MicroRNA 26a modulates regulatory T cells expansion and attenuates renal ischemia-reperfusion injury

Molecular Immunology

Volumn 65, Issue 2, 2015, Pages 321=327-327

  Liang, Simin ^a   Wang, Wenxuan ^a   Gou, Xin ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

IL 6; Mir 26a; Regulatory T cells; Renal IRI

Indexed keywords

INTERLEUKIN 6; LENTIVIRUS VECTOR; MICRORNA 26A; TRANSCRIPTION FACTOR FOXP3; ANTIBODY; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; IL2RA PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR ALPHA; MICRORNA; MIRN26 MICRORNA, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; GENE OVEREXPRESSION; GENE REPRESSION; IMMUNOMODULATION; KIDNEY; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY TUBULE DAMAGE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; RENAL PROTECTION; REPERFUSION INJURY; SPLEEN; T LYMPHOCYTE ACTIVATION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; ACUTE KIDNEY INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; GENETICS; IMMUNOLOGY; LYMPHOCYTE DEPLETION; METABOLISM; PATHOLOGY;

ACUTE KIDNEY INJURY; ANIMALS; ANTIBODIES; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-6; KIDNEY; LYMPHOCYTE DEPLETION; MICE; MICRORNAS; REPERFUSION INJURY; SPLEEN; T-LYMPHOCYTES, REGULATORY; UP-REGULATION;

EID: 84923574405     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2015.02.003     Document Type: Article

References (43)

1. Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
2. Borsellino G., Kleinewietfeld M., Di Mitri D., Sternjak A., Diamantini A., Giometto R., Hopner S., Centonze D., Bernardi G., Dell'Acqua M.L., Rossini P.M., Battistini L., Rotzschke O., Falk K. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 2007, 110:1225-1232.
3. Burne-Taney M.J., Ascon D.B., Daniels F., Racusen L., Baldwin W., Rabb H. B cell deficiency confers protection from renal ischemia reperfusion injury. J. Immunol. 2003, 171:3210-3215.
4. Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., Wahl S.M. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003, 198:1875-1886.
5. Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., Wahl S.M. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003, 198:1875-1886.
6. Chen L., Zheng J., Zhang Y., Yang L., Wang J., Ni J., Cui D., Yu C., Cai Z. Tumor-specific expression of microRNA-26a suppresses human hepatocellular carcinoma growth via cyclin-dependent and -independent pathways. Mol. Ther. 2011, 19:1521-1528.
7. Cohen J.L., Trenado A., Vasey D., Klatzmann D., Salomon B.L. CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 2002, 196:401-406.
8. Day Y.J., Huang L., Ye H., Li L., Linden J., Okusa M.D. Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gamma. J. Immunol. 2006, 176:3108-3114.
9. Eltzschig H.K., Eckle T. Ischemia and reperfusion-from mechanism to translation. Nat. Med. 2011, 17:1391-1401.
10. Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003, 4:330-336.
11. Gandolfo M.T., Jang H.R., Bagnasco S.M., Ko G.J., Agreda P., Satpute S.R., Crow M.T., King L.S., Rabb H. Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury. Kidney Int. 2009, 76:717-729.
12. Jo S.K., Sung S.A., Cho W.Y., Go K.J., Kim H.K. Macrophages contribute to the initiation of ischaemic acute renal failure in rats. Nephrol. Dial. Transplant. 2006, 21:1231-1239.
13. Kim K.D., Zhao J., Auh S., Yang X., Du P., Tang H., Fu Y.X. Adaptive immune cells temper initial innate responses. Nat. Med. 2007, 13:1248-1252.
14. Kim M.G., Boo C.S., Ko Y.S., Lee H.Y., Cho W.Y., Kim H.K., Jo S.K. Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury. Nephrol. Dial. Transplant. 2010, 25:2908-2921.
15. Kim M.G., Koo T.Y., Yan J.J., Lee E., Han K.H., Jeong J.C., Ro H., Kim B.S., Jo S.K., Oh K.H., Surh C.D., Ahn C., Yang J. IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells. J. Am. Soc. Nephrol. 2013, 24:1529-1536.
16. Kinsey G.R., Sharma R., Huang L., Li L., Vergis A.L., Ye H., Ju S.T., Okusa M.D. Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury. J. Am. Soc. Nephrol. 2009, 20:1744-1753.
17. Ko G.J., Boo C.S., Jo S.K., Cho W.Y., Kim H.K. Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury. Nephrol. Dial. Transplant. 2008, 23:842-852.
18. Kobie J.J., Shah P.R., Yang L., Rebhahn J.A., Fowell D.J., Mosmann T.R. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J. Immunol. 2006, 177:6780-6786.
19. Kono H., Rock K.L. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 2008, 8:279-289.
20. Lee V.W., Wang Y.M., Wang Y.P., Zheng D., Polhill T., Cao Q., Wu H., Alexander I.E., Alexander S.I., Harris D.C. Regulatory immune cells in kidney disease. Am. J. Physiol. Renal Physiol. 2008, 295:F335-F342.
21. Leeper N.J., Raiesdana A., Kojima Y., Chun H.J., Azuma J., Maegdefessel L., Kundu R.K., Quertermous T., Tsao P.S., Spin J.M. MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. J. Cell. Physiol. 2011, 226:1035-1043.
22. Lewkowicz P., Lewkowicz N., Sasiak A., Tchorzewski H. Lipopolysaccharide-activated CD4+CD25+ T regulatory cells inhibit neutrophil function and promote their apoptosis and death. J. Immunol. 2006, 177:7155-7163.
23. Li M.O., Sanjabi S., Flavell R.A. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 2006, 25:455-471.
24. Li L., Huang L., Sung S.S., Lobo P.I., Brown M.G., Gregg R.K., Engelhard V.H., Okusa M.D. NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. J. Immunol. 2007, 178:5899-5911.
25. Liu B., Wu X., Liu B., Wang C., Liu Y., Zhou Q., Xu K. MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN. Biochim. Biophys. Acta 2012, 1822:1692-1704.
26. Lu J., Getz G., Miska E.A., Alvarez-Saavedra E., Lamb J., Peck D., Sweet-Cordero A., Ebert B.L., Mak R.H., Ferrando A.A., Downing J.R., Jacks T., Horvitz H.R., Golub T.R. MicroRNA expression profiles classify human cancers. Nature 2005, 435:834-838.
27. Mahajan D., Wang Y., Qin X., Wang Y., Zheng G., Wang Y.M., Alexander S.I., Harris D.C. CD4+CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease. J. Am. Soc. Nephrol. 2006, 17:2731-2741.
28. Mira E., Leon B., Barber D.F., Jimenez-Baranda S., Goya I., Almonacid L., Marquez G., Zaballos A., Martinez-A C., Stein J.V., Ardavin C., Manes S. Statins induce regulatory T cell recruitment via a CCL1 dependent pathway. J. Immunol. 2008, 181:3524-3534.
29. Morgan M.E., Flierman R., van Duivenvoorde L.M., Witteveen H.J., van Ewijk W., van Laar J.M., de Vries R.R., Toes R.E. Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis Rheum. 2005, 52:2212-2221.
30. Mottet C., Uhlig H.H., Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J. Immunol. 2003, 170:3939-3943.
31. Murphy T.J., Ni C.N., Zang Y., Mannick J.A., Lederer J.A. CD4+CD25+ regulatory T cells control innate immune reactivity after injury. J. Immunol. 2005, 174:2957-2963.
32. Ni B., Rajaram M.V., Lafuse W.P., Landes M.B., Schlesinger L.S. Mycobacterium tuberculosis decreases human macrophage IFN-gamma responsiveness through miR-132 and miR-26a. J. Immunol. 2014, 193:4537-4547.
33. O'Connell R.M., Rao D.S., Chaudhuri A.A., Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat. Rev. Immunol. 2010, 10:111-122.
34. Roncarolo M.G., Battaglia M. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat. Rev. Immunol. 2007, 7:585-598.
35. Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004, 22:531-562.
36. Scalapino K.J., Tang Q., Bluestone J.A., Bonyhadi M.L., Daikh D.I. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J. Immunol. 2006, 177:1451-1459.
37. Star R.A. Treatment of acute renal failure. Kidney Int. 1998, 54:1817-1831.
38. Tiscornia G., Singer O., Verma I.M. Production and purification of lentiviral vectors. Nat. Protoc. 2006, 1:241-245.
39. Xu H., Yao Y., Smith L.P., Nair V. MicroRNA-26a-mediated regulation of interleukin-2 expression in transformed avian lymphocyte lines. Cancer Cell Int. 2010, 10:15.
40. Zhang B., Liu X.X., He J.R., Zhou C.X., Guo M., He M., Li M.F., Chen G.Q., Zhao Q. Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis 2011, 32:2-9.
41. Zhang R., Tian A., Wang J., Shen X., Qi G., Tang Y. miR26a modulates T17/T balance in the EAE model of multiple sclerosis by targeting IL6. Neuromolecular Med. 2015, 17:24-34.
42. Zhou L., Lopes J.E., Chong M.M., Ivanov I.I., Min R., Victora G.D., Shen Y., Du J., Rubtsov Y.P., Rudensky A.Y., Ziegler S.F., Littman D.R. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008, 453:236-240.
43. Zhu X.Y., Ebrahimi B., Eirin A., Woollard J.R., Tang H., Jordan K.L., Ofori M., Saad A., Herrmann S.M., Dietz A.B., Textor S.C., Lerman A., Lerman L.O. Renal vein levels of MicroRNA-26a are lower in the poststenotic kidney. J. Am. Soc. Nephrol. 2014.