Effect of genetic deletion or pharmacological antagonism of tumor necrosis factor alpha on colitis-associated carcinogenesis in mice

Inflammatory Bowel Diseases

Volumn 21, Issue 3, 2015, Pages 485-495

  Craven, Brian ^a   Zaric, Violeta ^a   Martin, Abigail ^a   Mureau, Coralie ^a   Egan, Laurence John ^a  

^a UNIVERSITY HOSPITAL GALWAY   (Ireland)

Author keywords

colitis; inflammatory bowel disease; NF B; TNF ; tumor

Indexed keywords

AZOXYMETHANE; CD83 ANTIGEN; CXCL1 CHEMOKINE; DEXTRAN SULFATE; ETANERCEPT; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; RNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; CARCINOGEN; CYTOKINE; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; COLITIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE DELETION; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; STEREOTACTIC PROCEDURE; TUMOR GROWTH; UPREGULATION; WEIGHT REDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL TRANSFORMATION; CHEMICALLY INDUCED; COLONIC NEOPLASMS; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AZOXYMETHANE; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; COLITIS; COLONIC NEOPLASMS; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; ETANERCEPT; FEMALE; MICE; MICE, KNOCKOUT; NF-KAPPA B; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84923519067     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0000000000000303     Document Type: Article

References (30)

1. Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet. 2007; 369: 1641-1657.
2. Loftus EV Jr. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 2004; 126: 1504-1517.
3. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007; 448: 427-434.
4. Grivennikov S, Karin E, Terzic J, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-Associated cancer. Cancer Cell. 2009; 15: 103-113.
5. Greten FR, Eckmann L, Greten TF, et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-Associated cancer. Cell. 2004; 118: 285-296.
6. Popivanova BK, Kitamura K, Wu Y, et al. Blocking TNF-Alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest. 2008; 118: 560-570.
7. Dobbins WO III. Dysplasia and malignancy in inflammatory bowel disease. Annu Rev Med. 1984; 35: 33-48.
8. Bromberg J, Wang TC. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell. 2009; 15: 79-80.
9. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010; 140: 883-899.
10. Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell. 2002; 109(suppl): S81-S96.
11. Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008; 132: 344-362.
12. Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol. 2002; 3: 221-227.
13. Liu ZG. Molecular mechanism of TNF signaling and beyond. Cell Res. 2005; 15: 24-27.
14. Aggarwal BB. Signalling pathways of the TNF superfamily: a doubleedged sword. Nat Rev Immunol. 2003; 3: 745-756.
15. Chinnaiyan AM, O'Rourke K, Tewari M, et al. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995; 81: 505-512.
16. Hsu H, Shu HB, Pan MG, et al. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996; 84: 299-308.
17. Hsu H, Huang J, Shu HB, et al. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity. 1996; 4: 387-396.
18. Stanger BZ, Leder P, Lee TH, et al. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell. 1995; 81: 513-523.
19. Rothe M, Wong SC, Henzel WJ, et al. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994; 78: 681-692.
20. Wang K, Han G, Dou Y, et al. Opposite role of tumor necrosis factor receptors in dextran sulfate sodium-induced colitis in mice. PLoS One. 2012; 7: e52924.
21. Stillie R, Stadnyk AW. Role of TNF receptors, TNFR1 and TNFR2, in dextran sodium sulfate-induced colitis. Inflamm Bowel Dis. 2009; 15: 1515-1525.
22. Peppel K, Crawford D, Beutler B. A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity. J Exp Med. 1991; 174: 1483-1489.
23. MacDonald TT. The role of activated T lymphocytes in gastrointestinal disease. Clin Exp Allergy. 1990; 20: 247-252.
24. Bouma G, Xia B, Crusius JB, et al. Distribution of four polymorphisms in the tumour necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD). Clin Exp Immunol. 1996; 103: 391-396.
25. Lowenthal JW, Ballard DW, Bogerd H, et al. Tumor necrosis factor-Alpha activation of the IL-2 receptor-Alpha gene involves the induction of kappa B-specific DNA binding proteins. J Immunol. 1989; 142: 3121-3128.
26. Rogler G, Brand K, Vogl D, et al. Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology. 1998; 115: 357-369.
27. Sakai H, Yamada Y, Shimizu M, et al. Genetic ablation of Tnfalpha demonstrates no detectable suppressive effect on inflammation-related mouse colon tumorigenesis. Chem Biol Interact. 2010; 184: 423-430.
28. Chang F, Lacey MR, Bouljihad M, et al. Tumor necrosis factor receptor 1 functions as a tumor suppressor. Am J Physiol Gastrointest Liver Physiol. 2012; 302: G195-G206.
29. Shuai K, Liu B. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol. 2003; 3: 900-911.
30. Lin J, Zhang Z, Zeng S, et al. TRAIL-induced apoptosis proceeding from caspase-3-dependent and-independent pathways in distinct HeLa cells. Biochem Biophys Research Commun. 2006; 346: 1136-1141.