6 e245
2. J.J. McMurray, S. Adamopoulos, S.D. Anker, A. Auricchio, M. Bohm, K. Dickstein Task Force for the D, Treatment of A, Chronic Heart Failure of the European Society of C, Guidelines ESCCfP ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) Eur J Heart Fail 14 2012 803 869
3. A. Maisel, C. Mueller, K. Adams Jr., S.D. Anker, N. Aspromonte, and J.G. Cleland State of the art: using natriuretic peptide levels in clinical practice Eur J Heart Fail 10 2008 824 839
4. M. Pfisterer, P. Buser, H. Rickli, M. Gutmann, P. Erne, P. Rickenbacher Time-CHF Investigators BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial J Am Med Assoc 301 2009 383 392
5. J.G. Lainchbury, R.W. Troughton, K.M. Strangman, C.M. Frampton, A. Pilbrow, and T.G. Yandle N-Terminal pro-B-type natriuretic peptide-guided treatment for chronic heart failure: results from the BATTLESCARRED (NT-proBNP-Assisted Treatment to Lessen Serial Cardiac Readmissions and Death) trial J Am Coll Cardiol 55 2009 53 60
6. L.B. Daniels, P. Clopton, M. Potocki, C. Mueller, J. McCord, and M. Richards Influence of age, race, sex, and body mass index on interpretation of midregional pro atrial natriuretic peptide for the diagnosis of acute heart failure: results from the BACH multinational study Eur J Heart Fail 14 2012 22 31
7. J.R. Teerlink, J.J. McMurray, R.C. Bourge, J.G. Cleland, G. Cotter, and G. Jondeau Tezosentan in patients with acute heart failure: design of the Value of Endothelin Receptor Inhibition With Tezosentan in Acute Heart Failure Study (VERITAS) Am Heart J 150 2005 46 53
8. J.J. McMurray, J.R. Teerlink, G. Cotter, R.C. Bourge, J.G. Cleland, and G. Jondeau Effects of tezosentan on symptoms and clinical outcomes in patients with acute heart failure: the VERITAS randomized controlled trials J Am Med Assoc 298 2007 2009 2019
9. G. Cotter, M. Metra, B.A. Davison, S. Senger, R.C. Bourge, J.G. Cleland VERITAS Investigators Worsening heart failure, a critical event during hospital admission for acute heart failure: results from the VERITAS study Eur J Heart Fail 17 2015 109 118
10. O. Milo-Cotter, B. Cotter-Davison, C. Lombardi, H. Sun, L. Bettari, and S. Bugatti Neurohormonal activation in acute heart failure: Results from veritas Cardiology 119 2011 96 105
11. G.Y. Stein, A. Kremer, T. Shochat, T. Bental, R. Korenfeld, and E. Abramson The diversity of heart failure in a hospitalized population: the role of age J Card Fail 18 2012 645 653
12. V. Lazzarini, R.J. Mentz, M. Fiuzat, M. Metra, and C.M. O'Connor Heart failure in elderly patients: distinctive features and unresolved issues Eur J Heart Fail 15 2013 717 723
13. U.M. Mogensen, M. Ersboll, M. Andersen, C. Andersson, C. Hassager, and C. Torp-Pedersen Clinical characteristics and major comorbidities in heart failure patients more than 85 years of age compared with younger age groups Eur J Heart Fail 13 2011 1216 1223
14. K. Dharmarajan, A.F. Hsieh, Z. Lin, H. Bueno, J.S. Ross, and L.I. Horwitz Diagnoses and timing of 30-day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia J Am Med Assoc 309 2013 355 363
15. H.M. Krumholz Post-hospital syndrome-an acquired, transient condition of generalized risk N Engl J Med 368 2013 100 102
16. M. Gheorghiade, M. Vaduganathan, G.C. Fonarow, and R.O. Bonow Rehospitalization for heart failure: problems and perspectives J Am Coll Cardiol 61 2013 391 403
17. H.M. Krumholz, Z. Lin, P.S. Keenan, J. Chen, J.S. Ross, and E.E. Drye Relationship between hospital readmission and mortality rates for patients hospitalized with acute myocardial infarction, heart failure, or pneumonia J Am Med Assoc 309 2013 587 593
18. P.A. Heidenreich, A. Sahay, J.R. Kapoor, M.X. Pham, and B. Massie Divergent trends in survival and readmission following a hospitalization for heart failure in the Veterans Affairs health care system 2002 to 2006 J Am Coll Cardiol 56 2010 362 368
19. R.D. Kociol, L. Liang, A.F. Hernandez, L.H. Curtis, P.A. Heidenreich, and C.W. Yancy Are we targeting the right metric for heart failure? Comparison of hospital 30-day readmission rates and total episode of care inpatient days Am Heart J 165 2013 987 994.e981
20. J.R. Teerlink, G. Cotter, B.A. Davison, G.M. Felker, G. Filippatos, B.H. Greenberg RELAX-AHF Investigators Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial Lancet 381 2013 29 39
21. B.D. Weatherley, O. Milo-Cotter, G.M. Felker, N. Uriel, E. Kaluski, and Z. Vered Early worsening heart failure in patients admitted with acute heart failure-a new outcome measure associated with long-term prognosis? Fundam Clin Pharmacol 23 2009 633 639
22. G. Torre-Amione, O. Milo-Cotter, E. Kaluski, L. Perchenet, I. Kobrin, and A. Frey Early worsening heart failure in patients admitted for acute heart failure: Time course, hemodynamic predictors, and outcome J Card Fail 15 2009 639 644
23. G. Cotter, M. Metra, B.D. Weatherley, H.C. Dittrich, B.M. Massie, and P. Ponikowski Physician-determined worsening heart failure: a novel definition for early worsening heart failure in patients hospitalized for acute heart failure-association with signs and symptoms, hospitalization duration, and 60-day outcomes Cardiology 115 2010 29 36
24. M. Metra, J.R. Teerlink, G.M. Felker, B.H. Greenberg, G. Filippatos, P. Ponikowski, and et al Dyspnoea and worsening heart failure in patients with acute heart failure: results from the PRE-RELAX-AHF study Eur J Heart Fail 12 2010 1130 1139
25. C.M. O'Connor, R.J. Mentz, G. Cotter, M. Metra, J.G. Cleland, and B.A. Davison The protect in-hospital risk model: 7-day outcome in patients hospitalized with acute heart failure and renal dysfunction Eur J Heart Fail 14 2012 605 612
26. M. Metra, G. Cotter, B.A. Davison, G.M. Felker, G. Filippatos, B.H. Greenberg RELAX AHF Investigators Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: Correlation with outcomes J Am Coll Cardiol 61 2013 196 206
27. L.H. Lund, E. Donal, E. Oger, C. Hage, H. Persson, I. Haugen-Lofman KaRen Investigators Association between cardiovascular vs non-cardiovascular co-morbidities and outcomes in heart failure with preserved ejection fraction Eur J Heart Fail 16 2014 992 1001
28. R.W. Schrier Blood urea nitrogen and serum creatinine: Not married in heart failure Circ Heart Fail 1 2008 2 5
29. M. Metra, G. Cotter, M. Gheorghiade, L. Dei Cas, and A.A. Voors The role of the kidney in heart failure Eur Heart J 33 2012 2135 2142
30. M.A. Brisco, S.G. Coca, J. Chen, A.T. Owens, B.D. McCauley, S.E. Kimmel, and J.M. Testani Blood urea nitrogen/creatinine ratio identifies a high-risk but potentially reversible form of renal dysfunction in patients with decompensated heart failure Circ Heart Fail 6 2013 233 239
31. P. van der Meer, D. Postmus, P. Ponikowski, J.G. Cleland, C.M. O'Connor, and G. Cotter The predictive value of short-term changes in hemoglobin concentration in patients presenting with acute decompensated heart failure J Am Coll Cardiol 61 2013 1973 1981
32. S. Uthamalingam, J. Kandala, M. Daley, E. Patvardhan, R. Capodilupo, and S.A. Moore Serum albumin and mortality in acutely decompensated heart failure Am Heart J 160 2010 1149 1155
33. J.L. Januzzi Jr., G. Filippatos, M. Nieminen, and M. Gheorghiade Troponin elevation in patients with heart failure: On behalf of the third universal definition of myocardial infarction global task force: Heart failure section Eur Heart J 33 2012 2265 2271
34. R.D. Kociol, P.S. Pang, M. Gheorghiade, G.C. Fonarow, C.M. O'Connor, and G.M. Felker Troponin elevation in heart failure prevalence, mechanisms, and clinical implications J Am Coll Cardiol 56 2010 1071 1078
35. J.J. McMurray, S.G. Ray, I. Abdullah, H.J. Dargie, and J.J. Morton Plasma endothelin in chronic heart failure Circulation 85 1992 1374 1379
36. S. Masson, R. Latini, I.S. Anand, S. Barlera, D. Judd, M. Salio Val-HeFT Investigators The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT) J Card Fail 12 2006 375 380
37. C. Adlbrecht, M. Hulsmann, G. Strunk, R. Berger, D. Mortl, and J. Struck Prognostic value of plasma midregional pro-adrenomedullin and c-terminal-pro-endothelin-1 in chronic heart failure outpatients Eur J Heart Fail 11 2009 361 366
38. E.A. Jankowska, G.S. Filippatos, S. von Haehling, J. Papassotiriou, N.G. Morgenthaler, and M. Cicoira Identification of chronic heart failure patients with a high 12-month mortality risk using biomarkers including plasma c-terminal pro-endothelin-1 PloS One 6 2011 e14506
39. A. Harrison, L.K. Morrison, P. Krishnaswamy, R. Kazanegra, P. Clopton, and Q. Dao B-Type natriuretic peptide predicts future cardiac events in patients presenting to the emergency department with dyspnea Ann Emerg Med 39 2002 131 138
40. D. Logeart, G. Thabut, P. Jourdain, C. Chavelas, P. Beyne, and F. Beauvais Predischarge B-type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure J Am Coll Cardiol 43 2004 635 641
41. M. Metra, S. Nodari, G. Parrinello, C. Specchia, L. Brentana, and P. Rocca The role of plasma biomarkers in acute heart failure. Serial changes and independent prognostic value of NT-proBNP and cardiac troponin-T Eur J Heart Fail 9 2007 776 786