A putative antipruritic mechanism of the phosphodiesterase-4 inhibitor E6005 by attenuating capsaicin-induced depolarization of C-fibre nerves

Experimental Dermatology

Volumn 24, Issue 3, 2015, Pages 215-216

  Wakita, Hisashi ^a   Ohkuro, Masayoshi ^a   Ishii, Naoto ^a   Hishinuma, Ieharu ^a   Shirato, Manabu ^a  

^a EISAI CO LTD   (Japan)

Author keywords

Antipruritic effect; C fibre nerve; cAMP; Phosphodiesterase 4

Indexed keywords

ANTIPRURITIC AGENT; BETAMETHASONE; CAPSAICIN; CYCLIC AMP; E 6005; FORSKOLIN; PHOSPHODIESTERASE IV INHIBITOR; ROFLUMILAST; TACROLIMUS; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; METHYL 4-(((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)AMINO)CARBONYL)BENZOATE; PHTHALIC ACID DERIVATIVE; QUINAZOLINE DERIVATIVE; TRPV1 PROTEIN, RAT; VANILLOID RECEPTOR;

ANIMAL CELL; ANTIPRURITIC ACTIVITY; ARTICLE; CELL LEVEL; DRUG ACTIVITY; DRUG MECHANISM; MALE; MEMBRANE DEPOLARIZATION; NERVE CELL; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE POTENTIAL; NONHUMAN; PROTEIN CONTENT; PRURITUS; RAT; SPINAL GANGLION; ACTION POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; NERVE FIBER; PHYSIOLOGY; WISTAR RAT;

ACTION POTENTIALS; ANIMALS; ANTIPRURITICS; CAPSAICIN; CYCLIC AMP; GANGLIA, SPINAL; MALE; NERVE FIBERS; PHOSPHODIESTERASE 4 INHIBITORS; PHTHALIC ACIDS; QUINAZOLINES; RATS; RATS, WISTAR; TRPV CATION CHANNELS;

EID: 84923373197     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/exd.12606     Document Type: Article

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