Inhibition of CDC25B phosphatase through disruption of protein-protein interaction

ACS Chemical Biology

Volumn 10, Issue 2, 2015, Pages 390-394

  Lund, George ^a   Dudkin, Sergii ^a   Borkin, Dmitry ^a   Ni, Wendi ^a   Grembecka, Jolanta ^a   Cierpicki, Tomasz ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUORO 4 HYDROXYBENZONITRILE DERIVATIVE; ANTINEOPLASTIC AGENT; CYCLIN A; CYCLIN DEPENDENT KINASE 2; ENZYME INHIBITOR; PHOSPHATASE; PROTEIN CDC25B; UNCLASSIFIED DRUG; MOLECULAR LIBRARY; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; CELL CYCLE REGULATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; CRYSTALLIZATION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR LIBRARY; MOLECULAR MODEL; PHYSIOLOGY;

BINDING SITES; CDC25 PHOSPHATASES; CRYSTALLIZATION; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; ENZYME INHIBITORS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEIN BINDING; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84923369622     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500883h     Document Type: Article

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