Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension

Journal of the American Chemical Society

Volumn 137, Issue 7, 2015, Pages 2769-2775

  Heuberger, Benjamin D ^a,b   Pal, Ayan ^a   Del Frate, Francesca ^a   Topkar, Ved V ^a   Szostak, Jack W ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Human Centered Solutions   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOMERS; OLIGONUCLEOTIDES; THERMODYNAMIC STABILITY;

ACTIVATED MONOMERS; NON-ENZYMATIC; NON-ENZYMATIC REPLICATION; ORIGIN OF LIFE; PRIMER EXTENSION; RNA REPLICATION; SEQUENCE TEMPLATES; SINGLE ATOMS;

RNA;

2 THIOURIDINE; MONOMER; PRIMER RNA; THIOURIDINE; UNCLASSIFIED DRUG; URIDINE; 2-THIOURIDINE; RNA; RNA PRIMERS;

ARTICLE; ATOM; KINETICS; SUBSTITUTION REACTION; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION;

KINETICS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; RNA; THIOURIDINE;

EID: 84923612842     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b00445     Document Type: Article

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