Developmental biology: Is there such a thing as a cartilage-specific knockout mouse?

Nature Reviews Rheumatology

Volumn 10, Issue 12, 2014, Pages 702-704

  Pest, Michael A ^a   Beier, Frank ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; CRE RECOMBINASE; TRANSCRIPTION FACTOR SOX9;

APOPTOSIS; AUTOPHAGY; BONE DEVELOPMENT; BONE MATURATION; CARTILAGE CELL; CELL DEATH; CELL DIFFERENTIATION; CELL DIVISION; CELL LINEAGE; CELL PROLIFERATION; COL10A1 GENE; DISEASE COURSE; DOWN REGULATION; GENE; GENE EXPRESSION; GENE LOCUS; HUMAN; OSSIFICATION; OSTEOARTHRITIS; OSTEOBLAST; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; SHORT SURVEY; ANIMAL; CYTOLOGY;

ANIMALS; BONE DEVELOPMENT; CELL DIFFERENTIATION; CHONDROCYTES; OSTEOBLASTS; OSTEOCYTES;

EID: 84923332707     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2014.168     Document Type: Short Survey

References (10)

1. Yang, L., Tsang, K. Y., Tang, H. C., Chan, D. & Cheah, K. S. Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. Proc. Natl Acad. Sci. USA 111, 12097-12102 (2014).
2. Staines, K. A., Pollard, A. S., McGonnell, I. M., Farquharson, C. & Pitsillides, A. A. Cartilage to bone transitions in health and disease. J. Endocrinol. 219, R1-R12 (2013).
3. Long, F. & Ornitz, D. M. Development of the endochondral skeleton. Cold Spring Harb. Perspect. Biol. 5, a008334 (2013).
4. Shapiro, I. M., Adams, C. S., Freeman, T. & Srinivas, V. Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth Defects Res. C Embryo Today 75, 330-339 (2005).
5. Roach, H. I., Erenpreisa, J. & Aigner, T. Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis. J. Cell Biol. 131, 483-494 (1995).
6. Dy, P. et al. Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev. Cell 22, 597-609 (2012).
7. Fang, H. & Beier, F. Mouse models of osteoarthritis: modelling risk factors and assessing outcomes. Nat. Rev. Rheumatol. 10, 413-421 (2014).
8. Fosang, A. J., Golub, S. B., East, C. J. & Rogerson, F. M. Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26RLacZ reporter mice. Osteoarthritis Cartilage 21, 401-404 (2013).
9. Pest, M. A., Russell, B. A., Zhang, Y. W., Jeong, J. W. & Beier, F. Loss of mitogen-inducible gene 6 results in disturbed cartilage and joint homeostasis. Arthritis Rheum. http://dx.doi.org/10.1002/art.38758 (2014).
10. Manolagas, S. C. & Kronenberg, H. M. Reproducibility of results in pre-clinical studies: a perspective from the bone field. J. Bone Miner. Res. http://dx.doi.org/10.1002/jbmr.2293 (2014).