In vitro and in vivo effects of graphene oxide and reduced graphene oxide on glioblastoma

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 1585-1596

  Jaworski, Sławomir ^a   Sawosz, Ewa ^a   Kutwin, Marta ^a   Wierzbicki, Mateusz ^a   Hinzmann, Mateusz ^a   Grodzik, Marta ^a   Winnicka, Anna ^a   Lipińska, Ludwika ^b   Włodyga, Karolina ^a   Chwalibog, Andrè ^c  

^a WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

^b ukasiewicz Research Network Institute of Microelectronics and Photonics   (Poland)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Apoptosis; Glioma; Graphene oxide; Reduced graphene oxide; Toxicity

Indexed keywords

GRAPHENE OXIDE; GRAPHITE; NANOMATERIAL; OXIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BRDU ASSAY; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CHICKEN; CHORIOALLANTOIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; EMBRYO; GLIOBLASTOMA; GLIOMA CELL LINE; GRAPHENE OXIDE PLATELET; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; PROTEIN EXPRESSION; REDUCED GRAPHENE OXIDE PLATELET; THROMBOCYTE; TRANSMISSION ELECTRON MICROSCOPY; TUMOR VOLUME; U118 CELL LINE; U87 CELL LINE; XTT ASSAY; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; CHICK EMBRYO; DRUG EFFECTS;

ANIMALS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHICK EMBRYO; CHICKENS; GLIOBLASTOMA; GRAPHITE; HUMANS; NANOSTRUCTURES; OXIDES;

EID: 84923335527     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S77591     Document Type: Article

References (34)

1. Bernardi A, Frozza RL, Hoppe JB, et al. The antiproliferative effect of indomethacin-loaded lipid-core nanocapsules in glioma cells is mediated by cell cycle regulation, differentiation, and the inhibition of survival pathways. Int J Nanomedicine. 2013;8:711–728.
2. Shakur SF, Bit-Ivan E, Watkin WG, Merrell RT, Farhat HI. Multifocal and multicentric glioblastoma with leptomeningeal gliomatosis: a case report and review of the literature. Case Rep Med. 2013;2013:1–8.
3. Tabunoki H, Saito N, Suwanborirux K, Charupant K, Satoh J. Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids. Cancer Cell Int. 2011;12(1):14.
4. Grodzik M, Sawosz E, Wierzbicki M, et al. Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo. Int J Nanomedicine. 2011;6:3041–3048.
5. Wierzbicki M, Sawosz E, Grodzik M, Prasek M, Jaworski S, Chwalibog A. Comparison of anti-angiogenic properties of pristine carbon nanoparticles. Nanoscale Res Lett. 2013;8:195.
6. Geim AK, Novoselov KS. The rise of graphene. Nat Mater. 2007;6:183–191.
7. Uo M, Akasaka T, Watari F, Sato Y, Tohji K. Toxicity evaluations of various carbon nanomaterials. Dent Mater J. 2011;30:245–263.
8. Guo X, Mei N. Assessment of the toxic potential of graphene family nanomaterials. J Food Drug Anal. 2014;22:105–115.
9. Shan CS, Yang HF, Han DX, et al. Water-soluble graphene covalently functionalized by biocompatible poly-L-lysine. Langmuir. 2009;25:12030–12033
10. Sun XM, Liu Z, Welsher K, Goodwin A, Zaric S, Dai H. Nano-graphene oxide for cellular imaging and drug delivery. Nano Res. 2008;1:203–212.
11. Lei HZ, Mi LJ, Zhou XJ, et al. Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion. Nanoscale. 2011;3:3888–3892.
12. Zhang JL, Zhang F, Yang HJ, et al. Graphene oxide as a matrix for enzyme immobilization. Langmuir. 2010;26:6083–6085.
13. Dong HF, Gao WC, Yan F, et al. Fluorescence resonance energy transfer between quantum dots and graphene oxide for sensing biomolecules. Anal Chem. 2010;82:5511–5517.
14. Jaworski S, Sawosz E, Grodzik M, et al. In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells. Int J Nanomedicine. 2013;8:413–420.
15. Hinzmann M, Jaworski S, Kutwin M, et al. Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastoma multiforme cells. Int J Nanomedicine. 2014:9:2409–2417.
16. Jaworski S, Sawosz E, Grodzik M, et al. Comparison of tumour morphology and structure from U87 and U118 glioma cells cultured on chicken embryo chorioallantoic membrane. Bull Vet Inst Pulawy. 2013;57:593–598.
17. Ribatti D, Vacca A, Roncali L, Dammacco F. The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesis. Curr Pharm Biotechnol. 2000;1:73–82.
18. Yang Y, Rigdon W, Huang X, Li X. Enhancing graphene reinforcing. Sci Rep. 2013;3:1–7.
19. Shih CJ, Lin S, Sharma R, Strano MS, Blankschtein D. Understanding the pH-dependent behavior of graphene oxide aqueous solutions: a comparative experimental and molecular dynamics simulation study. Langmuir. 2012;28:235–241.
20. Bitounis D, Ali-Boucetta H, Hong BH, Min DH, Kostarelos K. Prospects and challenges of graphene in biomedical applications. Adv Mater. 2013;25:2258–2268.
21. Chang Y, Yang ST, Liu JH, et al. In vitro toxicity evaluation of graphene oxide on A549 cells. Toxicol Lett. 2011;200:201–210.
22. Chwalibog A, Sawosz E, Hotowy A, et al. Visualization of interaction between inorganic nanoparticles and bacteria or fungi. Int J Nanomedicine. 2010;5:1085–1094.
23. Liao KH, Lin YS, Macosko CW, Haynes CL. Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts. ACS Appl Mater Interfaces. 2011;3:2607–2615.
24. Yang W, Ratinack KR, Ringer SP, Thordarson P, Gooding JJ, Braet F. Carbon nanomaterials in biosensors: should you use nanotubes or graphene? Angew Chem Int Ed Engl. 2010;49: 2114–2138.
25. Liu JH, Anilkumar P, Cao L. Cytotoxity evaluations of fluorescent carbon nanoparticles. Nano Life. 2010;1:153–161.
26. Liu Z, Robinson JT, Sun X, Dai H. PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc. 2008;130:10876–10877.
27. Akhavan O, Ghaderi E, Akhavan A. Size-dependent genotoxicity of graphene nanoplatelets in human stem cells. Biomaterials. 2012;33:8017–8025.
28. Lv M, Zhang Y, Liang L, et al. Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line. Nanoscale. 2012;4:3861–3866.
29. Li Y, Liu Y, Fu Y, et al. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta siGPaling pathways. Biomaterials. 2012;33:402–411.
30. Stockmann-Juvala H, Naarala J, Loikkanen J, Vähäkangas K, Savolainen K. Fumonisin B1-induced apoptosis in neuroblastoma, glioblastoma and hypothalamic cell lines. Toxicology. 2006;225:234–241.
31. Zhu M, Weiss RS. Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse hus1 in primary cultured cells. Mol Biol Cell. 2007;18:1044–1055.
32. Murugesan S, Mousa SA, O’Connor LJ, Lincoln DW, Linhardt RJ. Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis. FEBS Lett. 2007;581:1157–1160.
33. Xu Y, Bai H, Lu G, Li C, Shi G. Flexible graphene films via the filtration of water-soluble. J Am Chem Soc. 2008;130:5856–5857.
34. Cohen-Tanugi D, Grossman JC. Water desalination across nanoporous graphene. Nano Lett. 2012;12:3602–3608.