Heat stress-induced disruption of endothelial barrier function is via PAR1 signaling and suppressed by Xuebijing injection

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Xu, Qiulin ^a,b   Liu, Jingxian ^c   Wang, Zhenglian ^d   Guo, Xiaohua ^c   Zhou, Gengbiao ^d   Liu, Yanan ^c   Huang, Qiaobing ^c   Su, Lei ^a  

^a GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^b Postdoctoral Workstation Huabo Bio pharmaceutical Research Institute   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

F ACTIN; G PROTEIN COUPLED RECEPTOR; HERBACEOUS AGENT; MOESIN; NEUTRALIZING ANTIBODY; PROTEINASE ACTIVATED RECEPTOR 1; SMALL INTERFERING RNA; THROMBIN; UNCLASSIFIED DRUG; XUEBIJING;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL PERMEABILITY; CHINESE MEDICINE; CONTROLLED STUDY; DRUG MECHANISM; ELECTRIC RESISTANCE; ENZYME INHIBITION; HEAT STRESS; HEAT STROKE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG EDEMA; MALE; MICROVASCULARIZATION; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEPSIS; UMBILICAL VEIN ENDOTHELIAL CELL; ACTIN FILAMENT; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; DRUG EFFECTS; ENDOTHELIUM CELL; HEAT; LUNG LAVAGE; METABOLISM; RESPIRATORY DISTRESS SYNDROME, ADULT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

MUS;

ACTIN CYTOSKELETON; ACUTE LUNG INJURY; ANIMALS; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE; CAPILLARY PERMEABILITY; DRUGS, CHINESE HERBAL; ENDOTHELIAL CELLS; HOT TEMPERATURE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; RECEPTOR, PAR-1; RESPIRATORY DISTRESS SYNDROME, ADULT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84923381976     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118057     Document Type: Article

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