N-methyl pyrrolidone/bone morphogenetic protein-2 double delivery with in situ forming implants

Journal of Controlled Release

Volumn 203, Issue , 2015, Pages 181-188

  Karfeld Sulzer, Lindsay S ^a   Ghayor, Chafik ^a   Siegenthaler, Barbara ^a,b   De Wild, Michael ^c   Leroux, Jean Christophe ^d   Weber, Franz E ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^d ETH ZURICH   (Switzerland)

Author keywords

Bone morphogenetic proteins; Bone regeneration; Double delivery; Glycolide; Lactide; N methylpyrrolidone; Poly(lactide co glycolide)

Indexed keywords

BONE; DEFECTS; PLANTS (BOTANY);

BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; DOUBLE DELIVERY; GLYCOLIDE; LACTIDES; N-METHYLPYRROLIDONE; POLY LACTIDE-CO-GLYCOLIDE;

PROTEINS;

1 METHYL 2 PYRROLIDINONE; POLYGLACTIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; 2 PYRROLIDONE DERIVATIVE; BONE MORPHOGENETIC PROTEIN 2; DRUG IMPLANT; N-METHYLPYRROLIDONE; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ARTICLE; BONE REGENERATION; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG IMPLANT; IN VIVO STUDY; MOLECULAR WEIGHT; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RABBIT; SLOW DRUG RELEASE; TREATMENT DURATION; ANIMAL; BONE DEVELOPMENT; CHEMISTRY; DRUG EFFECTS; INJURIES; PHYSIOLOGY; SKULL;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; DRUG IMPLANTS; OSTEOGENESIS; POLYGLACTIN 910; PYRROLIDINONES; RABBITS; RECOMBINANT PROTEINS; SKULL; TRANSFORMING GROWTH FACTOR BETA;

EID: 84923545700     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.02.019     Document Type: Article

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