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Volumn 14, Issue 2, 2015, Pages 542-552

Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; ANTINEOPLASTIC AGENT; AZD 9291; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; PACLITAXEL; UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; ANILINE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; OSIMERTINIB; QUINAZOLINE DERIVATIVE;

EID: 84923352396     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-14-0723     Document Type: Article
Times cited : (27)

References (42)
  • 1
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 2
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 3
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations arecommonin lung cancers from "never smokers"and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, et al. EGF receptor gene mutations arecommonin lung cancers from "never smokers"and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-11.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3    Doherty, J.4    Politi, K.5    Sarkaria, I.6
  • 5
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-8.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5    Tsurutani, J.6
  • 7
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011;12:735-42.
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3    Feng, J.4    Liu, X.Q.5    Wang, C.6
  • 8
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-46.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3    Vergnenegre, A.4    Massuti, B.5    Felip, E.6
  • 9
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin pluspemetrexed inpatientswithmetastatic lung adenocarcinoma with EGFR mutations
    • Sequist LV, Yang JC, Yamamoto N, O'Byrne K, Hirsh V, MokT, et al. Phase III study of afatinib or cisplatin pluspemetrexed inpatientswithmetastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 2013;31:3327-34.
    • (2013) J Clin Oncol , vol.31 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3    O'Byrne, K.4    Hirsh, V.5    Mok, T.6
  • 10
    • 84875950992 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease
    • Ohashi K, Maruvka YE, Michor F, Pao W. Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease. J Clin Oncol 2013;31:1070-80.
    • (2013) J Clin Oncol , vol.31 , pp. 1070-1080
    • Ohashi, K.1    Maruvka, Y.E.2    Michor, F.3    Pao, W.4
  • 11
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73.
    • (2005) PLoS Med , vol.2 , pp. e73
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 13
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3    Song, Y.4    Hyland, C.5    Park, J.O.6
  • 14
    • 84867760241 scopus 로고    scopus 로고
    • HER2 amplification: A potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
    • Takezawa K, Pirazzoli V, Arcila ME, Nebhan CA, Song X, de Stanchina E, et al. HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov 2012;2:922-33.
    • (2012) Cancer Discov , vol.2 , pp. 922-933
    • Takezawa, K.1    Pirazzoli, V.2    Arcila, M.E.3    Nebhan, C.A.4    Song, X.5    De Stanchina, E.6
  • 15
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 2007;104:20932-7.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 17
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
    • Zhang Z, Lee JC, Lin L, Olivas V, Au V, LaFramboise T, et al. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat Genet 2012;44:852-60.
    • (2012) Nat Genet , vol.44 , pp. 852-860
    • Zhang, Z.1    Lee, J.C.2    Lin, L.3    Olivas, V.4    Au, V.5    LaFramboise, T.6
  • 19
    • 33745913034 scopus 로고    scopus 로고
    • Kris MGMemorial Sloan-Kettering Cancer Center Lung Cancer OncoGenome G. EGFR mutations in small-cell lung cancers in patients who have never smoked
    • Zakowski MF, Ladanyi M, Kris MGMemorial Sloan-Kettering Cancer Center Lung Cancer OncoGenome G. EGFR mutations in small-cell lung cancers in patients who have never smoked. N Engl J Med 2006;355:213-5.
    • (2006) N Engl J Med , vol.355 , pp. 213-215
    • Zakowski, M.F.1    Ladanyi, M.2
  • 20
    • 70349684791 scopus 로고    scopus 로고
    • Dual targeting of EGFR can overcomea major drug resistance mutation in mouse models of EGFR mutant lung cancer
    • Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, et al. Dual targeting of EGFR can overcomea major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest 2009;119:3000-10.
    • (2009) J Clin Invest , vol.119 , pp. 3000-3010
    • Regales, L.1    Gong, Y.2    Shen, R.3    De Stanchina, E.4    Vivanco, I.5    Goel, A.6
  • 21
    • 84906911022 scopus 로고    scopus 로고
    • Dual inhibition of EGFR with afatinib and cetuximab in kinase inhibitor-resistant EGFR-mutant lung cancer with and without T790M mutations
    • Janjigian YY, Smit EF, Groen HJ, Horn L, Gettinger S, Camidge DR, et al. Dual inhibition of EGFR with afatinib and cetuximab in kinase inhibitor-resistant EGFR-mutant lung cancer with and without T790M mutations. Cancer Discov 2014;4:1036-45.
    • (2014) Cancer Discov , vol.4 , pp. 1036-1045
    • Janjigian, Y.Y.1    Smit, E.F.2    Groen, H.J.3    Horn, L.4    Gettinger, S.5    Camidge, D.R.6
  • 22
    • 84901275269 scopus 로고    scopus 로고
    • Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1
    • Pirazzoli V, Nebhan C, Song X, Wurtz A, Walther Z, Cai G, et al. Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1. Cell Rep 2014;7:999-1008.
    • (2014) Cell Rep , vol.7 , pp. 999-1008
    • Pirazzoli, V.1    Nebhan, C.2    Song, X.3    Wurtz, A.4    Walther, Z.5    Cai, G.6
  • 23
    • 84904624695 scopus 로고    scopus 로고
    • Clinical activity of the mutant-selective EGFR inhibitor AZD9291 in patients (pts) with EGFR inhibitor-resistant non-small cell lung cancer (NSCLC)
    • Janne PA, Ramalingam SS, Chih-Hsin Yang J, Ahn M-J, Kim D-W, Kim S-W, et al. Clinical activity of the mutant-selective EGFR inhibitor AZD9291 in patients (pts) with EGFR inhibitor-resistant non-small cell lung cancer (NSCLC). J Clin Oncol 32:5s, 2014 (suppl; abstr 8009 ?).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Janne, P.A.1    Ramalingam, S.S.2    Chih-Hsin Yang, J.3    Ahn, M.-J.4    Kim, D.-W.5    Kim, S.-W.6
  • 24
    • 84904657511 scopus 로고    scopus 로고
    • First-in-human evaluation of CO-1686, an irreversible, highly selective tyrosine kinase inhibitor of mutations in EGFR (activating and T790M)
    • Sequist LV, Soria J-C, Gadgeel SM, Wakelee HA, Camidge DR, Varga A, et al. First-in-human evaluation of CO-1686, an irreversible, highly selective tyrosine kinase inhibitor of mutations in EGFR (activating and T790M). J Clin Oncol 32:5s, 2014 (suppl; abstr 8010 ?).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Sequist, L.V.1    Soria, J.-C.2    Gadgeel, S.M.3    Wakelee, H.A.4    Camidge, D.R.5    Varga, A.6
  • 25
    • 84906936412 scopus 로고    scopus 로고
    • Clinical activity and safety of HM61713, an EGFR-mutant selective inhibitor, in advanced non-small cell lung cancer (NSCLC) in patients (pts)with EGFR mutations who had received EGFR tyrosine kinase inhibitors (TKIs)
    • Kim D-W, Lee DH, Kang JH, Park K, Han J-Y, Lee J-S, et al. Clinical activity and safety of HM61713, an EGFR-mutant selective inhibitor, in advanced non-small cell lung cancer (NSCLC) in patients (pts)with EGFR mutations who had received EGFR tyrosine kinase inhibitors (TKIs). J Clin Oncol 32:5s, 2014 (suppl; abstr 8011).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Kim, D.-W.1    Lee, D.H.2    Kang, J.H.3    Park, K.4    Han, J.-Y.5    Lee, J.-S.6
  • 26
    • 84904898065 scopus 로고    scopus 로고
    • AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
    • Cross DA, Ashton SE, Ghiorghiu S, Eberlein C, Nebhan CA, Spitzler PJ, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov 2014;4:1046-61.
    • (2014) Cancer Discov , vol.4 , pp. 1046-1061
    • Cross, D.A.1    Ashton, S.E.2    Ghiorghiu, S.3    Eberlein, C.4    Nebhan, C.A.5    Spitzler, P.J.6
  • 27
    • 79960085862 scopus 로고    scopus 로고
    • Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling
    • Chmielecki J, Foo J, Oxnard GR, Hutchinson K, Ohashi K, Somwar R, et al. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Sci Transl Med 2011;3:90ra59.
    • (2011) Sci Transl Med , vol.3 , pp. 90ra59
    • Chmielecki, J.1    Foo, J.2    Oxnard, G.R.3    Hutchinson, K.4    Ohashi, K.5    Somwar, R.6
  • 28
    • 84864524696 scopus 로고    scopus 로고
    • Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
    • Ohashi K, Sequist LV, Arcila ME, Moran T, Chmielecki J, Lin YL, et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc Natl Acad Sci U S A 2012;109:E2127-33.
    • Proc Natl Acad Sci U S A 2012 , vol.109 , pp. E2127-E2133
    • Ohashi, K.1    Sequist, L.V.2    Arcila, M.E.3    Moran, T.4    Chmielecki, J.5    Lin, Y.L.6
  • 29
    • 77949587649 scopus 로고    scopus 로고
    • Fast and accurate long-read alignment with Burrows-Wheeler transform
    • Li H, Durbin R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 2010;26:589-95.
    • (2010) Bioinformatics , vol.26 , pp. 589-595
    • Li, H.1    Durbin, R.2
  • 30
    • 77956295988 scopus 로고    scopus 로고
    • The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
    • McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 2010;20:1297-303.
    • (2010) Genome Res , vol.20 , pp. 1297-1303
    • McKenna, A.1    Hanna, M.2    Banks, E.3    Sivachenko, A.4    Cibulskis, K.5    Kernytsky, A.6
  • 34
    • 77956534324 scopus 로고    scopus 로고
    • ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
    • Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 2010;38:e164.
    • (2010) Nucleic Acids Res , vol.38 , pp. e164
    • Wang, K.1    Li, M.2    Hakonarson, H.3
  • 35
    • 35648965243 scopus 로고    scopus 로고
    • Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
    • Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, et al. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med 2007;4:e294.
    • (2007) PLoS Med , vol.4 , pp. e294
    • Gong, Y.1    Somwar, R.2    Politi, K.3    Balak, M.4    Chmielecki, J.5    Jiang, X.6
  • 36
    • 42249086436 scopus 로고    scopus 로고
    • The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor
    • Godin-Heymann N, Ulkus L, Brannigan BW, McDermott U, Lamb J, Maheswaran S, et al. The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor. Mol Cancer Ther 2008;7:874-9.
    • (2008) Mol Cancer Ther , vol.7 , pp. 874-879
    • Godin-Heymann, N.1    Ulkus, L.2    Brannigan, B.W.3    McDermott, U.4    Lamb, J.5    Maheswaran, S.6
  • 37
    • 34548009812 scopus 로고    scopus 로고
    • Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line
    • Ogino A, Kitao H, Hirano S, Uchida A, Ishiai M, Kozuki T, et al. Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line. Cancer Res 2007;67:7807-14.
    • (2007) Cancer Res , vol.67 , pp. 7807-7814
    • Ogino, A.1    Kitao, H.2    Hirano, S.3    Uchida, A.4    Ishiai, M.5    Kozuki, T.6
  • 40
    • 84878957482 scopus 로고    scopus 로고
    • Sequential inhibitor therapy in CML: In vitro simulation elucidates the pattern of resistance mutations after second- and third-line treatment
    • Bauer RC, Sanger J, Peschel C, Duyster J, von Bubnoff N. Sequential inhibitor therapy in CML: in vitro simulation elucidates the pattern of resistance mutations after second- and third-line treatment. Clin Cancer Res 2013;19:2962-72.
    • (2013) Clin Cancer Res , vol.19 , pp. 2962-2972
    • Bauer, R.C.1    Sanger, J.2    Peschel, C.3    Duyster, J.4    Von Bubnoff, N.5
  • 41
    • 33644675811 scopus 로고    scopus 로고
    • Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgen-receptor signaling axis
    • Scher HI, Sawyers CL. Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol 2005;23:8253-61.
    • (2005) J Clin Oncol , vol.23 , pp. 8253-8261
    • Scher, H.I.1    Sawyers, C.L.2
  • 42
    • 84890078624 scopus 로고    scopus 로고
    • Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade
    • Arora VK, Schenkein E, Murali R, Subudhi SK, Wongvipat J, Balbas MD, et al. Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade. Cell 2013;155:1309-22.
    • (2013) Cell , vol.155 , pp. 1309-1322
    • Arora, V.K.1    Schenkein, E.2    Murali, R.3    Subudhi, S.K.4    Wongvipat, J.5    Balbas, M.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.