Effects of genetic polymorphisms on antioxidant status and concentrations of the metals in the blood of riverside Amazonian communities co-exposed to Hg and Pb

Environmental Research

Volumn 138, Issue , 2015, Pages 224-232

  Barcelos, Gustavo Rafael Mazzaron ^a   Souza, Marilesia Ferreira de ^b   Oliveira, Andréia Ávila Soares de ^a   Lengert, André van Helvoort ^b   Oliveira, Marcelo Tempesta de ^b   Camargo, Rossana Batista de Oliveira Godoy ^b   Grotto, Denise ^a   Valentini, Juliana ^a   Garcia, Solange Cristina ^c   Braga, Gilberto Úbida Leite ^a   Cólus, Ilce Mara de Syllos ^b   Adeyemi, Joseph ^d   Barbosa, Fernando ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d OSUN STATE UNIVERSITY   (Nigeria)

Author keywords

Antioxidant parameters; Lead; Mercury; Metabolism; Polymorphisms

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; LEAD; MERCURY; MULTIDRUG RESISTANCE PROTEIN 1; PORPHOBILINOGEN SYNTHASE; VITAMIN D RECEPTOR; ANTIOXIDANT; METHYLMERCURY DERIVATIVE; POLLUTANT;

ALLELE; ANTIOXIDANT; BLOOD; CONCENTRATION (COMPOSITION); DIET; GENETIC VARIATION; GENOTYPE; HEALTH RISK; LEAD; MERCURY (ELEMENT); METABOLISM; POLYMORPHISM; TOXICITY;

ADULT; ALLELE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAZIL; COMMUNITY; COMPARATIVE STUDY; CONTROLLED STUDY; DIET; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENETIC POLYMORPHISM; GENOTYPE; HEAVY METAL BLOOD LEVEL; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; ADOLESCENT; AGED; BLOOD; CROSS-SECTIONAL STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; METABOLISM; MIDDLE AGED; PHARMACOKINETICS; POLLUTANT; VERY ELDERLY; YOUNG ADULT;

BRAZIL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIOXIDANTS; BRAZIL; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; LEAD; MALE; METHYLMERCURY COMPOUNDS; MIDDLE AGED; POLYMORPHISM, GENETIC; YOUNG ADULT;

EID: 84923352122     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2015.02.017     Document Type: Article

References (57)

1. Abdel-Rahman S.Z., el-Zein R.A., Anwar W.A., Au W.W. A multiplex PCR procedure for polymorphic analysis of GSTM1 and GSTT1 genes in population studies. Cancer Lett. 1996, 107:229-233.
2. Aebi H. Catalase in vitro,. Methods Enzymol. 1984, 105:121-126.
3. ATSDR Agency for Toxic Substances and Disease Registry. Interaction profile for: Chlorpyrifos, mead, mercury, and methylmercury 2006, Department of Health and Human Services, Public Health Service, U.S.
4. ATSDR Agency for Toxic Substances and Disease Registry. Case Studies in Environmental Medicine (CSEM). Lead Toxicity. Course: WB 1105 2010, Department of Health and Human Services, Public Health Service, U.S.
5. Barbosa F., Fillion M., Lemire M., Passos C.J., Rodrigues J.L., Philibert A., Guimarães J.R., Mergler D. Elevated blood lead levels in a riverside population in the Brazilian Amazon. Environ. Res. 2009, 109:594-599.
6. Barcelos G.R.M., Angeli J.P.F., Serpeloni J.M., Grotto D., Rocha B.A., Bastos J.K., Knasmüller S., Barbosa F. Quercetin protects human-derived liver cells against mercury-induced DNA-damage and alterations of the redox status. Mutat. Res. 2011, 726:109-115.
7. Barcelos G.R.M., Grotto D., Serpeloni J.M., Angeli J.P.F., Rocha B.A., de Oliveira Souza V.C., Vicentini J.T., Emanuelli T., Bastos J.K., Antunes L.M., Knasmüller S., Barbosa F. Protective properties of quercetin against DNA damage and oxidative stress induced by methylmercury in rats. Arch. Toxicol. 2011, 85:1151-1157.
8. Barcelos G.R.M., de Marco K.C., Grotto D., Valentini J., Garcia S.C., Braga G.U.L., Barbosa F. Evaluation of glutathione-S-transferase GSTM1 and GSTT1 polymorphisms and methylmercury metabolism in an exposed Amazonian population. J. Toxicol. Environ. Health A 2012, 75:960-970.
9. Carneiro M.F.H., Evangelista F.S., Barbosa F. Manioc flour consumption as a risk factor for lead poisoning in the Brazilian Amazon. J. Toxicol. Environ. Health A 2013, 76:206-216.
10. Carocci A., Rovito N., Sinicropi M.S., Genchi G. Mercury toxicity and neurodegenerative effects. Rev. Environ. Contam. Toxicol. 2014, 229:1-18.
11. Clarkson T.W., Magos L. The toxicology of mercury and its chemical compounds. Crit. Rev. Toxicol. 2006, 36:609-662.
12. Crespo-López M.E., Macêdo G.L., Pereira S.I., Arrifano G.P., Picanço-Diniz D.L., do Nascimento J.L., Herculano A.M. Mercury and human genotoxicity: critical considerations and possible molecular mechanisms. Pharmacol. Res. 2009, 60:212-220.
13. Custodio H.M., Broberg K., Wennberg M., Jansson J.H., Vessby B., Hallmans G., Stegmayr B., Skerfving S. Polymorphisms in glutathione-related genes affect methylmercury retention. Arch. Environ. Health 2004, 59:588-595.
14. Department of Health, State of New York, 2008. Lead Exposure in Adults-A guide for Health Care Providers. Doc.2584. 12 p.
15. Duydu Y., Süzen H.S., Aydin A., Cander O., Uysal H., Işimer A., Vural N. Correlation between lead exposure indicators and sister chromatid exchange (SCE) frequencies in lymphocytes from inorganic lead exposed workers. Arch. Environ. Contam. Toxicol. 2001, 41:241-246.
16. de Almeida Lopes A.C., Navas-Acien A., Zamoiski R., Silbergeld E.K., Carvalho M.F., Buzzo M.L., Urbano M.R., Martins A.C., Paoliello M.M. Risk factors for lead exposure in adult population in southern Brazil. J. Toxicol. Environ. Health A 2015, 78:92-108.
17. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
18. Engström K.S., Strömberg U., Lundh T., Johansson I., Vessby B., Hallmans G., Skerfving S., Broberg K. Genetic variation in glutathione-related genes and body burden of methylmercury. Environ. Health Perspect. 2008, 116:734-739.
19. Farant J.P., Wigfield D.C. Biomonitoring lead exposure with delta-aminolevulinate dehydratase (ALA-D) activity ratios,. Int. Arch. Occup. Environ. Health 1982, 51:15-24.
20. Farina M., Frizzo M.E., Soares F.A., Schwalm F.D., Dietrich M.O., Zeni G., Rocha J.B., Souza D.O. Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice. Toxicol. Lett. 2003, 144:351-357.
21. Farina M., Aschner M., Rocha J.B. Oxidative stress in MeHg-induced neurotoxicity. Toxicol. Appl. Pharmacol. 2011, 256:405-417.
22. Flora S.J.S., Mittal M., Mehta A. Heavy metal induced oxidative stress and its possible reversal by chelation therapy. Indian J. Med. Res. 2008, 128:501-523.
23. Flora G., Gupta D., Tiwari A. Toxicity of lead: a review with recent updates. Interdiscip. Toxicol. 2012, 5:47-58.
24. Grotto D., Santa Maria L.D., Boeira S., Valentini J., Charão M.F., Moro A.M., Nascimento P.C., Pomblum V.J., Garcia S.C. Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography-visible detection. Pharm. Biomed. Anal. 2007, 43:619-624.
25. Grotto D., Barcelos G.R.M., Valentini J., Antunes L.M.G., Angeli J.P.F., Garcia S.C., Barbosa F. Low levels of methylmercury induce DNA damage in rats: protective effects of selenium. Arch. Toxicol. 2009, 83:249-254.
26. Grotto D., Valentini J., Fillion M., Passos C.J., Garcia S.C., Mergler D., Barbosa F. Mercury exposure and oxidative stress in communities of the Brazilian Amazon. Sci. Total Environ. 2010, 408:806-811.
27. Gundacker C., Gencik M., Hengstschläger M. The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: mercury and lead. Mutat. Res. 2010, 705:130-140.
28. Hunaiti A., Soud M., Khalil A. Lead concentration and the level of glutathione, glutathione S-transferase, reductase and peroxidase in the blood of some occupational workers from Irbid City, Jordan. Sci. Total Environ. 1995, 170:95-100.
29. Jenssen M.T., Brantsæter A.L., Haugen M., Meltzer H.M., Larssen T., Kvalem H.E., Birgisdottir B.E., Thomassen Y., Ellingsen D., Alexander J., Knutsen H.K. Dietary mercury exposure in a population with a wide range of fish consumption-self-capture of fish and regional differences are important determinants of mercury in blood. Sci. Total Environ. 2012, 439:220-229.
30. Kasperczyk S., Kasperczyk J., Ostałowska A., Zalejska-Fiolka J., Wielkoszyński T., Swietochowska E., Birkner E. The role of the antioxidant enzymes in erythrocytes in the development of arterial hypertension among humans exposed to lead. Biol Trace Elem. Res. 2009, 130:95-106.
31. Lee C.C., Chang J.W., Huang H.Y., Chen H.L. Factors influencing blood mercury levels of inhabitants living near fishing areas. Sci. Total Environ. 2012, 424:316-321.
32. Mo Z., Gao Y., Cao Y., Gao F., Jian L. An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review. Prostate 2009, 69:662-688.
33. Nardi E.P., Evangelista F.S., Tormen L., Pierre T.S., Curtius A.J., Barbosa F. The use of inductively coupled plasma mass spectrometry (ICP-MS) for the determination of toxic and essential elements in different types of food samples. Food Chem. 2009, 112:727-732.
34. NTP (National Toxicology Program),June 2012. NTP Monograph on Health Effects of Low-Level Lead.
35. Oskarsson A., Ohlin B., Ohlander E.M., Albanus L. Mercury levels in hair from people eating large quantities of Swedish freshwater fish. Food Addit. Contam. 1990, 7:555-562.
36. Oliveira A.A.S., Souza M.F., Lengert A.H., Oliveira M.T., Camargo R.B.O.G., Braga G.U.L., Cólus I.M.S., BarbosaJr.F., Barcelos G.R.M. Genetic polymorphisms in glutathione (GSH)-related genes affect the plasmatic Hg/whole blood Hg partitioning and the distribution between inorganic and methylmercury levels in plasma collected from a fish eating population. Biomed Res. Int. 2014, ID940952.
37. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med 1967, 70:158-169.
38. Palmer C.D., Lewis M.E., Geraghty C.M., Barbosa F., Parsons P.J. Determination of lead, cadmium and mercury in blood for assessment of environmental exposure: a comparison between inductively coupled plasma-mass spectrometry and atomic absorption spectrometry. Spectrochim. Acta B 2006, 61:980-990.
39. Passos C.J., Mergler D., Fillion M., Lemire M., Mertens F., Guimaraes J.R., Philibert A. Epidemiologic confirmation that fruit consumption influences mercury exposure in riparian communities in the Brazilian Amazon. Environ. Res. 2007, 105:183-193.
40. Passos C.J., Mergler D. Human mercury exposure and adverse health effects in the Amazon: a review. Cad. Saude Publica 2008, 24:S503-S520.
41. Passos C.J., Da Silva D.S., Lemire M., Fillion M., Guimaraes J.R., Lucotte M., Mergler D. Daily mercury intake in fish-eating populations in the Brazilian Amazon. J. Expo. Sci. Environ. Epidemiol. 2008, 18:76-87.
42. Patil A.J., Bhagwat V.R., Patil J.A., Dongre N.N., Ambekar J.G., Jailkhani R., Das K.K. Effect of lead (Pb) exposure on the activity of superoxide dismutase and catalase in battery manufacturing workers (BMW) of western Maharashtra (India) with reference to heme biosynthesis. Int. J. Environ. Res. Public Health 2006, 4:329-337.
43. Patrick L. Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern. Med. Rev. 2006, 11:114-127.
44. Pawlas N., Broberg K., Olewińska E., Prokopowicz A., Skerfving S., Pawlas K. Modification by the genes ALAD and VDR of lead-induced cognitive effects in children. Neurotoxicology 2012, 33:37-43.
45. Pinheiro M.C., Macchi B.M., Vieira J.L., Oikawa T., Amoras W.W., Guimarães G.A., Costa C.A., Crespo-López M.E., Herculano A.M., Silveira L.C., do Nascimento J.L. Mercury exposure and antioxidant defenses in women: a comparative study in the Amazon. Environ. Res. 2008, 107:53-59.
46. Sassa S. δ-Aminolevulinic acid dehydratase assay. Enzyme 1982, 28:133-145.
47. Schwartz B.S., Lee B.K., Lee G.S., Stewart W.F., Simon D., Kelsey K., Todd A.C. Associations of blood lead, dimercaptosuccinic acid chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes. Environ. Health Perspect. 2000, 108:949-954.
48. Sirivarasai J., Wananukul W., Kaojarern S., Chanprasertyothin S., Thongmung N., Ratanachaiwong W., Sura T., Sritara P. Association between Inflammatory marker, environmental lead exposure, and glutathione S-transferase gene. Biomed. Res. Int. 2013, 2013. (ID 474963).
49. Smith C.M., Wang X., Hu H., Kelsey K.T. A polymorphismin the delta-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead. Environ. Health Perspect. 1995, 103:248-253.
50. Süzen H.S., Duydu Y., Aydin A., Işimer A., Vural N. Influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in turkish storage battery manufacturing workers. Am. J. Ind. Med. 2003, 43:165-171.
51. Tan S.W., Meiller J.C., Mahaffey K.R. The endocrine effects of mercury in humans and wildlife. Crit. Rev. Toxicol. 2009, 39:228-269.
52. Ur-Rehman S. Effect of lead on lipid peroxidation, phospholipids composition, and methylation in erythrocyte of human. Biol. Trace Elem. Res. 2013, 154:433-439.
53. Usuki F., Yasutake A., Matsumoto M., Higuchi I. Chronic low-dose methylmercury administration decreases mitochondrial enzyme activities and induces myopathic changes in rats. J. Health Sci. 2001, 47:162-167.
54. Vahter M., Akesson A., Lidén C., Ceccatelli S., Berglund M. Gender differences in the disposition and toxicity of metals. Environ. Res. 2007, 104:85-95.
55. Vahter M., Gochfeld M., Casati B., Thiruchelvam M., Falk-Filippson A., Kavlock R., Marafante E., Cory-Slechta D. Implications of gender differences for human health risk assessment and toxicology. Environ. Res. 2007, 104:70-84.
56. Wakisaka I., Yanagihashi T., Sato M., Nakano A. Factors contributing to the difference of hair mercury concentrations between the sexes. Nihon Eiseigaku Zasshi 1990, 45:654-664.
57. Wright R.O., Silverman E.K., Schwartz J., Tsaih S.W., Senter J., Sparrow D., Weiss S.T., Aro A., Hu H. Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. Environ. Health Perspect. 2004, 112:746-750.