Differentiation syndrome in promyelocytic leukemia: Clinical presentation, pathogenesis and treatment

Mediterranean Journal of Hematology and Infectious Diseases

Volumn 3, Issue 1, 2011, Pages

  Rego, Eduardo Magalhães ^a   De Santis, Gil C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84923352027     PISSN: None     EISSN: 20353006     Source Type: Journal    
DOI: 10.4084/MJHID.2011.048     Document Type: Article

References (40)

1. Fenaux P, Chomienne C, Degos L. All-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia. Semin Hematol 2001 Jan;38(1):13-25. http://dx.doi.org/10.1016/S0037-1963(01)90002-2
2. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988 Aug;72(2):567-72. PMid:3165295
3. Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 2008 Mar 1;111(5):2505-15. http://dx.doi.org/10.1182/blood-2007-07-102798 PMid:18299451
4. Zhu J, Chen Z, Lallemand-Breitenbach V, de The H. How acute promyelocytic leukaemia revived arsenic. Nat Rev Cancer2002 Sep;2(9):705-13. http://dx.doi.org/10.1038/nrc887 PMid:12209159
5. de The H, Chen Z. Acute promyelocytic leukaemia: novel insights into the mechanisms of cure. Nat Rev Cancer2010 Nov;10(11):775-83. http://dx.doi.org/10.1038/nrc2943 PMid:20966922
6. Grimwade D, Mistry AR, Solomon E, Guidez F. Acute promyelocytic leukemia: a paradigm for differentiation therapy. Cancer Treat Res 2010;145:219-35. http://dx.doi.org/10.1007/978-0-387-69259-3_13 PMid:20306254
7. Frankel SR, Eardley A, Lauwers G, Weiss M, Warrell RP, Jr. The "retinoic acid syndrome" in acute promyelocytic leukemia. Ann Intern Med 1992 Aug 15;117(4):292-6. PMid:1637024
8. Tallman MS, Andersen JW, Schiffer CA, Appelbaum FR, Feusner JH, Ogden A, et al. Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome. Blood 2000 Jan 1;95(1):90-5. PMid:10607690
9. Larson RS, Tallman MS. Retinoic acid syndrome: manifestations, pathogenesis, and treatment. Best Pract Res Clin Haematol 2003 Sep;16(3):453-61. http://dx.doi.org/10.1016/S1521-6926(03)00043-4
10. Mandelli F, Diverio D, Avvisati G, Luciano A, Barbui T, Bernasconi C, et al. Molecular remission in PML/RAR alphapositive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy. Gruppo Italiano- Malattie Ematologiche Maligne dell'Adulto and Associazione Italiana di Ematologia ed Oncologia Pediatrica Cooperative Groups. Blood 1997 Aug 1;90(3):1014-21. PMid:9242531
11. Soignet SL, Frankel SR, Douer D, Tallman MS, Kantarjian H, Calleja E, et al. United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J Clin Oncol 2001 Sep 15;19(18):3852-60. PMid:11559723
12. Ravandi F, Estey E, Jones D, Faderl S, O'Brien S, Fiorentino J, et al. Effective treatment of acute promyelocytic leukemia with alltrans- retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin. J Clin Oncol 2009 Feb 1;27(4):504-10. http://dx.doi.org/10.1200/JCO.2008.18.6130 PMid:19075265
13. Wang G, Li W, Cui J, Gao S, Yao C, Jiang Z, et al. An efficient therapeutic approach to patients with acute promyelocytic leukemia using a combination of arsenic trioxide with low-dose all-trans retinoic acid. Hematol Oncol 2004 Jun;22(2):63-71. http://dx.doi.org/10.1002/hon.728 PMid:15468344
14. De Botton S, Dombret H, Sanz M, Miguel JS, Caillot D, Zittoun R, et al. Incidence, clinical features, and outcome of all trans-retinoic acid syndrome in 413 cases of newly diagnosed acute promyelocytic leukemia. The European APL Group. Blood 1998 Oct 15;92(8):2712-8. PMid:9763554
15. Luesink M, Jansen JH. Advances in understanding the pulmonary infiltration in acute promyelocytic leukaemia. Br J Haematol 2010 Nov;151(3):209-20. http://dx.doi.org/10.1111/j.1365-2141.2010.08325.x PMid:20735400
16. De Santis GC, Madeira MI, de Oliveira LC, Falcao RP, Rego EM. Cardiac stunning as a manifestation of ATRA differentiation syndrome in acute promyelocytic leukemia. Med Oncol 2011 Jan 26.
17. Yu W, Burns CM. All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis. J Clin Rheumatol 2009 Oct;15(7):358-60. http://dx.doi.org/10.1097/RHU.0b013e31818866d8 PMid:20009973
18. Kollef MH, Schuster DP. The acute respiratory distress syndrome. N Engl J Med 1995 Jan 5;332(1):27-37. http://dx.doi.org/10.1056/NEJM199501053320106 PMid:7646623
19. Oliveira LC, Romano LG, Prado-Junior BP, Covas DT, Rego EM, De Santis GC. Outcome of acute myeloid leukemia patients with hyperleukocytosis in Brazil. Med Oncol 2010 Dec;27(4):1254-9. http://dx.doi.org/10.1007/s12032-009-9367-9 PMid:19937404
20. Spitzer TR. Engraftment syndrome following hematopoietic stem cell transplantation. Bone Marrow Transplant 2001 May;27(9):893-8. http://dx.doi.org/10.1038/sj.bmt.1703015 PMid:11436099
21. Zarbock A, Ley K. Neutrophil adhesion and activation under flow. Microcirculation 2009 Jan;16(1):31-42. http://dx.doi.org/10.1080/10739680802350104 PMid:19037827 PMCid:2851240
22. Moraes TJ, Chow CW, Downey GP. Proteases and lung injury. Crit Care Med 2003 Apr,31(4 Suppl):S189-94. http://dx.doi.org/10.1097/01.CCM.0000057842.90746.1E PMid:12682439
23. Kawabata K, Hagio T, Matsuoka S. The role of neutrophil elastase in acute lung injury. Eur J Pharmacol 2002 Sep 6;451(1):1-10. http://dx.doi.org/10.1016/S0014-2999(02)02182-9
24. Shibakura M, Niiya K, Niiya M, Asaumi N, Yoshida C, Nakata Y, et al. Induction of CXC and CC chemokines by all-trans retinoic acid in acute promyelocytic leukemia cells. Leuk Res 2005 Jul;29(7):755-9. http://dx.doi.org/10.1016/j.leukres.2005.01.005 PMid:15927671
25. Luesink M, Pennings JL, Wissink WM, Linssen PC, Muus P, Pfundt R, et al. Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Blood 2009 Dec 24;114(27):5512-21. http://dx.doi.org/10.1182/blood-2009-02-204834 PMid:19828696
26. Tsai WH, Hsu HC, Lin CC, Ho CK, Kou YR. Role of interleukin-8 and growth-regulated oncogene-alpha in the chemotactic migration of all-trans retinoic acid-treated promyelocytic leukemic cells toward alveolar epithelial cells. Crit Care Med 2007 Mar;35(3):879-85. http://dx.doi.org/10.1097/01.CCM.0000256844.38259.27 PMid:17235257
27. Tsai WH, Shih CH, Lin CC, Ho CK, Hsu FC, Hsu HC. Monocyte chemotactic protein-1 in the migration of differentiated leukaemic cells toward alveolar epithelial cells. Eur Respir J 2008 May;31(5):957-62. http://dx.doi.org/10.1183/09031936.00135707 PMid:18216048
28. Larson RS, Brown DC, Sklar LA. Retinoic acid induces aggregation of the acute promyelocytic leukemia cell line NB-4 by utilization of LFA-1 and ICAM-2. Blood 1997 Oct 1;90(7):2747-56. PMid:9326242
29. Ninomiya M, Kiyoi H, Ito M, Hirose Y, Naoe T. Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line. Leukemia 2004 Mar;18(3):442-8. http://dx.doi.org/10.1038/sj.leu.2403284 PMid:14749706
30. Cunha De Santis G, Tamarozzi MB, Sousa RB, Moreno SE, Secco D, Garcia AB, et al. Adhesion molecules and Differentiation Syndrome: phenotypic and functional analysis of the effect of ATRA, As2O3, phenylbutyrate, and G-CSF in acute promyelocytic leukemia. Haematologica 2007 Dec;92(12):1615-22. http://dx.doi.org/10.3324/haematol.10607 PMid:18055984
31. Vahdat L, Maslak P, Miller WH, Jr., Eardley A, Heller G, Scheinberg DA, et al. Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: impact of leukocytosis, low-dose chemotherapy, PMN/RAR-alpha isoform, and CD13 expression in patients treated with all-trans retinoic acid. Blood 1994 Dec 1;84(11):3843-9. PMid:7949141
32. Santos FL, Dore AI, Lima AS, Garcia AB, Zago MA, Rizzatti EG, et al. [Hematological features and expression profile of myeloid antigens of acute promyelocytic leukemia patients: analysis of prognostic factors for development of the retinoic acid syndrome]. Rev Assoc Med Bras 2004 Jul-Sep;50(3):286-92. http://dx.doi.org/10.1590/S0104-42302004000300036
33. Montesinos P, Bergua JM, Vellenga E, Rayon C, Parody R, de la Serna J, et al. Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors. Blood 2009 Jan 22;113(4):775-83. http://dx.doi.org/10.1182/blood-2008-07-168617 PMid:18945964
34. Tallman MS, Kim HT, Montesinos P, Appelbaum FR, de la Serna J, Bennett JM, et al. Does microgranular variant morphology of acute promyelocytic leukemia independently predict a less favorable outcome compared with classical M3 APL? A joint study of the North American Intergroup and the PETHEMA Group. Blood 2010 Dec 16;116(25):5650-9. http://dx.doi.org/10.1182/blood-2010-06-288613 PMid:20858857
35. de Botton S, Chevret S, Coiteux V, Dombret H, Sanz M, San Miguel J, et al. Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: results from APL 93 trial. Leukemia 2003 Feb;17(2):339-42. http://dx.doi.org/10.1038/sj.leu.2402807 PMid:12592333
36. Dore AI, Santana-Lemos BA, Coser VM, Santos FL, Dalmazzo LF, Lima AS, et al. The association of ICAM-1 Exon 6 (E469K) but not of ICAM-1 Exon 4 (G241R) and PECAM-1 Exon 3 (L125V) polymorphisms with the development of differentiation syndrome in acute promyelocytic leukemia. J Leukoc Biol 2007 Nov;82(5):1340-3. http://dx.doi.org/10.1189/jlb.0207095 PMid:17704297
37. Jeddi R, Ghedira H, Mnif S, Gouider E, Fenaux P, Meddeb B. High body mass index is an independent predictor of differentiation syndrome in patients with acute promyelocytic leukemia. Leuk Res Apr,34(4):545-7.
38. Kawasaki K, Akaike H, Miyauchi A, Ouchi K. Sivelestat relieves respiratory distress refractory to dexamethasone in all-trans retinoic acid syndrome: a report of two cases. Eur J Haematol 2006 Nov;77(5):448-52. http://dx.doi.org/10.1111/j.0902-4441.2006.t01-1-EJH2852.x PMid:16930140 PMCid:1618807
39. Fenaux P, Chastang C, Chevret S, Sanz M, Dombret H, Archimbaud E, et al. A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed acute promyelocytic leukemia. The European APL Group. Blood 1999 Aug 15;94(4):1192-200. PMid:10438706
40. de la Serna J, Montesinos P, Vellenga E, Rayon C, Parody R, Leon A, et al. Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin. Blood 2008 Apr 1;111(7):3395-402. http://dx.doi.org/10.1182/blood-2007-07-100669 PMid:18195095